Retrospective analysis of patients with chronic idiopathic thrombocytopenic purpura

Among splenectomized patients with a primary unresponsive to PRD or dose-dependency or any contraindication to PRD therapy, the procedure had failed in 13 cases and in 8 of them postoperative thrombocyte counts were

📌 3 Key Takeaways

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Objective & Hypothesis:Chronic idiopathic thrombocytopenic purpura (1TP). is a kind of autoimmune disease, characterized by reticuloendothelial destruction of autoantibody—coated thrombocytes.

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Key Findings & Data:In this study 84 chronic ITP cases who had admitted to Uludağ University Medical Faculty, Hematology Department between 1987—1999 were evaluated retrospectively by means of symptoms and signs at the time of diagnosis, response to both conventional therapies and tertiary therapies in refractory cases.

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Conclusion & Impact:Among splenectomized patients with a primary unresponsive to PRD or dose-dependency or any contraindication to PRD therapy, the procedure had failed in 13 cases and in 8 of them postoperative thrombocyte counts were

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Domain Parameters

Abstract

Chronic idiopathic thrombocytopenic purpura (1TP). is a kind of autoimmune disease, characterized by reticuloendothelial destruction of autoantibody—coated thrombocytes. It's most common in young women with insidious onset. A valid algorhythmfor refractory cases has not been established yet, though there is no difficulty in diagnosis and a high chance of response to conventional therapies. In this study 84 chronic ITP cases who had admitted to Uludağ University Medical Faculty, Hematology Department between 1987—1999 were evaluated retrospectively by means of symptoms and signs at the time of diagnosis, response to both conventional therapies and tertiary therapies in refractory cases. Our results have shown sustained remission with 1—2 mglkglday prednisone (PRD) treatment in 24% (n:19) of cases. Among splenectomized patients with a primary unresponsive to PRD or dose-dependency or any contraindication to PRD therapy, the procedure had failed in 13 cases and in 8 of them postoperative thrombocyte counts were

Özet

Kronik idiopatik trombositopenik purpura (1TP), otoantikorlarla kaplı trombositlerin retiküloendoteliyal sistemde yıkılmasıyla karakterize otoimmün bir hastalıktır. Genç kadınlarda daha sık olup sinsi başlangıçlıdtr. Tanısında zorluk çekilmeyen ve konvansiyonel tedavilere büyük oranda yanıt alman bu hastalıkta refrakter olgular için henüz geçerli bir algoritma oluşturulamamıştır. Bu çalışmada, 1987—1999 yılları arasında fakültemiz Hematoloji Bilim Daiı'na başvuran toplam 84 kronik İTP'li olgunun, tanıdaki semptom ve fizik muayene bulguları, konvansiyonel tedavilere ve refrakter olguların tersiyer tedavilere cevapları retrospektif olarak değerlendirildi. Çalışmamızda, olgu¬ların %24'ünde (n:19) 1-2 mglkglgün dozunda prednizon (PRD) tedavisi ile kalıcı remisyon sağlandığını belirledik. PRD tedavisine primer cevapsız, doza bağımlı ya da PRD kullanımının sakıncalı olduğu 41 hastada uygulanan splenek-tominin 13 olguda başarısız olduğunu ve bu olguların 8'inde postop ilk 3 günde trombosit sayısının

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Cite This Article

OZAN, Ü., ÖZEN, Y., ÖZKALEMKAŞ, F., ALİ, R., TUNALI, A., ÖZÇELİK, T., ÖZKOCAMAN, V. (2022). Retrospective analysis of patients with chronic idiopathic thrombocytopenic purpura. Bursa Devlet Hastanesi Bülteni, Cilt: 19 - Sayı: 2, 71–74. https://ajindex.com/articles/469430

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