SavedAdd your journal

Journals / Bozok Tıp Dergisi / 2018 / Cilt: 8 - Sayı: 3

Role of Insulin Receptor Substrate 1 (IRS1) Protein in Insulin Resistance

İNSÜLİN DİRENCİNDE İNSÜLİN RESEPTÖR SUBSTRAT 1 (IRS1) PROTEİNİNİN ROLÜ

Gökhan GÖRGİŞEN
Pages
114–121
Publication Date
2022-10-11
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In this review, we aim to play pioneering role that clarifies the molecular mechanism of insulin resistance by focusing on the recent studies about the normal and pathologic regulations of IRS1 signaling.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Insulin resistance is defined as the reduced ability of insulin target tissues such as skeletal muscle, adipose and liver to respond properly to insulin actions.
📊
Key Findings & Data:Insulin resistance is a precursor of Type 2 diabetes and other pathological conditions.
💡
Conclusion & Impact:In this review, we aim to play pioneering role that clarifies the molecular mechanism of insulin resistance by focusing on the recent studies about the normal and pathologic regulations of IRS1 signaling.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Insulin resistance is defined as the reduced ability of insulin target tissues such as skeletal muscle, adipose and liver to respond properly to insulin actions. Insulin resistance is a precursor of Type 2 diabetes and other pathological conditions. Therefore, determining the pathogenesis of insulin resistance is important. Although molecular mechanisms of insulin resistance is not well-known, most of the studies showed that dysregulation of Insulin Receptor Substrate (IRS) signaling is a common situation that contribute to developing insulin resistance. In this review, we aim to play pioneering role that clarifies the molecular mechanism of insulin resistance by focusing on the recent studies about the normal and pathologic regulations of IRS1 signaling.

Özet

İnsülin direnci, iskelet kası, yağ ve karaciğer gibi insülinin hedef dokularının hücresel düzeydeinsüline gereken yanıtı verememesi ya da az vermesi durumudur. İnsülin direncinin başta Tip 2 Diyabetolmak üzere birçok hastalığın öncülü olması nedeniyle patogenezinin aydınlatılması oldukçaönem taşımaktadır. İnsülin direncine neden olan moleküler mekanizmalar tam olarak bilinmemektedir.Ancak son yıllarda yapılan çalışmalar, insülin direnci gelişimindeki etkin mekanizmalarınbaşında insülin reseptör substrat (IRS) proteinleri üzerinden gerçekleşen hücre sinyali regülasyonundakibozukluğun olduğunu ortaya koymuştur. Biz bu derlememizde IRS1 proteininin, normalve patolojik durumdaki regülasyonu hakkındaki son gelişmeleri ortaya koyarak, insülin direncioluşum mekanizmalarını aydınlatmaya yönelik yeni çalışmalara öncül olabilmeyi amaçlamaktayız.

🔖

Cite This Article

GÖRGİŞEN, G. (2022). Role of Insulin Receptor Substrate 1 (IRS1) Protein in Insulin Resistance. Bozok Tıp Dergisi, Cilt: 8 - Sayı: 3, 114–121. https://ajindex.com/articles/468641

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (14)

  1. Alghamdi F, Guo M, Abdulkhalek S, Crawford N, Amith SR, and Szewczuk MR. A novel insulin receptor-signaling platform and its link to insulin resistance and type 2 diabetes. Cell Signal. 2014;26(6):1355-68
  2. Perseghin G, Petersen K, and Shulman GI. Cellular mechanism of insulin resistance: potential links with inflammation. Int J Obes Relat Metab Disord. 2003;27 Suppl 3:S6-11
  3. Tanti JF and Jager J. Cellular mechanisms of insulin resistance: role of stress-regulated serine kinases and insulin receptor substrates (IRS) serine phosphorylation. Curr Opin Pharmacol. 2009;9(6):753-62
  4. Hancer NJ, Qiu W, Cherella C, Li Y, Copps KD, and White MF. Insulin and metabolic stress stimulate multisite serine/threonine phosphorylation of insulin receptor substrate 1 and inhibit tyrosine phosphorylation. J Biol Chem. 2014;289(18):12467-84
  5. Wilcox G. Insulin and insulin resistance. Clin Biochem Rev. 2005;26(2):19-39
  6. Draznin B. Molecular mechanisms of insulin resistance: serine phosphorylation of insulin receptor substrate-1 and increased expression of p85alpha: the two sides of a coin. Diabetes. 2006;55(8):2392-7
  7. Lee YH and White MF. Insulin receptor substrate proteins and diabetes. Arch Pharm Res. 2004;27(4):361-70
  8. Bevan P. Insulin signalling. J Cell Sci. 2001;114(Pt 8):1429-30
  9. Tamemoto H, Kadowaki T, Tobe K, Yagi T, Sakura H, Hayakawa T, et al. Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1. Nature. 1994;372(6502):182-6
  10. Guo S. Insulin signaling, resistance, and the metabolic syndrome: insights from mouse models into disease mechanisms. J Endocrinol. 2014;220(2):T1-T23
  11. Bryant NJ, Govers R, and James DE. Regulated transport of the glucose transporter GLUT4. Nat Rev Mol Cell Biol. 2002;3(4):267-77
  12. Araki E, Lipes MA, Patti ME, Bruning JC, Haag B, 3rd, Johnson RS, et al. Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene. Nature. 1994;372(6502):186-90
  13. Aspinwall CA, Qian WJ, Roper MG, Kulkarni RN, Kahn CR, and Kennedy RT. Roles of insulin receptor substrate-1, phosphatidylinositol 3-kinase, and release of intracellular Ca2+ stores in insulin-stimulated insulin secretion in beta -cells. J Biol Chem. 2000;275(29):22331-8
  14. Yamauchi T, Tobe K, Tamemoto H, Ueki K, Kaburagi Y, Yamamoto- Honda R, et al. Insulin signalling and insulin actions in the muscles and livers of insulin-resistant, insulin receptor substrate 1-deficient mice. Mol Cell Biol. 1996;