Serum Melatonin Levels in Patients with Sudden Sensorineural Hearing Loss

Objective & Hypothesis:Objective: This study aimed to investigate the serum melatoninlevels of patients with idiopathic sudden sensorineural hearing loss(ISSNHL).Methods: This study enrolled 22 patients with ISSNHL and 22asymptomatic healthy volunteers.

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Key Findings & Data:The subjects underwent puretone audiometry and serum melatonin levels were measured.Results: The patient group was composed of 12 women (meanage, 46.41±7.8) and 10 men (mean age, 48±6.46), and the controlgroup was composed of 12 women (mean age, 40.25±5.28) and10 men (mean age, 38.4±27.08).

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Conclusion & Impact:A statistically significant strong negativecorrelation was found between serum melatonin level and theseverity of hearing loss.

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Domain Parameters

Abstract

Objective: This study aimed to investigate the serum melatoninlevels of patients with idiopathic sudden sensorineural hearing loss(ISSNHL).Methods: This study enrolled 22 patients with ISSNHL and 22asymptomatic healthy volunteers. The subjects underwent puretone audiometry and serum melatonin levels were measured.Results: The patient group was composed of 12 women (meanage, 46.41±7.8) and 10 men (mean age, 48±6.46), and the controlgroup was composed of 12 women (mean age, 40.25±5.28) and10 men (mean age, 38.4±27.08). The serum melatonin levels weresignificantly lower in the patient group than in the control group(p≤0.001). A statistically significant strong negative correlation wasfound between serum melatonin level and severity of hearing loss(r=−0.644; p=0.001).Conclusion: Serum melatonin levels of patients with ISSNHLwere lower than controls. A statistically significant strong negativecorrelation was found between serum melatonin level and theseverity of hearing loss.

Özet

Amaç: Bu çalışmanın amacı, idiyopatik ani sensörinöral işitme kaybı (İASİK) olan hastaların serum melatonin düzeylerini ortaya koymaktır. Yöntemler: İASİK olan 22 hasta ve 22 asemptomatik sağlıklı gönüllü çalışmaya dahil edildi. Katılımcılara saf ses odyometrisi uygulandı ve katılımcıların serum melatonin seviyeleri ölçüldü. Bulgular: Hasta grubunda 12 kadın [ortalama (ort.) yaş: 46,41±7,8] ve 10 erkek (ort. yaş: 48±6,46) vardı. Kontrol grubunda 12 kadın (ort. yaş: 40,25±5,28) ve 10 erkek (ort. yaş: 38,4±27,08) vardı. Serum melatonin düzeylerinin hasta grubunda kontrol grubuna göre anlamlı derecede düşük olduğu saptandı (p≤0,001). Serum melatonin seviyesi ile işitme kaybının şiddeti arasında istatistiksel olarak anlamlı güçlü negatif bir korelasyon vardı (r=-0,644; p=0,001). Sonuç: İASİK olan hastaların serum melatonin düzeyleri kontrol grubundan daha düşüktü. Serum melatonin seviyesi ile işitme kaybının şiddeti arasında istatistiksel olarak anlamlı güçlü negatif bir korelasyon vardı.

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Cite This Article

BAKİ, A., YILDIZ, M., ÖZER, Ö. F., KÖKTAŞOĞLU, F. (2022). Serum Melatonin Levels in Patients with Sudden Sensorineural Hearing Loss. Bezmiâlem Science, Cilt: 8 - Sayı: 3, 269–274. https://ajindex.com/articles/464020

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