The protective effect of RVT might be associated with increased eNOS expres- sion and activity.
📌 3 Key Takeaways
🎯
Objective & Hypothesis:Results: LPS administration significantly inhibited the relaxation response induced by ACh, while the relax- ation to SNP was not significantly altered.
📊
Key Findings & Data:Phe- and KCl- induced contractile responses in the thoracic aorta sig- nificantly decreased in LPS-injected group. eNOS and p-eNOS expression decreased significantly in arteries obtained from LPS group rats.
💡
Conclusion & Impact:The protective effect of RVT might be associated with increased eNOS expres- sion and activity.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters
Abstract
Results: LPS administration significantly inhibited the relaxation response induced by ACh, while the relax- ation to SNP was not significantly altered. Phe- and KCl- induced contractile responses in the thoracic aorta sig- nificantly decreased in LPS-injected group. eNOS and p-eNOS expression decreased significantly in arteries obtained from LPS group rats. The impaired vasoreactiv- ity as well as decreased expressions of eNOS, p-eNOS, and SIRT1 in vessels from LPS-injected rats were im- proved by RVT treatment. Conclusion: The endothelium-dependent vasodilata- tion of the thoracic aorta was significantly inhibited by LPS administration, and RVT treatment may improve vascular endothelial function. The protective effect of RVT might be associated with increased eNOS expres- sion and activity.
🔖
Cite This Article
ÇELİK, Ç. Ö., TAŞATARGİL, A., UĞUREL, S. S., KUŞÇU, N., DALAKLIOĞLU, S. (2022). Resveratrol Prevented Lipopolysaccharide-Induced Endothelial Dysfunction in Rat Thoracic Aorta Through Increased eNOS Expression. Balkan Medical Journal, Cilt: 33 - Sayı: 2, 138–143. https://ajindex.com/articles/461278
Peters K, Unger RE, Brunner J, Kirkpatrick CJ. Molecular basis of endothelial dysfunction in sepsis. Cardiovasc Res 2003;60:49-57. [CrossRef] Poredos P. Endothelial dysfunction and cardiovascular disease. Pathophysiol Haemost Thromb 2002;32:274-7. [CrossRef] Aird WC. Endothelium as a therapeutic target in sepsis. Curr Drug Targets 2007;8:501-7. [CrossRef] Wu JM, Wang ZR, Hsieh, TC, Bruder JL, Zou JG, Huang YZ. Mechanism of cardioprotection by resveratrol, a phenolic antioxi- dantpresent in red wine (Review). Int J Mol Med 2001;8:3-17.
Mattagajasingh I, Kim CS, Naqvi A, Yamamori T, Hoffman TA, Jung SB, et al. SIRT1 promotes endothelium-dependent vascu- lar relaxation by activating endothelial nitric oxide synthase. Proc Natl Acad Sci U S A 2007;104:14855-60. [CrossRef] Wallerath T, Deckert G, Ternes T, Anderson H, Li H, Witte K, et al. Resveratrol, a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide syn- thase. Circulation 2002;106:1652-8. [CrossRef] Takahashi S, Nakashima Y. Repeated and long-term treatment with physiological concentrations of resveratrol promotes NO pro- duction in vascular endothelial cells. Br J Nutr 2012;107:774-80. [CrossRef] Lalu MM, Csont T, Schulz R. Matrix metalloproteinase activi- ties are altered in the heart and plasma during endotoxemia. Crit Care Med 2004;32:1332-7. [CrossRef] Khadour FH, Panas D, Ferdinandy P, Schulze C, Csont T, Lalu MM, et al. Enhanced NO and superoxide generation in dysfunc- tional hearts from endotoxemic rats. Am J Physiol Heart Circ Physiol 2002;283:H1108-15. [CrossRef] Lalu MM, Gao CQ, Schulz R. Matrix metalloproteinase in- hibitors attenuate endotoxemia induced cardiac dysfunction: a potential role for MMP-9. Mol Cell Biochem 2003;251:61-6. [CrossRef] Lalu MM, Cena J, Chowdhury R, Lam A, Schulz R. Matrix me- talloproteinases contribute to endotoxin and interleukin-1beta induced vascular dysfunction. Br J Pharmacol 2006;149:31-42. [CrossRef] Parker JL, Adams HR. Selective inhibition of endothelium-de- pendent vasodilator capacity by Escherichia coli endotoxemia. Circ Res 1993;72:539-55. [CrossRef] Umans JG, Wylam ME, Samsel RW, Edwards J, Schumacker PT. Effects of endotoxin in vivo on endothelial and smooth- muscle function in rabbit and rat aorta. Am Rev Respir Dis 1993;148:1638-45. [CrossRef] Salzman AL, Wang H, Wollert PS, Vandermeer TJ, Compton CC, Denenberg AG, et al. Endotoxin-induced ileal mucosal hy- perpermeability in pigs: role of tissu