Geographical Variations in Patients with Heart Failure and Preserved Ejection Fraction: A Sub-Group Analysis of the APOLLON Registry

Key Findings & Data:However, limited data are available regarding the geographical differences of patients with heart failure and preserved ejection fraction.Aims: The present subgroup analysis aims to investigate the geographical differences in clinical characteristics, management, and primary etiology of patients with heart failure and preserved ejection fraction in Turkey.Study Design: A cross-sectional study.Methods: A comPrehensive, ObservationaL registry of heart faiLure with mid-range and preserved ejection fractiON (APOLLON) is a multicenter and observational study conducted in seven regions of Turkey (NCT03026114).

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Conclusion & Impact:Comparatively, the Aegean and Mediterranean regions had older patients with heart failure and preserved ejection fraction (p

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Domain Parameters

Abstract

Background: Clinical characteristics of patients with heart failure may vary geographically. However, limited data are available regarding the geographical differences of patients with heart failure and preserved ejection fraction.Aims: The present subgroup analysis aims to investigate the geographical differences in clinical characteristics, management, and primary etiology of patients with heart failure and preserved ejection fraction in Turkey.Study Design: A cross-sectional study.Methods: A comPrehensive, ObservationaL registry of heart faiLure with mid-range and preserved ejection fractiON (APOLLON) is a multicenter and observational study conducted in seven regions of Turkey (NCT03026114). The present study is a post-hoc analysis of the APOLLON registry. In this substudy, we compared the clinical characteristics of 819 consecutive patients with heart failure and preserved ejection fraction (mean age, 67 years; 57.8% women) admitted to cardiology outpatient units in different geographical regions.Results: Based on the geographical distribution of the entire Turkish population, the highest number of patients enrolled were from Marmara (271 patients, 33.1%). All demographical characteristics, clinical and laboratory findings, comorbidities, primary etiology, and medications prescribed were significantly different between the regions. Furthermore, inter-regional gender differences were identified. Comparatively, the Aegean and Mediterranean regions had older patients with heart failure and preserved ejection fraction (p

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Cite This Article

ÇAKIR, M. O., ÇİL, C., BAŞARAN, Ö., ÖZLEK, B., ÖZLEK, E., BİTEKER, M., ÇELİK, O., MERT, K. U., DOĞAN, V., BEKAR, L., SANCAR, K. M., KAHRAMAN, S., ÇELİK, Y., RENCÜZOĞULLARI, İ., AGUŞ, H. Z., TEKİNALP, M., SEVİNÇ, S., ÖSKEN, A., M, G. Ö. (2022). Geographical Variations in Patients with Heart Failure and Preserved Ejection Fraction: A Sub-Group Analysis of the APOLLON Registry. Balkan Medical Journal, Cilt: 36 - Sayı: 4, 235–244. https://ajindex.com/articles/460989

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References (11)

Steinberg BA, Zhao X, Heidenreich PA, Peterson ED, Bhatt DL, Cannon CP, et al. Trends in patients hospitalized with heart failure and preserved left ventricular ejection fraction: prevalence, therapies, and outcomes. Circulation 2012;126:65-75. Braunwald E. Heart failure. JACC Heart Fail 2013;1:1-20.
Owan TE, Redfield MM. Epidemiology of diastolic heart failure. Prog Cardiovasc Dis 2005;47:320-32.
Dunlay SM, Roger VL, Redfield MM. Epidemiology of heart failure with preserved ejection fraction. Nat Rev Cardiol 2017;14:591-602.
Tribouilloy C, Rusinaru D, Mahjoub H, Soulière V, Lévy F, Peltier M, et al. Prognosis of heart failure with preserved ejection fraction: a 5 year prospective population-based study. Eur Heart J 2008;29:339-47.
Owan TE, Hodge DO, Herges RM, Jacobsen SJ, Roger VL, Redfield MM. Trends in prevalence and outcome of heart failure with preserved ejection fraction. N Engl J Med 2006;355:251-9.
Redfield MM, Jacobsen SJ, Burnett JC Jr, Mahoney DW, Bailey KR, Rodeheffer RJ. Burden of systolic and diastolic ventricular dysfunction in the community: appreciating the scope of the heart failure epidemic. JAMA 2003;289:194-202.
Metra M, Mentz RJ, Hernandez AF, Heizer GM, Armstrong PW, Clausell N, et al. Geographic Differences in Patients in a Global Acute Heart Failure Clinical Trial (from the ASCEND-HF Trial). Am J Cardiol 2016;117:1771-8.
Ferreira JP, Girerd N, Rossignol P, Zannad F. Geographic differences in heart failure trials. Eur J Heart Fail 2015;17:893-905.
Breathett K, Leng I, Foraker RE, Abraham WT, Coker L, Whitfield KE, et al. Risk Factor Burden, Heart Failure, and Survival in Women of Different Ethnic Groups: Insights From the Women's Health Initiative. Circ Heart Fail 2018;11:e004642. Bahrami H, Kronmal R, Bluemke DA, Olson J, Shea S, Liu K, et al. Differences in the incidence of congestive heart failure by ethnicity: the multi-ethnic study of atherosclerosis. Arch Intern Med 2008;168:2138-45.
Liu L, Yin X, Chen M, Jia H, Eisen HJ, Hofman A. Geographic Variation in Heart Failure Mortality and Its Association With Hypertension, Diabetes, and Behavioral-Related Risk Factors in 1,723 Counties of the United States. Front Public Health 2018;6:132. Jakab Z, Marmot M. Social determinants of health in Europe. Lancet 2012;379:103-5.
Değertekin M, Erol C, Ergene O, Tokgözoğlu L, Aksoy M, Erol MK, et al. [Heart failure prevalence and predictors in Turkey: HAPPY study]. Turk Kardiyol Dern Ars 2012;40:298-308. Birinci Coğrafya Kongresi (Kitabı). Ra