Journals / Bağcılar Tıp Bülteni / 2021 / Cilt: 6 - Sayı: 4

Evaluation of the Relationship Between the Severity of the Disease, the Neutrophil/ Lymphocyte Ratio and CRP in Children with Bronchiolitis

Bronşiolit Tanısıyla İzlenen Çocuklarda Hastalığın Şiddeti ile Nötrofil/ Lenfosit Oranı ve CRP Arasındaki İlişkinin Değerlendirilmesi

Pages
438–443
Publication Date
2022-10-12
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Keywords: Bronchiolitis, CRP, disease severity, neutrophil lymphocyte ratio

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: In this study, we aimed to evaluate the relationship among neutrophil-lymphocyte ratio (NLR), C-reactive protein (CRP) and disease severity in 0-2-year-old children diagnosed and hospitalized with bronchiolitis.
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Key Findings & Data:Method: This retrospective cross-sectional study includes 158 patients aged 0-2 years, who were hospitalized for bronchiolitis between 01.12.2018 and 04.01.2020 in University of Health Sciences Turkey, İstanbul Bağcılar Training and Research Hospital’s Pediatrics Clinic.
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Conclusion & Impact:Keywords: Bronchiolitis, CRP, disease severity, neutrophil lymphocyte ratio
🔬Design:Research Article
📍Scope:2018 Verileri
⚙️Variables:Domain Parameters

Abstract

Objective: In this study, we aimed to evaluate the relationship among neutrophil-lymphocyte ratio (NLR), C-reactive protein (CRP) and disease severity in 0-2-year-old children diagnosed and hospitalized with bronchiolitis. Method: This retrospective cross-sectional study includes 158 patients aged 0-2 years, who were hospitalized for bronchiolitis between 01.12.2018 and 04.01.2020 in University of Health Sciences Turkey, İstanbul Bağcılar Training and Research Hospital’s Pediatrics Clinic. Patients’ age, gender, laboratory results and disease severity scores were recorded. According to this, disease severity was categorized as mild, moderate and severe. Results: No statistically significant difference was observed among the scores of disease severity, mean age of the groups and gender distribution (p=0.061, p=0.392). However, a statistically significant difference was found between the disease severity score and the neutrophil/lymphocyte (N/L) ratios (p=0.007). The N/L ratio of the “mild” group was seen as statistically significantly lower than that of the “moderate” and “severe” groups (p=0.003, p=0.006). No statistically significant correlation was detected among the disease severity score, mean age of the moderate and severe groups (r=0.081 p=0.311). A statistically significant difference was witnessed between the disease severity score and CRP values (p=0.014). The CRP values of the group with mild disease were realized to be significantly lower than that of the group with moderate severity (p=0.04). Conclusion: An increase in the NLR along with CRP is associated with the clinical severity and is a beneficial parameter that can be used for evaluating the prognosis of 0-2-year-old hospitalized patients with bronchiolitis. Keywords: Bronchiolitis, CRP, disease severity, neutrophil lymphocyte ratio

Özet

Amaç: Çalışmamızda çocuk servisinde yatırılarak tedavi edilen bronşiolit tanısı alan 0-2 yaş arası çocuklarda nötrofil-lenfosit oranının (NLO) ve C-reaktif proteinin (CRP) hastalık şiddeti ile ilişkisinin değerlendirilmesi amaçlanmıştır. Yöntem: Bu retrospektif kesitsel çalışmaya Sağlık Bilimleri Üniversitesi, İstanbul Bağcılar Eğitim ve Araştırma Hastanesi Çocuk Servisi’nde 01.12.2018-04.01.2020 tarihleri arasında bronşiolit nedeniyle yatırılarak takip edilen 0-2 yaş arası 158 hasta dahil edildi. Hastaların yaşı, cinsiyeti, laboratuvar sonuçları ve hastalık ciddiyet skorları kaydedildi. Bu skorlamaya göre hastalık ciddiyeti hafif, orta ve ağır olarak değerlendirildi. Bulgular: Hastalık ciddiyet skoru ile grupların yaş ortalamaları arasında ve cinsiyet dağılımları arasında istatistiksel olarak anlamlı farklılık gözlenmemiştir (p=0,061, p=0,392). Hastalık ciddiyet skoru ile nötrofil/ lenfosit (N/L) oranı değerleri arasında istatistiksel olarak anlamlı farklılık gözlenmiştir (p=0,007). Hafif grubun N/L oranı orta ve ağır gruplardan istatistiksel olarak anlamlı derecede düşük bulunmuş (p=0,003, p=0,006), orta ve ağır grupların hastalık ciddiyet skoru ile yaş değerleri arasında istatistiksel olarak anlamlı korelasyon gözlenmemiştir (r=0,081 p=0,311). Hastalık ciddiyet skoru ile CRP değerleri arasında istatistiksel olarak anlamlı farklılık gözlenmiştir (p=0,014). Hastalık ciddiyeti hafif grubun CRP değerleri ciddiyeti orta olan gruptan anlamlı derecede düşük bulunmuştur (p=0,04). Sonuç: NLO’da artış CRP ile birlikte bronşiolit tanılı hastaların klinik ciddiyetiyle ilişkilidir ve çocuk servisinde yatan 0-2 yaş arası bronşiolit tanılı hastaların prognozunu değerlendirmek için kullanılabilecek faydalı bir parametredir. Anahtar kelimeler: Bronşiolit, CRP, hastalık ciddiyeti, nötrofil lenfosit oranı

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Cite This Article

ÖZEL, A., EROL, M., GAYRET, Ö. B., GÜNEŞ, Ö., BÜKE, Ö. (2022). Evaluation of the Relationship Between the Severity of the Disease, the Neutrophil/ Lymphocyte Ratio and CRP in Children with Bronchiolitis. Bağcılar Tıp Bülteni, Cilt: 6 - Sayı: 4, 438–443. https://ajindex.com/articles/458944

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