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Journals / Bağcılar Tıp Bülteni / 2021 / Cilt: 6 - Sayı: 2

Immunohistochemical Analysis of1.25-dihydroxyvitamin D3 Receptor Expression inEndometrial Cancer

Endometrium Kanserinde 1,25-dihidroksivitamin D3 Reseptör Ekspresyonunun İmmünohistokimyasal Analizi

Nesibe KAHRAMAN ÇETİN
Özgür Deniz TURAN
Pages
142–147
Publication Date
2022-10-12
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The intensity of expression, extent of staining and overall scores were determined for the semi-quantitative evaluation of VDR expression.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: This study aimed to immunohistochemically investigate the expression of 1.25-dihydroxyvitamin-D3-receptors (VDR) in benign and malignant lesions of the endometrial tissue.Method: The cases were divided into two groups as benign (n=10) and endometrioid adenocarcinoma (n=17) according to their endometrial pathology results.
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Key Findings & Data:The expression of VDR was examined by immunohistochemical method in endometrial tissues of participants (n=27).
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Conclusion & Impact:The intensity of expression, extent of staining and overall scores were determined for the semi-quantitative evaluation of VDR expression.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: This study aimed to immunohistochemically investigate the expression of 1.25-dihydroxyvitamin-D3-receptors (VDR) in benign and malignant lesions of the endometrial tissue.Method: The cases were divided into two groups as benign (n=10) and endometrioid adenocarcinoma (n=17) according to their endometrial pathology results. The expression of VDR was examined by immunohistochemical method in endometrial tissues of participants (n=27). Then, VDR expression levels were compared between the groups. The intensity of expression, extent of staining and overall scores were determined for the semi-quantitative evaluation of VDR expression. Demographic data of the patients were also recorded.Results: There was no significant difference between the groups in terms of demographic data (p>0.05) except age (p

Özet

Amaç: Bu çalışma, endometrial dokunun benign ve malign lezyonlarında1,25-dihidroksi-vitamin-D3-reseptörlerinin (VDR) ekspresyonunuimmünohistokimyasal olarak araştırmak için tasarlandı. Yöntem: Olgular endometrial patoloji sonuçlarına göre benign (n=10)ve endometrioid adenokarsinom (n=17) olarak iki gruba ayrıldı.Olgulara (n=27) ait olan endometrial dokulardaki VDR ekspresyonuimmünohistokimyasal yöntemlerle incelendi ve gruplar arasında VDRekspresyon seviyeleri karşılaştırıldı. VDR ekspresyonunun yarı niceldeğerlendirilmesi için ekspresyon yoğunluğu, boyanma dansitesi vegenel skorlar belirlendi. Hastalara ait demografik veriler kaydedildi. Bulgular: Gruplar arasında, yaş dışındaki (p0,05). Malign grupta VDR ekspresyon düzeyi benigngruba göre anlamlı olarak daha yüksekti (p

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Cite This Article

ÇETİN, N. K., TURAN, Ö. D. (2022). Immunohistochemical Analysis of1.25-dihydroxyvitamin D3 Receptor Expression inEndometrial Cancer. Bağcılar Tıp Bülteni, Cilt: 6 - Sayı: 2, 142–147. https://ajindex.com/articles/458913

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