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Journals / Meandros Medical And Dental Journal / 2022 / Volume: 23 Issue: 4

Evaluation of Oral Administration of Pirfenidone in Preventing Epidural Fibrosis Formation in Rats

Zahir Kızılay(ADNAN MENDERES UNIVERSITY)
Nesibe Kahraman Çetin(ADNAN MENDERES UNIVERSITY)
Özge Çevik(ADNAN MENDERES UNIVERSITY)
Serdar Aktaş(ADNAN MENDERES UNIVERSITY)
Hakan Öztürk(ADNAN MENDERES UNIVERSITY)
Pages
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Publication Date
2022-12-30
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusions: Pirfenidone can be a potential agent for EF treatment.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: To investigate the oral administration of pirfenidone on eperidural fibrosis formation (EF).
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Key Findings & Data:Group 1 (control), group 2 (25 mg/kg pirfenidone), and group 3 (50 mg/kg).
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Conclusion & Impact:Conclusions: Pirfenidone can be a potential agent for EF treatment.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Laminectomy · fibroblast growth factor · transforming growth factor

Abstract

Objective: To investigate the oral administration of pirfenidone on eperidural fibrosis formation (EF). Materials and Methods: Twenty four rats were divided into three equal groups. Group 1 (control), group 2 (25 mg/kg pirfenidone), and group 3 (50 mg/kg). Thoracic laminectomies were performed in all rats. Pirfenidone was given orally once a day for 30 days. Vertebral column samples were removed surgically at the end of the procedure. EF grading, number of fibroblasts and arachnoidal involvoment were evaluated. TGF-β1 and basic fibroblast growth factor (bFGF) were analyzed using quantitative real-time polymerase chain reaction, and synthesized proteins were examined. Results: In group 3, EF formation was less than the other groups. The factors in the emergence of antifibrotic activity at 50 mg/kg doses were investigated, and it was revealed that pirfenidone reduced fibroblast proliferation, and showed this effect by reducing TGF-β1 and bFGF expression in fibrotic tissue. Conclusions: Pirfenidone can be a potential agent for EF treatment.

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Cite This Article

Kızılay, Z., Çetin, N. K., Çevik, Ö., Aktaş, S., Öztürk, H. (2022). Evaluation of Oral Administration of Pirfenidone in Preventing Epidural Fibrosis Formation in Rats. Meandros Medical And Dental Journal, Volume: 23 Issue: 4. https://doi.org/10.4274/meandros.galenos.2021.60234

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