AI Summary & Key Takeaways
AI InsightThus, we recommend th,af sertraiine should be the first choice in the treatment of PE.
📌 3 Key Takeaways
Abstract
The aim of this study is to compare the efficacy and safety of ciomipramine and sertraiine in patients with premature ejaculation. The study included total 33 patients, with true premature ejaculation (PE), age ranged from 23 to 45 years old (mean: 30.5 years). The patients were randomly divided into 3 groups; 12 patients as ciomipramine group, 11 patients as sertraiine group and 10 patients as placebo group. Each patient took 1 capsule daily for the first week, then 2 daily for trie remaining 7 weeks. The efficacy of each drug was assessed With intravaginal ejaculation latency time and sexual satisfaction rate of patient and partner, and side effects of drugs were recorded. Mean intravaginal ejaculation time increased from 1.45 minutes (0.5-2•minutes) to 5.5 + 2 minutes, 5 + 2 minutes and 2.5 + 1.5 minutes in ciomipramine,- sertraiine and placebo-groups respectively. Sexual satisfaction rates of patients and partners were parallel with that intravaginal ejaculation durations. Side effect ratios were 90 % in ciomipramine group and 60 % in sertraiine group. Although the incidence of side effects with ciomipramine was significantly higher compared to that of sertraiine (p0.5). As a result sertraiine is as effective as ciomipramine in treatment of PE with minimal side effects compared to those of ciomipramine. Thus, we recommend th,af sertraiine should be the first choice in the treatment of PE.
Özet
Bu çalışmanın amacı, prematür ejakülasyon (PE) tedavisinde clomipramin ve sertralinin etkinlik ve güvenilirliklerini karşılaştırmaktır. Çalışmaya gerçek PE tanısı konulan yaşları 23-45 yıl (ortalama: 30.5 yıl) arasında olan toplam 33 hasta dahil edildi. Oniki hastaya clomipramin, 11 hastaya sertralin ve 10 hastaya plasebo 8' hafta süre ile verildi. Her bir ilacın etkinliği, intravajinal ejakülasyon süresi, hastalar ve cinsel partnerlerinin seksüel tatmin düzeyleri ile değerlendirildi ve yan etki oranları kaydedildi. İntravajinal ejakülasyon süresi clomipramin, sertralin ve plasebo gruplarında sırasıyla, 1.45 dakikadan (0.5-2 dakika), 5.5 + 2 dakikaya, 5 dakika + 2 dakikaya ve 2.5 +1.5 dakikaya değiştiği tespit edildi. Hasta ve cinsel partnerlerinin tatmin düzeyleri bu sürelerle paralellik gösteriyordu. Clomipramin grubunda yan etki oranı % 90 ve sertralin grubunda % 60 idi. Etkinlik bakımından clomipramin ve sertralin arasında istatistiksel anlamlı fark saptanmazken (p>0.5), yan etki bakımından 2 grup arasında anlamlı fark vardı (p