Journals / ARTEMİS / 2004 / Cilt: 5 - Sayı: 3

Normal ve IUGR'li gebeliklerde maternal serum leptin düzeyleri ve umbilikal arter Doppler indeksleri arasındaki ilişki

Relation between maternal serum leptin levels and fetal umbilical artery Doppler values in normal and IUGR pregnancies

Journal
ARTEMİS
Pages
213–216
Publication Date
2022-10-11
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

However,maternal serum leptin levels' loss of their diurnal pattern in IUGR and the correlation between maternal leptin values and umbilical artery Doppler changes in these fetuses may be important as a marker that may be used in the diagnosis and follow-up of IUGR and may offer new perspectives on etiology.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: To investigate the relation between umbilical artery Doppler values and maternal serum leptin levels in pregnant women having normal fetus and with intrauterine growth restriction Materials and Methods: This study was carried out in Fırat University Obstetrics and Gynecology Department on 16 healthy pregnant women having intrauterine growth restriction (IUGR) and 15 healthy pregnant women having normal fetus in the third trimester of pregnancy.
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Key Findings & Data:Maternal serum leptin levels and umbilical artery pulsatility index (PI), resistance index (RI) systole/diastole rates (S/D) of all cases were determined twice, at 01.00-02.00 a.m. and 10.0-11.00 a.m.
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Conclusion & Impact:However,maternal serum leptin levels' loss of their diurnal pattern in IUGR and the correlation between maternal leptin values and umbilical artery Doppler changes in these fetuses may be important as a marker that may be used in the diagnosis and follow-up of IUGR and may offer new perspectives on etiology.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: To investigate the relation between umbilical artery Doppler values and maternal serum leptin levels in pregnant women having normal fetus and with intrauterine growth restriction Materials and Methods: This study was carried out in Fırat University Obstetrics and Gynecology Department on 16 healthy pregnant women having intrauterine growth restriction (IUGR) and 15 healthy pregnant women having normal fetus in the third trimester of pregnancy. Pregnant women with normal fetus were allocated to group I and those with fetus that had IUGR were allocated to group II. Maternal serum leptin levels and umbilical artery pulsatility index (PI), resistance index (RI) systole/diastole rates (S/D) of all cases were determined twice, at 01.00-02.00 a.m. and 10.0-11.00 a.m. Results: Mean maternal serum leptin levels were significant in group I diurnal change (p0.05). The highest values in gravida with groupl were obtained at 01.00-02.00 a.m. at night. The correlation between umbilical artery Doppler values and serum leptin values in pregnant women group II was significant, but in the group I was not. Conclusion: The clinical use of maternal leptin levels in IUGR has not been documented yet. However,maternal serum leptin levels' loss of their diurnal pattern in IUGR and the correlation between maternal leptin values and umbilical artery Doppler changes in these fetuses may be important as a marker that may be used in the diagnosis and follow-up of IUGR and may offer new perspectives on etiology.

Özet

Amaç: Normal ve intrauterin gelişme geriliği fetuslara sahip gebelerde umblikal atrer Doppler değerleri ile maternal leptin düzeyleri arasındaki ilişkinin araştırılması. Materyal ve Metot: Bu çalışma Fırat Üniversitesi Kadın Hastalıkları ve Doğum ABD'da 16 intrauterin gelişme geriliği (IUGR) ve 15 sağlıklı üçüncü trimester gebe kadın üzerinde yapıldı. Normal fetusa sahip gebeler Grup I, IUGR'li fetusa sahip gebeler Grup II olmak üzere iki gruba ayrıldı. Tüm olguların gece saat 01:00-02:00 ve gündüz 10:00-11:00 aralığında olmak üzere iki kez serum leptin düzeyleri, umblikal arter pulsatilite Indeks(PI), Rezistans Indeks(RI) ve sistol/diastol oranlan (S/D) oranları belirlendi. Sonuçlar: Ortalama maternal serum leptin düzeylerinin diurnal değişimi normal gebelerde anlamlı bulunurken ( p0.05). Normal fetusa sahip gebelerde maternal serum leptin düzeyleri gece saat 01:00-02:00 arasında en yüksek değerlerde bulundu. IUGR gebelerde umblikal arter Doppler değerleri ile leptin değerleri arasındaki korelasyon anlamlı iken normal fetusa sahip olgularda anlamlı bulunmadı. Tartışma: Maternal Leptin düzeyinin IUGR'nin klinik takibinde herhangi bir kullanımı henüz yoktur. Bununla birlikte, Maternal serum leptin düzeylerinin IUGR'de diurnal patternini kaybetmiş olması ve bu fetuslarda maternal leptin değerleri ile umblikal arter Doppler değişimleri arasındaki korelasyon gerek IUGR'nin tanı ve takibinde bir marker, gerekse etiyolojiye daha farklı görüş açıları getirmesi bakımından olabilir.

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Cite This Article

SAPMAZ, E., ATILGAN, R., ÇELİK, H., PARMAKSIZ, C., HALEFOĞLU, İ., ÖZCAN, Z. (2022). Normal ve IUGR'li gebeliklerde maternal serum leptin düzeyleri ve umbilikal arter Doppler indeksleri arasındaki ilişki. ARTEMİS, Cilt: 5 - Sayı: 3, 213–216. https://ajindex.com/articles/449504

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