Journals / Abant Tıp Dergisi / 2012 / Cilt: 1 - Sayı: 1

JAK 2 positive chronic myeloproliferative neoplasia polycythemia vera and chronic lymphocytic leukemia coexistence: a rare case

Kronik lenfositik lösemili olguda JAK 2 pozitif kronik myeloproliferatif neoplazi polisitemia vera birlikteliği: nadir bir olgu

Pages
30–31
Publication Date
2012-01-01
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

We report a case of polycythemia vera which developed just after chronic lymphocytic leukemia.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Chronic lymphocytic leukemia is a malignant haematologic disease characterized of accumulation of abnormal lymphocytes mainly in peripheral blood and bone marrow.
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Key Findings & Data:Polycythemia vera is a myeloproliferative disorder characterized of overt production of mainly erythrocytes but also all three lineage.
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Conclusion & Impact:We report a case of polycythemia vera which developed just after chronic lymphocytic leukemia.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Kronik lenfositer lösemi · Polisitemia vera · JAK 2

Abstract

Chronic lymphocytic leukemia is a malignant haematologic disease characterized of accumulation of abnormal lymphocytes mainly in peripheral blood and bone marrow. Polycythemia vera is a myeloproliferative disorder characterized of overt production of mainly erythrocytes but also all three lineage. Simultaneous presentation of chronic lymphocytic leukemia and myeloproliferative disorders is very rare in literature. We report a case of polycythemia vera which developed just after chronic lymphocytic leukemia.

Özet

Kronik lenfositer lösemi, anormal lenfositlerin kan ve kemik iliği başta olmak üzere vücutta aşırı miktarda birikmesiyle oluşan malign bir hematolojik hastalıktır. Polisitemia vera ön planda eritrosit olmak üzere her üç hematopoetik hücre dizisinin aşırı üretimi ile sonuçlanan myeloproliferatif bir hastalıktır. Kronik lenfositer lösemi ve myeloproliferatif hastalıkların birlikteliği literatürde çok nadir olarak bildirilmiştir. Biz de burada kronik lenfositer lösemi sonrası polisitemia vera gelişen bir olguyu bildiriyoruz.

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Cite This Article

BAYRAM, M., ÖZKOCAMAN, V., ÖZKALEMKAŞ, F., ALİ, R., IRMAK, G., AYDIN, T., AKSOY, S., TUNALI, A. (2012). JAK 2 positive chronic myeloproliferative neoplasia polycythemia vera and chronic lymphocytic leukemia coexistence: a rare case. Abant Tıp Dergisi, Cilt: 1 - Sayı: 1, 30–31. https://ajindex.com/articles/449308

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References (7)

  1. Kodali S, Chen C, Rathnasabapathy C, Wang JC. JAK2 mutation in a patient with CLL with coexistent myeloproliferative neo- plasm (MPN). Leuk Res. 2009;33:263-9.
  2. Taberner DA, Chang J, Otride BW. Co-existent chronic lym- phatic leukemia with polycthaemia vera. Postgraduate Medi- cal Journal. 1977;53:222-3.
  3. Marisavljevic D, Radosevic-Radojkovic N, Basara B, Gotic M, Rolovic Z. Chronic lymphocytic leukemia associated with pol- ycythemia vera. Srp Arh Celok Lek. 1994;122:353 Koza I, Babusikova O. Sequential development of chronic lymphocytic leukemia in a patient with polycythemia vera. Neoplasma. 1988;35:77-80.
  4. Hussein K, Brakensiek K, Ballmaier M, et al. B-CLL developing in a patient with PV is not affected by V617F mutation of the Janus kinase 2. Eur J Haematol. 2006;77:539-41.
  5. Henry L, Carillo S, Jourdan E, Arnaud A, Brun S, Lavabre- Bertrand T. Association of essential thrombocythemia and chronic lymphocytic leukemia: absance of the V617F JAK2 mutation in the lymphoid compartment. Am J Hematol. 2007;82:500-1.
  6. Vannuchi AM, Masala G, Antonioli E. Increased risk of lym- phoid neoplasms in patients with Philadelphia chromosome- negative myeloproliferative neoplasms. Cancer Epidemiol Bi- omarkers Prev. 2009;18:2068-73.
  7. Mağın H, Akdoğan MF, Uyanık Ç, Gücün M, Palit F, Duranay M. Polisitemia Vera tanısında Jak-2 gen mutasyonunun önemi: Olgu sunumu ve literatürün gözden geçirilmesi. Bakırköy Tıp Dergisi. 2010;6:35-8.