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Journals / Archives of Rheumatology / 2018 / Cilt: 33 - Sayı: 3

Association of MICA Alleles and Human Leukocyte Antigen B in Turkish Patients Diagnosed With Behçet's Disease

Necmettin AKDENİZ
Nilnur EYERCİ
Eda BALKAN
Sadullah KELEŞ
Pages
352–357
Publication Date
2022-10-11
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

The gene frequency of MICA*006 was significantly higher in the BD patients compared to controls (14.5% vs. 0.9%; odds ratio [OR]: 17.092 95% confidence interval [CI] [2.155~135.554]; p

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: This study aims to investigate whether or not MHC class I polypeptide-related sequence A (MICA) polymorphisms are associated with the susceptibility to Behçet’s disease (BD) in a Turkish population.
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Key Findings & Data:Patients and methods: The study included 38 Turkish BD patients (20 males, 18 females; mean age 34±10.9 years) and 51 ethnically matched healthy controls (30 males, 21 females; mean age 36±12.8 years).
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Conclusion & Impact:The gene frequency of MICA*006 was significantly higher in the BD patients compared to controls (14.5% vs. 0.9%; odds ratio [OR]: 17.092 95% confidence interval [CI] [2.155~135.554]; p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: This study aims to investigate whether or not MHC class I polypeptide-related sequence A (MICA) polymorphisms are associated with the susceptibility to Behçet’s disease (BD) in a Turkish population. Patients and methods: The study included 38 Turkish BD patients (20 males, 18 females; mean age 34±10.9 years) and 51 ethnically matched healthy controls (30 males, 21 females; mean age 36±12.8 years). MICA and human leukocyte antigen B (HLA-B) alleles were determined in all subjects by using the Luminex technology. LABType® sequence-specific oligonucleotide (SSO) MICA test (One Lambda) and SSO B locus tests (Gene-Probe) were used for the typing studies. Results: A total of 16 MICA alleles were found in BD patients as well as in control subjects. The gene frequency of MICA*006 was significantly higher in the BD patients compared to controls (14.5% vs. 0.9%; odds ratio [OR]: 17.092 95% confidence interval [CI] [2.155~135.554]; p

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Cite This Article

AKDENİZ, N., EYERCİ, N., BALKAN, E., KELEŞ, S. (2022). Association of MICA Alleles and Human Leukocyte Antigen B in Turkish Patients Diagnosed With Behçet's Disease. Archives of Rheumatology, Cilt: 33 - Sayı: 3, 352–357. https://ajindex.com/articles/448029

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