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Journals / Annals of Medical Research / 2019 / Cilt: 26 - Sayı: 9

The association of fibroblast growth factor 23 with atherosclerosis and arterial stiffness in peritoneal dialysis patients

Suleyman DOLU
Emre ASİLTÜRK
Yildiz KİLAR SOZER
Melahat COBAN
Bekir EROL
Hamit Yasar ELLİDAG
Ayça İNCİ
Pages
2060–2067
Publication Date
2022-10-12
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

There wasno relationship between FGF-23 and atherosclerosis and arterial stiffness in PD patients.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: Increased serum fibroblast growth factor-23 (FGF-23) levels are associated with adverse cardiovascular events in chronickidney disease patients.
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Key Findings & Data:The aim of our study was to investigate the association of FGF-23 with atherosclerosis and arterial stiffnessin patients with peritoneal dialysis (PD).Material and Methods: This cross-sectional study was performed in 55 (34 (61.8%) male/21 (38.2%) female) PD patients with amean age of 53.1±11.4 years.
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Conclusion & Impact:There wasno relationship between FGF-23 and atherosclerosis and arterial stiffness in PD patients.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: Increased serum fibroblast growth factor-23 (FGF-23) levels are associated with adverse cardiovascular events in chronickidney disease patients. The aim of our study was to investigate the association of FGF-23 with atherosclerosis and arterial stiffnessin patients with peritoneal dialysis (PD).Material and Methods: This cross-sectional study was performed in 55 (34 (61.8%) male/21 (38.2%) female) PD patients with amean age of 53.1±11.4 years. The presence of atherosclerosis was determined by carotid artery-intima media thickness (CA-IMT)and the presence of arterial stiffness was determined by brachial-ankle pulse wave velocity (baPWV). Residual renal function wasdetermined by residual glomerular filtration rate (rGFR), renal creatinine clearance (CCr), and residual urine output. FGF-23 andsoluble klotho (s-KL) levels were determined by enzyme-linked immunosorbent assay.Results: CA-IMT (p 2.16. In multiple regression analysis there was an inverse relationship between log10 FGF-23 and rGFR (p =0.032), residual diuresis (p = 0.048), renal CCr (p = 0.045). There was no relationship with log10 FGF-23 and CA-IMT, baPWV (p > 0.05).Conclusion: Increased atherosclerosis and arterial stiffness were detected in PD patients compared to healthy subjects. There wasno relationship between FGF-23 and atherosclerosis and arterial stiffness in PD patients.

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Cite This Article

DOLU, S., ASİLTÜRK, E., SOZER, Y. K., COBAN, M., EROL, B., ELLİDAG, H. Y., İNCİ, A. (2022). The association of fibroblast growth factor 23 with atherosclerosis and arterial stiffness in peritoneal dialysis patients. Annals of Medical Research, Cilt: 26 - Sayı: 9, 2060–2067. https://ajindex.com/articles/447172

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