SavedAdd your journal

Journals / Annals of Medical Research / 2019 / Cilt: 26 - Sayı: 8

Serum inflammation biomarkers are associated with stages of Parkinson’s disease

Tamer YAZAR
Hülya Olgun YAZAR
Pages
1488–1492
Publication Date
2022-10-12
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The control groupcomprised individuals in the same age interval as IPD patients, with normal neurological examinations, Mental State Examination(MMSE) score above 24 and Geriatric Depression Rating Scale (GDRS) score below 11 who abided by the exclusion criteria.Results: For males and females in the IPD group, serum MLR, NLR and CAR were found to be high (p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aim: The aim was to identify serum neutrophil/lymphocyte ratio (NLR), monocyte/lymphocyte ratio (MLR), platelet/lymphocyte ratio(PLR) and C - reactive protein (CRP)/albumin ratio (CAR) according to disease stage in patients with idiopathic Parkinson disease(IPD).Material and Methods: The study included 211 patients IPD diagnosis and 200 healthy individuals abiding by the exclusion criteria.Patients with Stage 4 and 5 IPD according to Modified Hoehn and Yahr (H&Y) staging were not included in the study.
📊
Key Findings & Data:Aim: The aim was to identify serum neutrophil/lymphocyte ratio (NLR), monocyte/lymphocyte ratio (MLR), platelet/lymphocyte ratio(PLR) and C - reactive protein (CRP)/albumin ratio (CAR) according to disease stage in patients with idiopathic Parkinson disease(IPD).Material and Methods: The study included 211 patients IPD diagnosis and 200 healthy individuals abiding by the exclusion criteria.Patients with Stage 4 and 5 IPD according to Modified Hoehn and Yahr (H&Y) staging were not included in the study.
💡
Conclusion & Impact:The control groupcomprised individuals in the same age interval as IPD patients, with normal neurological examinations, Mental State Examination(MMSE) score above 24 and Geriatric Depression Rating Scale (GDRS) score below 11 who abided by the exclusion criteria.Results: For males and females in the IPD group, serum MLR, NLR and CAR were found to be high (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: The aim was to identify serum neutrophil/lymphocyte ratio (NLR), monocyte/lymphocyte ratio (MLR), platelet/lymphocyte ratio(PLR) and C - reactive protein (CRP)/albumin ratio (CAR) according to disease stage in patients with idiopathic Parkinson disease(IPD).Material and Methods: The study included 211 patients IPD diagnosis and 200 healthy individuals abiding by the exclusion criteria.Patients with Stage 4 and 5 IPD according to Modified Hoehn and Yahr (H&Y) staging were not included in the study. The control groupcomprised individuals in the same age interval as IPD patients, with normal neurological examinations, Mental State Examination(MMSE) score above 24 and Geriatric Depression Rating Scale (GDRS) score below 11 who abided by the exclusion criteria.Results: For males and females in the IPD group, serum MLR, NLR and CAR were found to be high (p

🔖

Cite This Article

YAZAR, T., YAZAR, H. O. (2022). Serum inflammation biomarkers are associated with stages of Parkinson’s disease. Annals of Medical Research, Cilt: 26 - Sayı: 8, 1488–1492. https://ajindex.com/articles/446834

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (18)

  1. Kalia LV, Lang AE. Parkinson’s disease. Lancet 2015;386:896- 912
  2. Markó-Kucsera M, Vécsei L, Paulik E. Association of cardiovascular risk factors and Parkinson’s Disease- a casa control study in South East Hungary. Ideggyogy Sz 2018;71:57-62
  3. Lökk J. Caregiver strain in Parkinson’s disease and the impact of disease duration. Eur J Phys Rehabil Med 2008;44:39-4
  4. Yazar T, Yazar HO, Zayimoğlu E. et al. Incidence of sarcopenia and dynapenia according to stage in patients with idiopathic Parkinson’s disease. Neurol Sci 2018;39:1415-21
  5. Gökçe Çokal B, Yurtdas M, Keskin Guler S, et al. Serum glutathione peroxidase, xanthine oxidase, and superoxide dismutase activities and malondialdehyde levels in patients with Parkinson’s disease. Neurol Sci 2017;38:425-31
  6. Blesa J, Trigo-Damas I, Quiroga-Varela A, et al. Oxidative stress and Parkinson’s disease. Front Neuroanat 2015;9:91
  7. Kaur K, Gill JS, Bansal PK, et al. Neuroinflammation - A major cause for striatal dopaminergic degeneration in Parkinson’s disease. J Neurol Sci 2017;381:308-14
  8. Pankratz N, Foroud T. Genetics of Parkinson Disease. NeuroRx 2004;1:235-42
  9. Gallagher DA, Schapira AH. Etiopathogenesis and treatment of Parkinson’s disease. Curr Top Med Chem 2009;9:860-8
  10. Jankovic J. Parkinson’s disease: clinical features and diagnosis. J Neurol Neurosurg Psychiatry 2008;79:368-76
  11. Yazar T, Yazar HO. Prevalance of sarcopenia according to decade. Clin Nutr ESPEN 2019;137-41
  12. Olgun Yazar H, Yazar, T. Prevalence of sarcopenia in patients with geriatric depression diagnosis. Ir J Med Sci 2019;188:931-8
  13. Akıl E, Bulut A, Kaplan İ, et al. The increase of carcinoembryonic antigen (CEA), high-sensitivity C-reactive protein, and neutrophil/lymphocyte ratio in Parkinson’s disease. Neurol Sci 2015;36:423-8
  14. Mungan S, Eruyar E, Güzel I, et al. Prognostic factors in Guillain-Barre syndrome. Dicle Med J 2014;41:667-70
  15. Ozdemir HH. Analysis of the albumin level, neutrophillymphocyte ratio, and platelet-lymphocyte ratio in Guillain- Barré syndrome. Arq Neuropsiquiatr 2016;74:718-22
  16. Akıl E, Akıl MA, Varol S, et al. Echocardiographic epicardial fat thickness and neutrophil to lymphocyte ratio are novel inflammatory predictors of cerebral ischemic stroke. J Stroke Cerebrovasc Dis 2014;23:2328-34
  17. Park MG, Kim MK, Chae SH, et al. Lymphocyte-to-monocyte ratio on day 7 is associated with outcomes in acute ischemic stroke. Neurol Sci 2018;39:243-9
  18. Niranjan R. Recent advances