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Journals / Düşünen Adam - Psikiyatri ve Nörolojik Bilimler Dergisi / 2011 / Cilt: 24 - Sayı: 2

Motor unit number estimation in Idiopathic Parkinson’s disease

İdiyopatik Parkinson hastalığında motor ünite sayısı değişimi

Tamer YAZAR
Karagöz Nazan SAKALLI
MEHMET BARIŞ BASLO
DURSUN KIRBAŞ
Yavuz ALTUNKAYNAK
VİLDAN AYŞE YAYLA
Pages
101–105
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

However, since there are limited numbers of publications on this subject, to verify this conclusion, further studies using similar methods, with larger patient groups are needed.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Motor neuron degeneration in parkinsonism is known to develop in Western Pacific (Guam) parkinsonism-amyotrophic lateral sclerosis complex, multisystem atrophy (MSA), postensefalitic parkinsonism, Creutzfeld-Jacob disease and dementia with parkinsonism linked to chromosome 17.
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Key Findings & Data:Methods: In this study, we estimated the motor unit counts in 24 patients diagnosed as IPD and 26 healthy control subjects with similar age (50-70) and gender, using threshold method.
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Conclusion & Impact:However, since there are limited numbers of publications on this subject, to verify this conclusion, further studies using similar methods, with larger patient groups are needed.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Motor neuron degeneration in parkinsonism is known to develop in Western Pacific (Guam) parkinsonism-amyotrophic lateral sclerosis complex, multisystem atrophy (MSA), postensefalitic parkinsonism, Creutzfeld-Jacob disease and dementia with parkinsonism linked to chromosome 17. Existence of motor neuron degeneration in these disorders brings up the question whether motor neuron degeneration develops in Idiopathic Parkinson Disease (IPD). Our study aims to answer this question. Methods: In this study, we estimated the motor unit counts in 24 patients diagnosed as IPD and 26 healthy control subjects with similar age (50-70) and gender, using threshold method. Results: Our study revealed the motor unit counts, done using threshold method, in IPD patients in thenar muscles were not different from the control group subjects. Conclusion: This result implied that there was not asymptomatic motor neuron degeneration in IPD, and IPD did not share the same physiological mechanism with other parkinsonism related disorders associated with motor neuron degeneration. However, since there are limited numbers of publications on this subject, to verify this conclusion, further studies using similar methods, with larger patient groups are needed.

Özet

Amaç: Parkinsonizmde motor nöron dejenerasyonunun Batı Pasifik (Guam) parkinsonizmi- Amiyotrofik Lateral Skleroz kompleksinde, Multisistem atrofisinde (MSA), postensefalitik parkinsonizmde, Creutzfeldt-Jakob hastalığında ve kromozom 17 ile bağlantılı demans-parkinsonizminde oluştuğu bilinmektedir. Bu hastalıklardaki motor nöron dejenerasyonunun varlığı, İdiyopatik Parkinson Hastalığı (İPH)’nda da motor nöronlarda dejenerasyonun olup olmadığı sorusunu akla getirmekte olup, çalışmamız bu soruya yanıt verebilmeyi amaçlamaktadır. Yöntem: İPH tanısı almış 24 hasta ve benzer yaş (50-70 yaş) ve cinsiyette 26 kişilik kontrol grubunda, eşik değer yöntemi ile tahmini motor ünite sayısı hesaplanmıştır. Bulgular: Eşik değer yöntemi ile İPH hastalarının tenar kaslarında, normal kontrol grubuna göre motor ünite sayısında bir farklılık olmadığı görülmüştür. Sonuç: Çalışmamız, İPH’de asemptomatik bir motor nöron dejenerasyonu bulunmadığını ve İPH’nin, parkinsonizmle birlikte motor nöron dejenerasyonu görülen hastalıklarla aynı fizyopatolojik mekanizmayı paylaşmadığını ortaya koymuştur. Bununla birlikte, literatürde bu konuda yapılmış az sayıda çalışma mevcuttur ve benzer yöntemlerle geniş örneklemler üzerinde yeni çalışmalara ihtiyaç vardır.

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Cite This Article

YAZAR, T., SAKALLI, K. N., BASLO, M. B., KIRBAŞ, D., ALTUNKAYNAK, Y., YAYLA, V. A. (2011). Motor unit number estimation in Idiopathic Parkinson’s disease. Düşünen Adam - Psikiyatri ve Nörolojik Bilimler Dergisi, Cilt: 24 - Sayı: 2, 101–105. https://ajindex.com/articles/218573

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