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Journals / Annals of Medical Research / 2020 / Cilt: 27 - Sayı: 8

Prognostic significance of poorly differentiated cluster grading system in intestinal type gastric adenocarcinoma

Emine ŞAMDANCI
Nusret AKPOLAT
Semra GÜRÜNLÜOĞLU
Nurhan ŞAHİN
Hasan GÖKÇE
Ahmet Kadir ARSLAN
Pages
2022–2030
Publication Date
2022-10-12
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

PDC tumor grades were statistically related to; medianmetastatic lymph node counts, metastatic lymph node ratios, lymph node stages (pN) and the presence of perineural invasion.Conclusion: In stomach carcinoma; PDC grading system was found to be related to a significant part of the expected parametersand may have a prognostic value.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: Gastric carcinoma is the fourth most common carcinoma worldwide.
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Key Findings & Data:We have aimed to investigate this concept in gastric carcinoma.Material and Methods: Our study included 80 cases, consisting of 16 females and 64 males having gastric carcinoma with intestinalmorphology.
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Conclusion & Impact:PDC tumor grades were statistically related to; medianmetastatic lymph node counts, metastatic lymph node ratios, lymph node stages (pN) and the presence of perineural invasion.Conclusion: In stomach carcinoma; PDC grading system was found to be related to a significant part of the expected parametersand may have a prognostic value.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: Gastric carcinoma is the fourth most common carcinoma worldwide. The relationships established between the tumormorphology and the prognosis have not been very effective until recent times. Poorly Differentiated Clusters (PDCs); are structuresthose can be easily identified in H&E sections. A new grading system based on PDC count has been studied in colorectal carcinoma;and found to be associated with prognosis. We have aimed to investigate this concept in gastric carcinoma.Material and Methods: Our study included 80 cases, consisting of 16 females and 64 males having gastric carcinoma with intestinalmorphology. For each case; conventional grade, PDC grade and prognostic parameters to be applied in the study were determined,and statistically compared.Results: Significant discrepancy was found between the two grading systems. PDC tumor grades were statistically related to; medianmetastatic lymph node counts, metastatic lymph node ratios, lymph node stages (pN) and the presence of perineural invasion.Conclusion: In stomach carcinoma; PDC grading system was found to be related to a significant part of the expected parametersand may have a prognostic value.

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Cite This Article

ŞAMDANCI, E., AKPOLAT, N., GÜRÜNLÜOĞLU, S., ŞAHİN, N., GÖKÇE, H., ARSLAN, A. K. (2022). Prognostic significance of poorly differentiated cluster grading system in intestinal type gastric adenocarcinoma. Annals of Medical Research, Cilt: 27 - Sayı: 8, 2022–2030. https://ajindex.com/articles/446613

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