Journals / Annals of Medical Research / 2022 / Cilt: 29 - Sayı: 5

Does the use of cannabinoids affect the ocular surface?

Pages
418–421
Publication Date
2022-10-12
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

This study showed that tear production, tear film stability, and impression cytology of patients with cannabis addiction were not different from the control group.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aim: To examine tear functions and ocular surface variables in patients with cannabis addiction.
📊
Key Findings & Data:In this study, 51 male patients with cannabis addiction (group 1) and 51 healthy volunteers (group 2) with similar demographic characteristics were included.
💡
Conclusion & Impact:This study showed that tear production, tear film stability, and impression cytology of patients with cannabis addiction were not different from the control group.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: To examine tear functions and ocular surface variables in patients with cannabis addiction. Materials and Methods: This clinical trial was planned as a prospective case-control study. In this study, 51 male patients with cannabis addiction (group 1) and 51 healthy volunteers (group 2) with similar demographic characteristics were included. Visual acuity, spherical equivalent, biomicroscopic examination, Schirmer test, tear break-up time (TBUT), and impression cytology (Nelson scores) results were recorded, and the 2 groups were compared with each other. Results: The mean Schirmer values were 9.68 ± 6.8 mm and 8.39 ± 4.08 mm in group 1 and group 2 (p = 0.97), respectively, whereas the mean TBUT values were 9.96±3.9 and 9.29±4.01s. (p = 0.35) and the mean Nelson scores were 1.49±1 and 1.25±0.97 in group 1 and group 2, respectively (p = 0.26). Conclusion: In this study, the effects of cannabis addiction on the ocular surface were evaluated using Schirmer, TBUT, and impression cytology methods. In the statistical analysis, no significant difference was found compared to the control group. This study showed that tear production, tear film stability, and impression cytology of patients with cannabis addiction were not different from the control group.

🔖

Cite This Article

CUMURCU, T., MUTLU, K., CUMURCU, B. E., ŞAMDANCI, E. (2022). Does the use of cannabinoids affect the ocular surface?. Annals of Medical Research, Cilt: 29 - Sayı: 5, 418–421. https://ajindex.com/articles/445669

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (15)

  1. UNODC. World Drug Report 2019 Cannabis and Hallucinogens: United Nations Publications; 2019
  2. Security GDo. Turkey Drug Report. In: Crimes DoN, editor. Ankara: Ministry of Interior Turkey; 2019. p. 67-8
  3. Skosnik PD, Edwards CR, O’donnell BF, Steffen A, Steinmetz JE, Hetrick WP. Cannabis use disrupts eyeblink conditioning: evidence for cannabinoid modulation of cerebellar-dependent learning. Neuropsychopharmacology. 2008;33(6):1432-40
  4. Safo PK, Regehr WG. Endocannabinoids control the induction of cerebellar LTD. Neuron. 2005;48(4):647-59
  5. Cumurcu T, Gunduz A, Cumurcu BE, Gül IG, Akpolat N, Karlidag R. The Changes in Tear Film Parameters and Impression Cytology in Heavily Drinking Men. Cornea. 2013;32(3):237-41
  6. Gunduz G, Gunduz A, Polat N, Cumurcu BE, Yakupogulları Y. The effect of chronic alcoholism on the conjunctival flora. Current eye research. 2016;41(6):734-9
  7. Nelson JD, Wright JC. Conjunctival goblet cell densities in ocular surface disease. Archives of ophthalmology. 1984;102(7):1049- 51
  8. Nelson JD, Havener VR, Cameron JD. Cellulose acetate impressions of the ocular surface: dry eye states. Archives of Ophthalmology. 1983;101(12):1869-72
  9. Altinors DD, Akça S, Akova YA, Bilezikçi B, Goto E, Dogru M, et al. Smoking associated with damage to the lipid layer of the ocular surface. American journal of ophthalmology. 2006;141(6):1016-21. e1
  10. Matsumoto Y, Dogru M, Goto E, Sasaki Y, Inoue H, Saito I, et al. Alterations of the tear film and ocular surface health in chronic smokers. Eye. 2008;22(7):961-8. 11. da Silva CMLR, de Sousa RARC, Baptista AMG. Assessment of tear amount in subjects under the effect of (inhaled) cocaine. Journal of psychoactive drugs. 2013;45(2):195-8
  11. Osei KA, Ovenseri-Ogbomo G, Kyei S, Ntodie M. The effect of caffeine on tear secretion. Optometry and Vision Science. 2014;91(2):171-7
  12. Yokoi N, Takehisa Y, Kinoshita S. Correlation of tear lipid layer interference patterns with the diagnosis and severity of dry eye. American journal of ophthalmology. 1996;122(6):818-24
  13. Straiker AJ, Maguire G, Mackie K, Lindsey JJIo, science v. Localization of cannabinoid CB1 receptors in the human anterior eye and retina. 1999;40(10):2442-8
  14. Iribarne Ma, Torbidoni V, Julián K, Prestifilippo JP, Sinha D, Rettori V, et al. Cannabinoid receptors in conjunctival epithelium: identification and functional properties. 2008;49(10):4535- 44
  15. Assimakopoulou M, Pagoulatos D, Nterma P, Pharmakakis NJMmr. Imm