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Journals / Annals of Medical Research / 2020 / Cilt: 27 - Sayı: 7

The diagnostic value of adrenomedullin and its relation with severity in patients with systolic heart failure

Abdulbaki KUMBASAR
Nilgün YILDIRIM
Pages
1972–1976
Publication Date
2022-10-12
DOI
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⚡ TL;DR(Too Long; Didn't Read)

Elevated ADM levels in HF were found to demonstrate a positive correlation withNew York Heart Association (NYHA) functional classifiation (r = 0.94, p < 0.001) and pulmonary arterial systolic pressure (PASP) (r =0.44, p

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: Adrenomedullin (ADM) is a vasodilator, natriuretic and antiproliferative peptide that lowers blood pressure and inhibits cellmigration.
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Key Findings & Data:The expression of cardiac ADM is increased in heart failure (HF).
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Conclusion & Impact:Elevated ADM levels in HF were found to demonstrate a positive correlation withNew York Heart Association (NYHA) functional classifiation (r = 0.94, p < 0.001) and pulmonary arterial systolic pressure (PASP) (r =0.44, p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: Adrenomedullin (ADM) is a vasodilator, natriuretic and antiproliferative peptide that lowers blood pressure and inhibits cellmigration. The expression of cardiac ADM is increased in heart failure (HF). The objective of this study was to investigate andsimultaneously compare the levels of probrain natriuretic peptide (pro-BNP) and ADM as a potential marker in patients with HF.Material and Methods: In this study, plasma levels of probrain natriuretic peptide and ADM were investigated in 90 subjects withsystolic heart failure and 90 healthy controls. The results were compared with appropriate statistical methods.Results: ADM levels were increased in patients with systolic HF with mean levels of 87.7 (81.4–99.7) pg/mL in HF group and 70.8(65.2–78.7) pg/mL in healthy controls (p < 0.001). Elevated ADM levels in HF were found to demonstrate a positive correlation withNew York Heart Association (NYHA) functional classifiation (r = 0.94, p < 0.001) and pulmonary arterial systolic pressure (PASP) (r =0.44, p

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Cite This Article

KUMBASAR, A., YILDIRIM, N. (2022). The diagnostic value of adrenomedullin and its relation with severity in patients with systolic heart failure. Annals of Medical Research, Cilt: 27 - Sayı: 7, 1972–1976. https://ajindex.com/articles/446607

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