A receiver operating characteristic (ROC) curve was constructed to assess sensitivity and specificity as well as optimal cut points for each presepsin to diagnose acute appendicitis.Results: Serum levels of CRP, WBC, NLR and presepsin were higher in complicated group compared with uncomplicated (p
📌 3 Key Takeaways
🎯
Objective & Hypothesis:AbstractAim: There is a growing body of evidence suggesting that the concentration of presepsin in serum was found to be increased in patients with sepsis compared to healthy individuals, but the clinical significance of presepsin in the diagnosis of complicated acute appendicitis remains unclear.
📊
Key Findings & Data:The purpose of this study was investigation of the diagnostic value of presepsin in complicated acuteappendicitis.Material and Methods: This clinical prospective single-center study was conducted between May and August 2018, and comprised 120 patients with definitive diagnosis of acute appendicitis and 30 individuals as control group.
💡
Conclusion & Impact:A receiver operating characteristic (ROC) curve was constructed to assess sensitivity and specificity as well as optimal cut points for each presepsin to diagnose acute appendicitis.Results: Serum levels of CRP, WBC, NLR and presepsin were higher in complicated group compared with uncomplicated (p
🔬Design:Research Article
📍Scope:2018 Verileri
⚙️Variables:Domain Parameters
Abstract
AbstractAim: There is a growing body of evidence suggesting that the concentration of presepsin in serum was found to be increased in patients with sepsis compared to healthy individuals, but the clinical significance of presepsin in the diagnosis of complicated acute appendicitis remains unclear. The purpose of this study was investigation of the diagnostic value of presepsin in complicated acuteappendicitis.Material and Methods: This clinical prospective single-center study was conducted between May and August 2018, and comprised 120 patients with definitive diagnosis of acute appendicitis and 30 individuals as control group. White blood cell count (WBC), C-reactive protein (CRP), neutrophil/lymphocyte ratio (NLR) and presepsin levels were measured from venous blood samples. A receiver operating characteristic (ROC) curve was constructed to assess sensitivity and specificity as well as optimal cut points for each presepsin to diagnose acute appendicitis.Results: Serum levels of CRP, WBC, NLR and presepsin were higher in complicated group compared with uncomplicated (p
🔖
Cite This Article
ISİKSACAN, N., BİNBOGA, S., ATA, P. K., BİNBOGA, E., KARABULUT, M., ALİS, H. (2022). Diagnostic value of presepsin in predicting a complicated acute appendicitis. Annals of Medical Research, Cilt: 27 - Sayı: 4, 1131–1137. https://ajindex.com/articles/446462
Rubér, M. Immunopathogenic aspects of resolving and progressing appendicitis (PhD dissertation). Linköping. Retrieved from http://urn.kb.se/ resolve?urn=urn:nbn:se:liu:diva-80375. (2012)
Drake FT, Mottey NE, Farrokhi ET, et al. Time to appendectomy and risk of perforation in acute appendicitis. JAMA Surg 2014;149:837-44
Andersson RE, Hugander AP, Ghazi SH, et al. Why does the clinical diagnosis fail in suspected appendicitis? Eur J Surg 2000;166:796-802
Bolandparvaz S, Vasei M, Owji AA, et al. Urinary 5-hydroxy indole acetic acid as a test for early diagnosis of acute appendicitis. Clin Biochem 2004;37:985-9
Bas S, Gauthier BR, Spenato U, et al. CD14 is an acutephase protein. J Immunol 2004;172:4470-9
Ozer OF, Guler EM, Kocyigit A, et al. Raftlin, presepsin levels and thiol-disulphide homeostasis in acute appendicitis: A pilot study. J Pak Med Assoc 2018;68:1660-5
Shirakawa K, Naitou K, Hirose J, et al. Presepsin (sCD14-ST): Development and evaluation of one-step ELISA with a new standard that is similar to the form of presepsin in septic patients. Clin Chem Lab Med 2011;49:937-9
Spanuth E, Ebelt H, Ivandic B, et al. Diagnostic and prognostic value of soluble CD14 subtype (sCD14- ST) in emergency patients with early sepsis using the new assay PATHFAST presepsin. 21st International Congress of Clinical Chemistry and Laboratory Medicine, IFCC-WorldLab e Euro Med Lab 2011:129-33
Al-Omran M, Mamdani MM, McLeod RS. Epidemiologic features of acute appendicitis in Ontario, Canada. Can J Surg 2003;46:263-8
DeLong ER, DeLong DM, Clarke-Pearson DL. Comparing areas under two or more correlated reciever operating characteristics curves: a nonparamentric approach. Biometrics 1988;44:837-45
Faul F, Erdfelder E, Buchner A, et al. Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses. Behav Res Methods 2009;41:1149-60
Peranteau WH, Smink DS. Appendix, Meckel’s, and Other Small Bowel Diverticula. In: Zinner MJ, Ashley SW. eds. Maingot’s Abdominal Operations. New York: McGraw-Hill 2013;643-4
Buyukbese Sarsu S, Sarac F. Diagnostic Value of White Blood Cell and C-Reactive Protein in Pediatric Appendicitis. Biomed Res Int 2016;2016:6508619
Mohammed AA, Daghman NA, Aboud SM, et al. The diagnostic value of C-reactive protein, white blood cell count and neutrophil percentage in childhood appendicitis. Saudi Med J 2004;25:1212-5
Guller U, Rosella L, McCall J, et al. Negative appe