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Journals / Dicle Tıp Dergisi / 2018 / Cilt: 45 Sayı: 4

Assessment of long term prognostic value of admission vitamin D level in patients with acute STEMI undergoing primary percutaneous coronary intervention

Muhammet Hulusi Satilmisoglu0000-0001-9429-4406
Mehmet Gul0000-0002-5721-8778
Huseyin Altug Cakmak0000-0002-5101-1928
Nilgun Isiksacan0000-0002-0230-6500
Selahattin Turen0000-0001-6752-1941
Ugur Kokturk0000-0003-0459-9295
Emre Yilmaz0000-0002-1656-3778
Muammer Karakayalı0000-0001-7385-120X
Aydin Rodi Tosu0000-0003-3545-0418
Pages
369–377
Publication Date
2018-12-13
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Vitamin-D deficiency is an independent predictor for long term cardiovascular mortality in acute STEMI undergoing PPCI.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Vitamin-D status is very important for optimal function of human body especially cardiovascular system.
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Key Findings & Data:The study patients were divided into 2 groups according to their vitamin-D levels as follows: High vitamin-D group (n=80) and Low vitamin-D group (n=77).
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Conclusion & Impact:Vitamin-D deficiency is an independent predictor for long term cardiovascular mortality in acute STEMI undergoing PPCI.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:Vitamin D · Mortality · SYNTAX score.

Özet

Objective: Vitamin-D status is very important for optimal function of human body especially cardiovascular system. The aim of this study was to investigate the long term prognostic value of admission vitamin D level in acute ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI). Methods: One hundred fifty seven consecutive patients, who were admitted to a training and research hospital with a diagnosis of STEMI and underwent PPCI, were recruited in this prospective study. The study patients were divided into 2 groups according to their vitamin-D levels as follows: High vitamin-D group (n=80) and Low vitamin-D group (n=77). The severity of coronary artery disease (CAD) was assessed with calculation of the SYNTAX score. Results: There were significant negative correlations between Vitamin-D level and SYNTAX score, serum glucose, and gender, but a positive correlation with hemoglobin level. Cardiovascular mortality was found to be significantly higher in the low vitamin-D group as compared to the high group (p<0.001). In multivariate analysis, low vitamin-D level was found as a significant independent predictor of long term cardiovascular mortality after adjusting for other risk factors. Conclusion: We demonstrated that low admission vitamin-D is related to severity of CAD. Vitamin-D deficiency is an independent predictor for long term cardiovascular mortality in acute STEMI undergoing PPCI.

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Cite This Article

Satilmisoglu, M. H., Gul, M., Cakmak, H. A., Isiksacan, N., Turen, S., Kokturk, U., Yilmaz, E., Karakayalı, M., Tosu, A. R. (2018). Assessment of long term prognostic value of admission vitamin D level in patients with acute STEMI undergoing primary percutaneous coronary intervention. Dicle Tıp Dergisi, Cilt: 45 Sayı: 4, 369–377. https://doi.org/10.5798/dicletip.497879

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References (23)

  1. Lee JH, O'Keefe JH, Bell D, et al. Vitamin D deficiency an important, common, and easily treatable cardiovascular risk factor?.J Am Coll Cardiol. 2008; 52: 1949-56.
  2. Li YC. Vitamin D regulation of the renin-angiotensin system. J Cell Biochem. 2003; 88: 327–31.
  3. Ortega A, Pérez de Prada MT, Mateos-Cáceres PJ, et al. Effect of parathyroidhormone- related protein on human platelet activation. Clinical Science. 2007; 113: 319–27.
  4. Pittas AG, Lau J, Hu FB, et al. The role of vitamin D and calcium in type 2 diabetes: a systematic review and meta-analysis. J Clin Endocrinol Metab. 2007; 92: 2017–29.
  5. Lee JH1, Gadi R, Spertus JA, el al. Prevalence of vitamin D deficiency in patients with acute myocardial infarction. Am J Cardiol. 2011; 107: 1636-8.
  6. Holick MF. Vitamin D deficiency. N Engl J Med. 2007; 357: 266-81. Review.
  7. Zittermann A, Kuhn J, Dreier J, et al. Vitamin D status and the risk of major adverse cardiac and cerebrovascular events in cardiac surgery. Eur Heart J. 2013; 34: 1358-64.
  8. Wang TJ1, Pencina MJ, Booth SL, et al. Vitamin D deficiency and risk of cardiovascular disease. Circulation. 2008; 117: 503-11.
  9. Khalili H, Talazaz AH, Salarifar M. Serum vitamin D concentration status and its correlation with early biomarkers of remodeling following acute myocardial infarction. Clinical Res Cardiology. 2012; 101: 321–7.
  10. Pilz S, März W, Wellnitz B, et al. Association of Vitamin D deficiency with heart failure and sudden cardiac death in a large cross sectional study of patient referred for coronary angiography. J Clin Endocrinol Metab. 2008; 93: 3927–35.
  11. De Metrio M, Milazzo V, Rubino M, et al. Vitamin D plasma levels and in-hospital and 1-year outcomes in acute coronary syndromes: a prospective study. Medicine (Baltimore). 2015; 94: e857.
  12. Correia LC1, Sodré F, Garcia G, et al. Relation of severe deficiency of vitamin D to cardiovascular mortality during acute coronary syndromes. Am J Cardiol. 2013; 111: 324-7.
  13. Naesgaard PA, León De La Fuente RA, Nilsen ST, et al. Serum 25 (OH) D is a 2-year predictor of all-cause mortality, cardiac death and sudden cardiac death in chest pain patients from Northern Argentina. PLoS One. 2012; 7: e43228.
  14. Ünal T,N Çayır A, Kaya A. Is low serum 25(OH) vitamin D a risk factor for childhood pneumonias?. Dicle Medical Journal. 2012; 39: 531-5.
  15. Demer LL, Hsu JJ, Tintut Y. Steroid Hormone Vitamin D: Impliations for Cardiovascular Disease. Circ Res. 2018; 22: 1576-85.
  16. Kilkkinen A, Knekt P, Aro A, et al. Vitamin D status and the risk of cardiovascular disease death. Am J Epidemiol. 2009; 170: 1032-9.
  17. Wang TJ1, Pencina MJ, Booth SL, et al. Vitamin D deficiency and risk of cardiovascular disease. Circulation. 2008; 117: 503-11.
  18. Ng LL, Sandhu JK, Squire IB, et al. Vitamin D and prognosis in acute myocardial infarction. Int J Cardiol. 2013; 168: 2341-6.
  19. Dobnig H, Pilz S, Scharnagl H, et al. Independent association of low serum 25- hydroxyvitamin d and 1,25-dihydroxyvitamin d levels with all-cause and cardiovascular mortality. Arch Intern Med. 2008; 168: 1340-9.
  20. Khalili H, Talasaz AH, Salarifar M. Serum vitamin D concentration status and its correlation with early biomarkers of remodeling following acute myocardial infarction. Clin Res Cardiol. 2012; 101: 321-7.
  21. Lavie CJ, Lee JH, Milani RV. Vitamin D and cardiovascular disease will it live up to its hype? J Am Coll Cardiol. 2011; 58: 1547-56.
  22. Ozturk G, Bulut E, Akyol S, et al. The effect of serum 25(OH) vitamin D on hemogram parameters. Dicle Medical Journal. 2014; 41: 332-6.
  23. Kinlay S, Ganz P. Relation between endothelial dysfunction and the acute coronary syndrome: implications for therapy. Am J Cardiol. 2000; 86: 10J-13J; discussion 13J-14J.Review.