SavedAdd your journal

Journals / Annals of Medical Research / 2021 / Cilt: 28 - Sayı: 1

The role of right precordial intrinsicoid deflection time in determining the conversion of Type 2 Brugada ECG pattern to Type 1 Brugada ECG pattern on 12-lead electrocardiogram with ajmaline test

İlyas ATAR
Casit Olgun ÇELİK
Volkan CAMKIRAN
Orçun ÇİFTÇİ
Bülent OZİN
Pages
144–148
Publication Date
2022-10-12
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Group 1 had a significantly greater IDT than Group 2 (28 (17.1-78.0) msec vs 21 (16.0-36.9) msec; p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aim: Brugada syndrome is a genetic disorder associated with fatal ventricular arrhythmias.
📊
Key Findings & Data:Type 1 (cove-type) ECG pattern is diagnostic for Brugada syndrome while Type 2 (saddle-type) ECG pattern requires ajmaline test to convert it to Type 1 ECG pattern to make the diagnosis.
💡
Conclusion & Impact:Group 1 had a significantly greater IDT than Group 2 (28 (17.1-78.0) msec vs 21 (16.0-36.9) msec; p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: Brugada syndrome is a genetic disorder associated with fatal ventricular arrhythmias. Type 1 (cove-type) ECG pattern is diagnostic for Brugada syndrome while Type 2 (saddle-type) ECG pattern requires ajmaline test to convert it to Type 1 ECG pattern to make the diagnosis. However, this test may cause ventricular arrhythmias and death. Intrinsicoid deflection time (IDT) is an ECG parameter reflecting intraventricular conduction delay, which is one of the pathophysiological mechanisms for Brugada syndrome. We examined IDT for conversion of type 2 Brugada pattern to type 1 Brugada pattern in ajmaline test.Materials and Methods: This retrospective study involved patients with Type 2 ECG pattern that was converted to Type 1 ECG pattern with ajmaline test (Group 1) and an age- and sex-matched control group with a normal ECG (Group 2). IDT was digitally measured in the lead V2, from the onset of the QRS complex to the peak of the R wave and compared between the study groups. A ROC curve was drawn to test the predictive ability of IDT for conversion to Type 1 ECG pattern. Results: There were 28 subjects (21 men, 7 women) in Group 1 and 28 subjects (21 men, 7 women) in Group 2. Group 1 had a significantly greater IDT than Group 2 (28 (17.1-78.0) msec vs 21 (16.0-36.9) msec; p

🔖

Cite This Article

ATAR, İ., ÇELİK, C. O., CAMKIRAN, V., ÇİFTÇİ, O., OZİN, B. (2022). The role of right precordial intrinsicoid deflection time in determining the conversion of Type 2 Brugada ECG pattern to Type 1 Brugada ECG pattern on 12-lead electrocardiogram with ajmaline test. Annals of Medical Research, Cilt: 28 - Sayı: 1, 144–148. https://ajindex.com/articles/446276

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (12)

  1. Brugada P, Brugada J. Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. A multicenter report. J Am Coll Cardiol 1992;20:1391–96
  2. Antzelevitch C, Brugada P, Borggrefe M, et al. Brugada syndrome: report of the second consensus conference: endorsed by the Heart Rhythm Society and the European Heart Rhythm Association. Circulation 2005;111:659–70
  3. Nademanee K, Veerakul G, Nimmannit S, Chaowakul V, et al. Arrhythmogenic marker for the sudden unexplained death syndrome in Thai men. Circulation 1996;96:2595–600
  4. Tan HL, Hofman N, van Langen IM, et al. Sudden unexplained death: heritability and diagnostic yield of cardiological and genetic examination in surviving relatives. Circulation 2005;112:207–13. 5. van der Werf C, Hofman N, Tan HL, et al. Diagnostic yield in sudden unexplained death and aborted cardiac arrest in the young: the experience of a tertiary referral center in The Netherlands. Heart Rhythm 2010;7:1383–9
  5. Mellor G, Raju H, de Noronha SV, et al. Clinical characteristics and circumstances of death in the sudden arrhythmic death syndrome. Circ Arrhythm Electrophysiol 2014;7:1078-83
  6. Garson A Jr, Dick M 2nd, Fournier A, et al. The long QT syndrome in children. An international study of 287 patients. Circulation 1993;87:1866–72
  7. Kapplinger JD, Tester DJ, Alders M, et al. An international compendium of mutations in the SCN5A encoded cardiac sodium channel in patients referred for Brugada syndrome genetic testing. Heart Rhythm 2010:7:33–46
  8. Hu D, Barajas-Martínez H, Pfeiffer R, et al. Mutations in SCN10A are responsible for a large fraction of cases of Brugada syndrome. J. Am. Coll. Cardiol 2014; 64:66–79
  9. Sarquella-Brugada G, Campuzano O, Arbelo E, et al. Brugada syndrome: clinical and genetic findings. Genet. Med 2016;18:3–12
  10. Coronel R, Casini S, Koopmann TT, et al. Right ventricular fibrosis and conduction delay in a patient with clinical signs of Brugada syndrome: a combined electrophysiological, genetic, histopathologic, and computational study. Circulation 2005;112:2769–77
  11. Tauber PE, Mansilla V, Brugada P, et al. (June 20th 2018). Endocardial approach for substrate ablation in brugada syndrome, cardiac arrhythmias, umashankar lakshmanadoss, intechopen https://www.intechopen. com/books/cardiac-arrhythmias/endocardialapproach- for-substrate-ablation-in-brugadasyndrome
  12. Zhang P, Tung R, Zhang Z, et al. Characterization of