The CRP values of the PA cases on days 2 and 3 were determined to be significantlyhigher than those of the control group (p
📌 3 Key Takeaways
🎯
Objective & Hypothesis:Aim: To investigate the relationship between base deficit (BD) and C-reactive protein (CRP) findings evaluated during diagnosis ofinfants followed up for a diagnosis of perinatal asphyxia (PA).Material and Methods: This prospective observational study included 66 cases as 33 cases treated and followed up for a diagnosisof PA in the Neonatal Intensive Care Unit of Harran University Medical Faculty Hospital, and a control group of 33 healthy infants.Using a syringe washed with heparin, a fetal blood sample of 2ml was taken from the umbilical artery of the neonates thought to havePA, and blood gases were examined in an anaerobic environment.
📊
Key Findings & Data:CRP values were obtained from spectrophotometric biochemicalanalysis of the 2ml blood sample using an Architect C16000 device (Abbott Diagnostics, Abbott Park, IL, USA).Results: Evaluation was made of 33 infants with a diagnosis of PA hospitalised in NICU and a control group of 33 healthy infants.All the cases were statistically similar in respect of gestational week at birth (GW), birthweight (BW), and gender.
💡
Conclusion & Impact:The CRP values of the PA cases on days 2 and 3 were determined to be significantlyhigher than those of the control group (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters
Abstract
Aim: To investigate the relationship between base deficit (BD) and C-reactive protein (CRP) findings evaluated during diagnosis ofinfants followed up for a diagnosis of perinatal asphyxia (PA).Material and Methods: This prospective observational study included 66 cases as 33 cases treated and followed up for a diagnosisof PA in the Neonatal Intensive Care Unit of Harran University Medical Faculty Hospital, and a control group of 33 healthy infants.Using a syringe washed with heparin, a fetal blood sample of 2ml was taken from the umbilical artery of the neonates thought to havePA, and blood gases were examined in an anaerobic environment. CRP values were obtained from spectrophotometric biochemicalanalysis of the 2ml blood sample using an Architect C16000 device (Abbott Diagnostics, Abbott Park, IL, USA).Results: Evaluation was made of 33 infants with a diagnosis of PA hospitalised in NICU and a control group of 33 healthy infants.All the cases were statistically similar in respect of gestational week at birth (GW), birthweight (BW), and gender. In the blood gasexaminations of the cord blood, pH value was determined as mean 6.9 (range, 6.50-7.06), mean BD as 17mmol/L (range, 12-28mmol/L), and CRP values as 0.2-57 mg/dl. The CRP values of the PA cases on days 2 and 3 were determined to be significantlyhigher than those of the control group (p
🔖
Cite This Article
SOLMAZ, A., ASLAN, H., GÜMÜŞ, H., KAZANASMAZ, H. (2022). An investigation of the relationship between base deficit and CRP in asphytic infants. Annals of Medical Research, Cilt: 27 - Sayı: 1, 92–96. https://ajindex.com/articles/446203
M Polat, A Şimşek, N Tansuğ, et al. Prediction of neurodevelopmental outcome in term neonates with hypoxic-ischemic encephalopathy. Eur J Paediatric Neurol 2013;17.3:288-93
Nuñez A, Benavente I, Blanco D, et al. Oxidative stress in perinatal asphyxia and hypoxic-ischaemic encephalopathy. Anales de Pediatría 2018;88:228-9
Papile LA, Baley JE, Benitz W, et al. Hypothermia and neonatal encephalopathy. Committee on Fetus and Newborn, Pediatrics 2014;133:1146 4. Kliegman Robert M. Hypoxic ischemic encephalopathy. Nelson Textbook Of Pediatrics (20th ed) Vol 1 IN: Nervous System Disorders, 2016;99.5:834-42
Aluvaala J, Collins GS, Maina M, et al. A systematic review of neonatal treatment intensity scores and their potential application in low-resource setting hospitals for predicting mortality, morbidity and estimating resource use. Syst Rev 2017;6:248
Hacımustafaoğlu M. Acute Phase Reactants (Erythrocyte Sedimentation Rate, CRP) J Pediatr Inf 2017;11:53-5 7. Perlman JM, Wyllie J, Kattwinkel J, et al. Part 11: neonatal resuscitation: 2010 international consensus on cardiopulmonary resuscitation and emergency cardiovascular care science with treatment recommendations. Circulation 2010;122:516-38
Procianoy RS. Hipotermia terapêutica. SBP. Departamento de Neonatologia. Documento científico cited 2015
Y Gao, R Fu, J Wang, et al. Resveratrol mitigates the oxidative stress mediated by hypoxic-ischemic brain injury in neonatal rats via Nrf2/HO-1 pathway. Pharm Biol 2018;56:440-9
L Merrill. Therapeutic hypothermia to treat hypoxic ischemic encephalopathy in newborns. Nurs Womens Health 2012;16:126-34
Papile LA, Baley JE, Benitz W, et al. Hypothermia and neonatal encephalopathy. Pediatrics 2014;133:1146 12. S McWilliam, A. Riordan. How to use: C-reactive protein. Arch Dis Child Educ Pract Ed 2010;95.2: 55-8
Lally P J, Montaldo P, Oliveira V, et al. Residual brain injury after early discontinuation of cooling therapy in mild neonatal encephalopathy. Arch Dis Child Educ Pract Ed 2018;103:383-7
Aibiki M, Maekawa S, Ogura S, et al. Effect of moderate hypothermia on systemic and internal jugular plasma IL-6 levels after traumatic brain injury in humans. J Neurotrauma 1999;16:225-32
Chakkarapani E, Davis J, Thoresen M. Therapeutic hypothermia delays the C-reactive protein response and suppresses white blood cell and platelet count in infants with neonatal encephalopathy. Arch Dis Child Educ Pract Ed 2014;99:458-63