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Journals / Annals of Medical Research / 2022 / Cilt: 29 - Sayı: 6

Educated platelets promote wound healing via anti-inflammatory effect and down-regulated VEGF and MMP-9

Sefa KURT
Başak BAYKARA
Osman YILMAZ
Fırat YILMAZ
Orkun ILGEN
Pages
569–573
Publication Date
2022-10-12
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Further and more extensive clinical studies are needed to determine the effectiveness of this treatment method definitively.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: This study aims to investigate the effect of educated platelets histological and immunohistochemical (MMP-9 and VEGF) in wound treatment.
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Key Findings & Data:Materials and Methods: 28 female Wistar albino 180-225 gr rats were divided into four groups randomly.
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Conclusion & Impact:Further and more extensive clinical studies are needed to determine the effectiveness of this treatment method definitively.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: This study aims to investigate the effect of educated platelets histological and immunohistochemical (MMP-9 and VEGF) in wound treatment. Materials and Methods: 28 female Wistar albino 180-225 gr rats were divided into four groups randomly. The control group (C) is unburnt which blood samples are extracted or PRP with ordinary platelets. Burn group (B) is a burn group in which blood samples were extracted with the educated platelets for PRP. The Burn and uneducated platelet group (B+P) were the burn groups given PRP with uneducated platelets to their blood circulation. Burn and educated platelet group (B+EP) was the burn group given PRP with educated platelets to their blood circulation. The histological analysis was scored 14 days after injury, and MMP-9, VEGF were immunostained. Results: The results clearly showed higher reepithelialization, lower inflammation, and granulation in the B+EP group. Immunohistochemical staining for MMP-9 and VEGF in the B+EP group were statistically lower than other groups. Educated platelet treatment significantly suppressed MMP-9 and VEGF. Conclusion: Our findings suggest that educated-platelet treatment can be a promising strategy for promoting burn cutaneous wound healing. Further and more extensive clinical studies are needed to determine the effectiveness of this treatment method definitively.

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Cite This Article

KURT, S., BAYKARA, B., YILMAZ, O., YILMAZ, F., ILGEN, O. (2022). Educated platelets promote wound healing via anti-inflammatory effect and down-regulated VEGF and MMP-9. Annals of Medical Research, Cilt: 29 - Sayı: 6, 569–573. https://ajindex.com/articles/445637

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References (1)

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