Journals / Fırat Üniversitesi Sağlık Bilimleri Tıp Dergisi / 2012 / Cilt: 26 - Sayı: 2

Granulosa cell tumor of the ovary in a postmenopausal patient: Report of a case and review of the literature

Postmenopozal dönemde overin granüloza hücreli tümörü: Olgu sunumu ve literatürün gözden geçirilmesi

Pages
93–96
Publication Date
2022-10-18
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Frozen examination of the removed right ovarian mass revealed the diagnosis of granulosa cell tumor.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Granulosa cell tumours (GCT) are uncommon sex cord-stromal tumours of the ovary, and comprise approximately 2-3% of all ovarian malignancies.
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Key Findings & Data:These tumours characteristically have a low malignant potential, and have slow growth rates.
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Conclusion & Impact:Frozen examination of the removed right ovarian mass revealed the diagnosis of granulosa cell tumor.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Granulosa cell tumours (GCT) are uncommon sex cord-stromal tumours of the ovary, and comprise approximately 2-3% of all ovarian malignancies. These tumours characteristically have a low malignant potential, and have slow growth rates. They are hormonally active stromal cell neoplasms that can secrete sex steroids such as estrogen. Serum tumor markers such as estradiol and inhibin are used for diagnosis of GCT. Low serum level of FSH may be useful as a diagnostic marker in postmenopousal period. Patients may present with vaginal bleeding caused by endometrial hyperplasia or uterine cancer as a result of prolonged exposure to tumor-derived estrogen. In this case report, a patient with a painless mass of right ovary and atypical endometrial hyperplasia was presented. Frozen examination of the removed right ovarian mass revealed the diagnosis of granulosa cell tumor.

Özet

Granüloza hücreli tümörler (GHT) overin seks kord stromal tümörleridir ve tüm over malignitelerinin %2-3’ünü oluşturur. Bu tümörler tipik olarak düşük malign potansiyelli, yavaş büyüme hızı ve östrojen gibi seks steroidleri salgılayabilen hormon aktif seks kord stromal tümörlerdir. Serum tümör belirteci olarak inhibin ve östrodiol tanıda kullanılabilir. Postmenopozal dönemde, düşük FSH düzeylerinden de tanısal belirteç olarak yararlanılabilir. Hastaların tümör tarafından uzun süre östrojen salgılanmasına maruz kalması sonucu olarak uterin kanser ve endometrial hiperplazi gelişebilir ve vaginal kanama görülebilir. Bu çalışmada operasyon öncesi atipisiz endometrial hiperplazisi ve sağ ovarian ağrısız kitlesi olan bir olgu sunulmuştur. Operasyon esnasında sağ ovarian kitlenin frozene gönderilmesi sonucu granüloza hücreli over tümörü tanısı konulmuştur.

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Cite This Article

KURT, S., GENÇ, M., TURAN, A., GENÇ, B., KORKUT, B. (2022). Granulosa cell tumor of the ovary in a postmenopausal patient: Report of a case and review of the literature. Fırat Üniversitesi Sağlık Bilimleri Tıp Dergisi, Cilt: 26 - Sayı: 2, 93–96. https://ajindex.com/articles/514705

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