Journals / Ankara Üniversitesi Veteriner Fakültesi Dergisi / 2005 / Cilt: 52 - Sayı: 1

The investigation of the effect of levamisole on rabbit trachea alone and combined witl trichlorfon

Tavşan trakeası üzerine levamizolun etkisinin tek başına ve triklorfonla birlikte araştırılması

Pages
23–28
Publication Date
2022-10-12
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

It was seen that the incubation with levamisole increased the $E_{max}$ value of acetylcholine (p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:The aim of this study is to investigate the effect of levamisole on rabbit trachea, the antagonists of levamisole and reveal the relation between trichlorfon and levamisole.
📊
Key Findings & Data:The cumulative concentrations of levamisole ($10^{-8 - 10^{-3}$ M) were applied to the tracheal ring of rabbit.
💡
Conclusion & Impact:It was seen that the incubation with levamisole increased the $E_{max}$ value of acetylcholine (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

The aim of this study is to investigate the effect of levamisole on rabbit trachea, the antagonists of levamisole and reveal the relation between trichlorfon and levamisole. The cumulative concentrations of levamisole ($10^{-8 - 10^{-3}$ M) were applied to the tracheal ring of rabbit. Bethanecole, carbachol, acetylcholine, trichlorfon, mecamylamine, atropine and nicotin were also studied with levamisole. Levamisole was without considerable effect alone on rabbit trachea. It was seen that the incubation with levamisole increased the $E_{max}$ value of acetylcholine (p

Özet

Bu araştırmada, levamizolun tavşan trakeası üzerine etkisini belirlemek, levamizolun antagonistlerini saptamak, levamizol ile triklprfon arasındaki ilişkiye açıklık kazandırmak amaçlandı. Levamizol ($10^{-8}- 10^{-3}$ M) birikimli derişimlerde ve 5x $10^{-5}$ M derişimde asetilkolin (Ak), karbakol, betanekol, triklorfon, mekamilamin, nikotin ve atropin ile birlikte değişik terkip ve derişimlerde 82 tavşan trakeası üzerinde çalışıldı. Tavşan trakeası üzerine levamizolun tek başına etkisiz olduğu tespit edildi. Levamizol inkübasyonunun Ak'nın $E_{max}$ değerini artırdığı (p

🔖

Cite This Article

YILDIRIM, E. (2022). The investigation of the effect of levamisole on rabbit trachea alone and combined witl trichlorfon. Ankara Üniversitesi Veteriner Fakültesi Dergisi, Cilt: 52 - Sayı: 1, 23–28. https://ajindex.com/articles/445237

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (1)

  1. Adler M, Moore DH, Filbert MG (1992): Mechanism of soman-induced contractions in canine tracheal smooth muscle. Arch Toxicol, 66, 204-210. 2.Aldabagh II, Mohammad FK (1999): Reduction of dichlorvos induced toxicosis in rabbits by levamisole. Erişim: www.vef.hr/vetarhrv/69-l/aldabagh.htm. Erişim tarihi: 20.11.2000 3.Atchison WD, Geary TG, Manning B, Vandewaa EA, Thompson DP (1992): Comparative neuromuscular blocking of levamisole and pyrantel-type antelmintics on rat and gastrointestinal nematode somatic muscle. Toxicol Appl Pharmacol, 112,133-143. 4.Buranakarl C, Kijtawoornnat A, Angkanaporn K, Komolvanich S, Bovee KC (2001): Effects ofbethanecol on canine urinary bladder smooth muscle function. Res Vet Sci, 71,175-181. 5.Caposso F, Moscolo N, Autore G (1982): Enhancement by levamisole of the contractions induced by prostaglandin $E_2$ in the guinea-pig isolated ileum. Prostaglandins, 23, 427-432. 6.Cook WO, Osweller GD, Walter H, Stahi HM (1985: Levamisole toxicosis in swine. Vet Hum Toxicol, 27, 388-389. 7.Einstein R, Jones RS, Knifton A, Starmer, G.A. (1994): Principles of Veterinary Therapeutics. Longman Singapore Publishers Ltd. Singapore. 8.Eyre P (1970): Some pharmacodynamic effects of nematocides: methyridine, tetramisole and pyrantel. J Pharm Pharmac, 22,26-36. 9.Ford EJH, Abdelsalam, EB (1983): Combined effect of levamisole and organophosphorus compounds on calves. Vet Rec, 112,106. 10.Ford EJH, Evans AB (.1987): Combined effect of slow release levamizole on prolate on acethylcholine activity in cattle. Vet Rec, 120, 579-580 11.Gulati OD, Hemevathi K, Joshi DP (1985): Interactions of levamizole with some autonomic drugs on guinea pig vas deferens. J Auton Pharmac, 5, 19-25. 12.Hsu WH (1980): Toxicity and drug interactions of levamisole. JAVMA, 176, 1166-1169. 13.Hsu WH (1981): Drug interactions of levamizole with pyrantel tartrate and dichlorvos in pigs. Am J Vet Res, 42, 1912-1914. 14.Hulsmann AR, De Jongste J C (1993). Studies of human airways in vitro: a review of the methodology. J P M, 30, 117-132. 15.Kaya S (2000): Antelmintikler. 421-477. In: S. Kaya; İ. Pirinci; A, Bilgili (Ed) Veteriner Uygulamalı Farmakoloji Cilt II. Medisan. Ankara. 16.Kayaalp SO (2000): Rasyonel Tedavi Yönünden Tıbbi Farmakoloji. 1. Cilt. 9. Baskı. Hacettepe Taş Kitapçılık Ltd Şti. Ankara. 17.Kurtdede A, Baydan E, Börkü MK, Kalınbacak A. (1992): Köpeklerde tetramizol ve triklorfonun kan parametrelerine etkileri. Ankara Üniv Vet Fak Derg, 39, 168-172 18.Nauailhetas