Journals / Ankara Üniversitesi Veteriner Fakültesi Dergisi / 2008 / Cilt: 55 - Sayı: 1

Bitki büyüme hormonlarının farelerdeki subkronik toksik etkileri

The subchronic toxic effects of plant growth promoters in mice

Pages
17–21
Publication Date
2022-10-12
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Producers and consumers should become more conscious about the toxic effects of these chemicals.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:The aim of this study was conducted to subchronic toxic effects separate and combined using of maleic hydrazide and ethephon in female mice.
📊
Key Findings & Data:Treatment group divided into 9 groups according to chemicals’ doses and compared with controls.
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Conclusion & Impact:Producers and consumers should become more conscious about the toxic effects of these chemicals.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

The aim of this study was conducted to subchronic toxic effects separate and combined using of maleic hydrazide and ethephon in female mice. Treatment group divided into 9 groups according to chemicals’ doses and compared with controls. Three separate maleic hydrazide doses (100-200-400 mg/kg/day, in feed) and ethephon (50-100-150 mg/kg/day, in water) were given alone and in combination during 45 days. At the end of the study, aspartate aminotransferase, alanine aminotransferase, urea and creatinine levels in blood samples were evaluated. Liver and kidney tissues were taken and examined histopathologically. As a result, alone usages of maleic hydrazide caused liver, kidney toxicity. Toxic effects were clearer in liver; however with ethephon, toxicity was more moderate than maleic hydrazide. In combination, glomerulonephritis were seen in the highest doses. As a result, plant growth promoters could be harmful on kidney and liver. Producers and consumers should become more conscious about the toxic effects of these chemicals.

Özet

Bu çalışma, maleik hidrazid ve etefonun tek ve kombine kullanımının dişi farelerdeki subkronik toksik etkilerini değerlendirmek amacıyla yapıldı. Çalışma grupları kimyasal maddelerin dozlarına göre 9 gruba ayrıldı ve bunlar kontrol grubuyla karşılaştırıldı. Maleik hidrazid (100-200-400 mg/kg/gün, yemle) ve etefon (50-100-150 mg/kg/gün, su ile)’nun 3 farklı dozu tek ve kombinasyon şeklinde 45 gün süresince verildi. Çalışmanın sonunda, kan örneklerindeki aspartat aminotransferaz, alanin aminotransferaz, üre ve kreatinin düzeyleri değerlendirildi. Karaciğer, böbrek dokuları alınarak histopatolojik inceleme yapıldı. Maleik hidrazidin tek başına kullanımında karaciğer ve böbrekde toksisiteye sebep olduğu belirlendi. Bu toksisite özellikle karaciğerde daha belirgin olmakla birlikte, etefonun toksistesitesi maleik hidrazidden daha ılımlıydı. Kombinasyonlarda ise, yüksek dozlarda glomerulonefritis görüldü. Sonuç olarak, bitki büyüme hormonları karaciğer ve böbrek üzerinde zararlı etkileri olabilmektedir. Üretici ve tüketicilerin bu kimyasalların toksik etkileri konusunda daha çok bilinçlendirilmesi gerekmektedir.

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Cite This Article

YAZAR, S., BAYDAN, E. (2022). Bitki büyüme hormonlarının farelerdeki subkronik toksik etkileri. Ankara Üniversitesi Veteriner Fakültesi Dergisi, Cilt: 55 - Sayı: 1, 17–21. https://ajindex.com/articles/445090

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References (14)

  1. Durham WF (1967): The interaction of pesticides with other factors. Residue Rev, 18, 21-103
  2. Food and Agriculture Organization (FAO) (2001): FAO specifications and evaluations for agricultural pesticides. Maleic hydrazide. Erişim:[http://www.fao.org/ag/AGP/ AGPP/Pesticid/Specs/docs/Pdf/new/d+e/e maleic.pdf]. Erişim tarihi:31.01.2001
  3. Haux JE, Quistad GB, Casida JE (2000): Phosphobutyrylcholinesterase: phosphorylation of the esteratic site of butyrylcholinesterase by ethephon[(2-chloroethyl)phosphonicacid]dianion. Chem Res Toxicol, 13, 646-651
  4. Haux JE, Lockridge O, Casida JE (2002): Specificity of ethephon as a butyrylcholinesterase inhibitor and phosphorylating agent. Chem Res Toxicol, 15, 1527-1533
  5. International Programme on Chemical Safety (Inchem) (1993):Pesticide residues in food: 1993 evaluations Part II Toxicology. Ethephon. Erişim:[http://www.inchem.org/documents/jmpr/jmpmono/v93pr07.htm]. Erişim tarihi: 23.01.2005
  6. International Programme on Chemical Safety (Inchem) (1996): Pesticide residues in food: 1996 evaluations PART II Toxicology. Maleic Hydrazide. Erişim:[http://www.inchem.org/documents/jmpr/jmpmono/v96pr08.htm].Erişim Tarihi: 20.07.2004
  7. International Programme on Chemical Safety (Inchem) (2002): Pesticide Residues in food-2002- Joint FAO/WHO meeting on Pesticide Residues. Ethephon. Erişim:[http://www.inchem.org/documents/jmpr/jmpmono/2002pr05.htm].Erişim tarihi: 25.07.2004
  8. Marcano L, Carruyo I, Del Campo A, Montiel X (2004): Cytotoxicity and mode of action of maleic hydrazide in root tips of Alliım cepa L. Environ Res, 94, 221-226
  9. Mickel LG (1978): Plant growth regulators: controlling biological behaviour with chemicals. Chem Eng News, 56,18
  10. Ponnampalam R, Mondy NI, Babish JG (1983): A review of environmental and health risks of maleic hydrazide. Regul Toxicol Pharm, 3, 38-47
  11. Segall Y, Grendell RL, Toia RF, Casida JE (1991): Composition of technical ethephon (2-chloroethylphosphonic acid) and some analogs relative to their reactivity and biological activity. J Agric Food Chem, 39, 380-385
  12. Seidler H, Ackermann H, Harting M, Koslowski C (1979): Effect of the phosphonic acid derivatives ethephon and trichlorphon the incorporation in vivo of (14C) acetate into cholesterol and other lipids in rats. Acta Biol Med Ger, 38, 1029-1037
  13. Swietlinska Z, Žuk J (1978):Cytotoxic effects of maleic hydrazide. Mut Res, 55, 15-30
  14. Tagawa H, Tobita T, Matsuzaki TA (1995): Novel metabolite of maleic hydraz