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Journals / Ankara Üniversitesi Veteriner Fakültesi Dergisi / 2016 / Cilt: 63 - Sayı: 3

Effects of ACTH application on kidney function tests, the electrolytes and hematological parameters in rats

Sıçanlarda ACTH uygulamasının böbrek fonksiyon testleri, elektrolitler ve hematolojik parametreler üzerine etkileri

Arzu COMBA
Yıldırım Gökhan GENCER
Bahat COMBA
Ali ÇINAR
Pages
229–233
Publication Date
2022-10-12
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The level of glucose, WBC, monocyte %, granulocyte %, p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:This study was conducted to investigate the effects of ACTH application on kidney function tests, electrolytes, and hematological parameters in rats.
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Key Findings & Data:Each group consisted of 6 male Sprague Dawley rats which were about 13 weeks old and 200-250 g in weight.
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Conclusion & Impact:The level of glucose, WBC, monocyte %, granulocyte %, p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

This study was conducted to investigate the effects of ACTH application on kidney function tests, electrolytes, and hematological parameters in rats. In the research two groups were formed, including control and stress. Each group consisted of 6 male Sprague Dawley rats which were about 13 weeks old and 200-250 g in weight. Serum isotonic was administered at a dose of 0.5 ml/rat to control group, and ACTH was applied at a dose of 4 mg/kg to stress group at once intraperitoneally. Blood samples were taken 3 hours after the application. Concentrations of glucose, amylase, creatine, creatine kinase (CK), creatine kinase MB (CK-MB), urea, uric acid, lactate dehydrogenase (LDH), calcium (Ca), phosphorus (P), magnesium (Mg) sodium (Na), chlorine (Cl) and potassium (K) in serum; the numbers of total leukocytes (WBC), platelet (PLT) and erythrocytes (RBC) and the values of hemoglobin (HGB) and hematocrit (HCT), on whole blood were performed. The level of glucose, WBC, monocyte %, granulocyte %, p

Özet

Bu çalışmada, sıçanlarda ACTH uygulamasının böbrek fonksiyon testlerine, elektrolitlere ve hematolojik parametreler üzerine etkilerini araştırmak amaçlandı. Araştırmada kontrol ve stres olmak üzere iki grup oluşturuldu. Her grupta 6'şar adet yaklaşık 13 haftalık, 200-250 g ağırlığında, Sprague Dawley ırkı erkek sıçan kullanıldı. Kontrol grubuna 0.5 ml serum izotonik/birey, stres grubuna ise 4 mg/kg dozunda ACTH intraperitoneal (i.p.) olarak bir kez uygulandı. Bu uygulamadan 3 saat sonra kan örnekleri alındı. Serumda glukoz, amilaz, kreatinin, kreatin kinaz (CK), kreatin kinaz MB (CK-MB), üre, ürik asit, kan üre azotu (BUN), laktat dehidrojenaz (LDH), kalsiyum (Ca), fosfor (P), magnezyum (Mg), sodyum (Na), klor (Cl), potasyum (K) analizleri, tam kanda ise total lökosit (WBC), eritrosit (RBC), hemoglobin (HGB), hematokrit (HCT), trombosit (PLT) ölçümleri yapıldı. Stres grubunda glukoz, WBC, % monosit ve % granülosit düzeyleri P

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Cite This Article

COMBA, A., GENCER, Y. G., COMBA, B., ÇINAR, A. (2022). Effects of ACTH application on kidney function tests, the electrolytes and hematological parameters in rats. Ankara Üniversitesi Veteriner Fakültesi Dergisi, Cilt: 63 - Sayı: 3, 229–233. https://ajindex.com/articles/444931

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