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Journals / Ankara Üniversitesi Veteriner Fakültesi Dergisi / 2017 / Cilt: 64 - Sayı: 2

Aroclor 1254 ve vitamin E'nin yetişkin, gebe rat ve yavrularında arginaz aktivitesi üzerine etkileri

Effects of Aroclor 1254 and vitamin E on arginase activity in adult, pregnant rats and their offsprings

Mine ERİŞİR
Ayşe DOĞAN
Pages
99–102
Publication Date
2022-10-12
DOI
—
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⚡ TL;DR(Too Long; Didn't Read)

A statistically significant increase was determined in liver arginase activity of adult rats exposed to Aroclor 1254 (p

📌 3 Key Takeaways

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Objective & Hypothesis:This study examined the effect of Aroclor 1254 on arginase activity and protective role of vitamin E among adult rats, pregnant rats and their offsprings.
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Key Findings & Data:Totally 90 Sprague-Dawley rats were divided into three main groups as 30 pregnant, 30 adult and 30 offsprings (pups of the pregnant rats) based on the treatments administered during the pregnancy period (20 days) with subcutaneous daily injections of Aroclor 1254 (2 mg/kg/day) alone or associated with vitamin E (50 mg/kg/day) or normal saline in controls.
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Conclusion & Impact:A statistically significant increase was determined in liver arginase activity of adult rats exposed to Aroclor 1254 (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

This study examined the effect of Aroclor 1254 on arginase activity and protective role of vitamin E among adult rats, pregnant rats and their offsprings. Totally 90 Sprague-Dawley rats were divided into three main groups as 30 pregnant, 30 adult and 30 offsprings (pups of the pregnant rats) based on the treatments administered during the pregnancy period (20 days) with subcutaneous daily injections of Aroclor 1254 (2 mg/kg/day) alone or associated with vitamin E (50 mg/kg/day) or normal saline in controls. Female rats and their offsprings (10 offsprings per groups) were analyzed in terms of the arginase activity in liver. A statistically significant increase was determined in liver arginase activity of adult rats exposed to Aroclor 1254 (p

Özet

Bu çalışmada yetişkin, gebe rat ve yavrularında arginaz aktivitesi üzerine Aroclor 1254'ün etkisi ve vitamin E'nin koruyucu rolü araştırıldı. Toplam 90 Sprague-Dawley rat 30 yetişkin, 30 gebe ve 30 yavru olmak üzere üç ana gruba ayrıldı. Gebelik süresince (20 gün) subkutan olarak Aroclor 1254 (2 mg/kg/gün) tek başına veya vitamin E (50 mg/kg/gün) ile birlikte ve kontrol grubuna serum fizyolojik uygulandı. Dişi ratlar ve onların yavrularının (her gruptan 10 yavru) karaciğerinde arginaz aktivitesi analiz edildi. Aroclor 1254'e maruz kalan yetişkin ratların karaciğer arginaz aktivitesinde anlamlı bir artış (p

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Cite This Article

ERİŞİR, M., DOĞAN, A. (2022). Aroclor 1254 ve vitamin E'nin yetişkin, gebe rat ve yavrularında arginaz aktivitesi üzerine etkileri. Ankara Üniversitesi Veteriner Fakültesi Dergisi, Cilt: 64 - Sayı: 2, 99–102. https://ajindex.com/articles/444661

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References (13)

  1. Agency for Toxic Substances and Disease Registry (ATSDR): Toxicological Profile for Polychlorinated Biphenyls (PCBs) (2000): US Dept Health Services. Public Health Service, Atlanta. Ando M, Saito H, Wakisaka I (1986): Gas chromatographic and mass spectrometric analysis of polychlorinated biphenyls in human placenta and cord blood. Environ Res, 41, 14-22.
  2. Ash DE (2004): Structure and function of arginases. J Nutr, 134, 2760-2767.
  3. Carpenter DO (1998): Polychlorinated biphenyls and human health. Int J Occup Med Environ Health, 11, 291-303.
  4. Carpenter DO, Stoner CT, Lawrence DA, et al. (1996): Multiple mechanisms of PCB neurotoxicity. Proc Pacific Basin Conference on Hazardous Waste. Kuala Lumpur, Malaysia, 404-418.
  5. Chen CJ, Yu ML, Rogan WJ, et al. (1994): A 6-year follow-up of behavior and activity disorders in the Taiwan Yu-cheng children. Am J Public Health, 84, 415-421.
  6. Chrzanowska A, Grabon W, Mielczarek-Puta M, et al. (2014): Significance of arginase determination in body fluids of patients with hepatocellular carcinoma and liver cirrhosis before and after surgical treatment. Clin Biochem, 47, 1056-1059.
  7. Chu I, Villeneuve DC, Yagminas A, et al. (1994): Subchronic toxicity of 3,3',4,4',5-pentachlorobiphenyl in the rat. I. Clinical, biochemical, hematological, and histopathological changes. Fundam Appl Toxicol, 22, 457- 468. Dundar Y, Aslan R (1999): Bir antioksidan olarak vitamin E. Genel Tıp Derg, 9, 109-116.
  8. Ebner K, Couri D (1988): Aroclor 1254 treatment and fasting influences on rat liver mitochondrial carbamoyl phosphate synthesis with ADP and ATP. Toxicol Appl Pharmacol, 96, 75-84.
  9. Ebner KV, Bergen WG, Braselton WE Jr (1987): Nitrogen deficits in aroclor 1254-treated rats. Fundam Appl Toxicol, 8, 89-96.
  10. Erisir M, Beytut E, Ozan S, et al. (2003): Effects of dietary vitamin E and selenium on arginase activity in the liver, kidney and heart of rats treated with high doses of glucocorticoids. Cell Biochem Funct, 21, 331-335.
  11. Gallo-Torres HE (1980): Absorbtion, blood transport and metabolism of vitamin E. 170-267. In: Machlin LJ (Ed), Comprehensive Treatise. Marcel-Decker, New York. Geyer JW, Dabich D (1971): Rapid method for determination of arginase activity in tissue homogenates. Anal Biochem, 39, 412-417.
  12. Hansen LG (1999): The Ortho Side of PCBs. Occurrence and Disposition. Kluwer Academic Publishers,
  13. Boston. Herrera E, Knopp RH, Freinkel N (1969): Carbohydrate metabolism in pregnancy. VI. Plasma fuels, insulin, liver composition, gluconeogenesis and