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Journals / Ankara Üniversitesi Veteriner Fakültesi Dergisi / 2018 / Cilt: 65 - Sayı: 1

Streptozotosin ile tip 1 diyabet oluşturulan sıçanların karaciğerlerinde meydana gelen hasarlarda nitrik oksit ve oksidatif stresin patofizyolojideki rolleri

Role of nitric oxide and oxidative stress in pathophysiology of liver injury in streptozotocin-induced type 1 diabetic rats

Serkan YILDIRIM
Çağdaş DİNÇEL
Oğuz KUL
Pages
39–50
Publication Date
2022-10-12
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Results of the study revealed that levels of 8-OHdG (P

📌 3 Key Takeaways

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Objective & Hypothesis:Type 1 diabetes mellitus (T1DM) is a severe chronic metabolic disorder characterized by hyperglycaemia because of the alterations in insulin secretion or its action.
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Key Findings & Data:In this report, it is aimed to investigate the cytotoxic effects of NO and to evaluate possible interaction with T1DM related hepatopathology.
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Conclusion & Impact:Results of the study revealed that levels of 8-OHdG (P
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Type 1 diabetes mellitus (T1DM) is a severe chronic metabolic disorder characterized by hyperglycaemia because of the alterations in insulin secretion or its action. It is previously shown that hyperglycemia related oxidative stress (OS) and excessive nitric oxide (NO) production may cause severe complications in kidney and brain. In this report, it is aimed to investigate the cytotoxic effects of NO and to evaluate possible interaction with T1DM related hepatopathology. Expression levels of 8-hydroxy-2'deoxyguanosine (8-OHdG), endothelial nitric oxide synthase (eNOS), inducible nitric oxide synthase (iNOS), Cu/Zn superoxide dismutase (SOD1) and glutathione reductase (GR) were examined by immunohistochemistry in liver tissues. Results of the study revealed that levels of 8-OHdG (P

Özet

Tip 1 diyabet (T1D), insülinin salgı veya görevlerinde anormalliklerle karakterize kronik metabolik bir hastalıktır. Daha önceleri diyabetik hayvanlarda, hiperglisemi ile tetiklenen oksidatif stres (OS) ve nitrik oksit (NO) seviyelerindeki patolojik yükselmelerin böbrek ve beyinde şiddetli komplikasyonlara neden olduğunu gösterdik. Bu çalışma NO'in sitotoksik etkisinin ve OS'in T1D ile ilişkili hepatopatolojilerde herhangi bir ilişkinin olup olmadığını tanımlamak için tasarlanmıştır. Bu amaçla 8-hidroksi-2'deoxyguanosine (8-OHdG), endotelyal nitrik oksit sentaz (eNOS), uyarılabilir nitrik oksit sentaz (iNOS), Cu/Zn süperoksit dismutaz (SOD1) ve glutatyon redüktaz (GR) immunoreaktiviteleri karaciğer dokusunda araştırıldı. Çalışmada, 8-OHdG (P

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Cite This Article

YILDIRIM, S., DİNÇEL, Ç., KUL, O. (2022). Streptozotosin ile tip 1 diyabet oluşturulan sıçanların karaciğerlerinde meydana gelen hasarlarda nitrik oksit ve oksidatif stresin patofizyolojideki rolleri. Ankara Üniversitesi Veteriner Fakültesi Dergisi, Cilt: 65 - Sayı: 1, 39–50. https://ajindex.com/articles/444576

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