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Journals / Ankara Üniversitesi Veteriner Fakültesi Dergisi / 2022 / Cilt: 69 - Sayı: 4

Molecular, biochemical, and histopathological effects of long-term low and high-percentage fructose consumption on the liver in rats

Ratlarda uzun süreli düşük ve yüksek doz fruktoz tüketiminin karaciğerde moleküler, biyokimyasal ve histopatolojik etkileri

Hüseyin ÖZKAN
Tuncer KUTLU
Akın YAKAN
Şule Yurdagül ÖZSOY
Pages
409–417
Publication Date
2022-10-12
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In all experimental groups, triglycerides were significantly higher than those of controls (P

📌 3 Key Takeaways

🎯
Objective & Hypothesis:The aim of this study was to investigate the lipogenic and inflammatory effects of low and high percentage fructose solutions in rats.
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Key Findings & Data:Wistar albino rats were fed with fructose solutions for 10 weeks.
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Conclusion & Impact:In all experimental groups, triglycerides were significantly higher than those of controls (P
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

The aim of this study was to investigate the lipogenic and inflammatory effects of low and high percentage fructose solutions in rats. Wistar albino rats were fed with fructose solutions for 10 weeks. The groups were as follows: Cont (Control), F15 (Fructose 15%), F30 (Fructose 30%), and F60 (Fructose 60%). Rats' body weights were measured weekly. Also, lipogenic and inflammatory gene expression levels, biochemical parameters, and histopathological changes in the liver were investigated. After 10 weeks, it was observed that the animals in the F60 were the heaviest, while the animals in the F30 were the lightest. In all experimental groups, triglycerides were significantly higher than those of controls (P

Özet

Bu çalışmanın amacı ratlarda düşük ve yüksek konsantrasyondaki fruktoz solüsyonlarının lipojenik ve inflamatuar etkilerini araştırmaktır. Çalışmada Wistar albino ratlar 10 hafta boyunca fruktoz solüsyonları ile beslenmiştir. Gruplar: Kont (Kontrol), F15 (Fruktoz %15), F30 (Fruktoz %30), F60 (Fruktoz %60) şeklinde olmuştur. Ratların vücut ağırlıkları haftalık olarak ölçülmüştür. Ayrıca lipojenik ve inflamatuvar genlerin ekspresyon seviyeleri, biyokimyasal parametreler ve karaciğerdeki histopatolojik değişiklikler araştırılmıştır. F60 en hafif grupken, F30 en ağır grup olarak belirlenmiştir. Trigliserit seviyeleri tüm deneme gruplarında Kont grubundan önemli ölçüde yüksek olmuştur (P

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Cite This Article

ÖZKAN, H., KUTLU, T., YAKAN, A., ÖZSOY, Ş. Y. (2022). Molecular, biochemical, and histopathological effects of long-term low and high-percentage fructose consumption on the liver in rats. Ankara Üniversitesi Veteriner Fakültesi Dergisi, Cilt: 69 - Sayı: 4, 409–417. https://ajindex.com/articles/444384

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