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Journals / Ankara Üniversitesi Veteriner Fakültesi Dergisi / 2022 / Cilt: 69 - Sayı: 1

Some inherited disorders in pacing horses in Turkey

Türkiye’deki Rahvan atlarında bazı kalıtsal bozukluklar

Ceyhan ÖZBEYAZ
Banu YÜCEER ÖZKUL
Pages
43–49
Publication Date
2022-10-12
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

It was determined that there are no mutant genes in indigenous pacing horses, in terms of PSSM and SCID disorders, which are the major hereditary disorders in horses.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:This study was carried out to detect the presence of mutant alleles of polysaccharide storage myopathy (PSSM) and severe combined immunodeficiency (SCID) disorders in pacing horses raised in different regions of Turkey.
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Key Findings & Data:Blood/hair samples from 264 (182 Indigenous, 31 Iranian, 24 Afghan, and 27 Bulgarian) pacing horses aged 4 and over were used.
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Conclusion & Impact:It was determined that there are no mutant genes in indigenous pacing horses, in terms of PSSM and SCID disorders, which are the major hereditary disorders in horses.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

This study was carried out to detect the presence of mutant alleles of polysaccharide storage myopathy (PSSM) and severe combined immunodeficiency (SCID) disorders in pacing horses raised in different regions of Turkey. Blood/hair samples from 264 (182 Indigenous, 31 Iranian, 24 Afghan, and 27 Bulgarian) pacing horses aged 4 and over were used. As a result of the study, a mutation-heterozygosis (GA) in the GYS1 gene related to PSSM disease was detected in one of the pacing horses (Bulgarian horse). No deletions were observed in the DNA-PKcs gene region in the pacing horses for SCID disease. This study has been carried out to identify the status of two inherited disorders in pacing horses in Turkey. It was determined that there are no mutant genes in indigenous pacing horses, in terms of PSSM and SCID disorders, which are the major hereditary disorders in horses.

Özet

Bu çalışma, Türkiye’de farklı yörelerde halk elinde yetiştirilen ve Rahvan koşularına katılan atlarda polisakkarid depolama miyopatisi (PSSM) ve şiddetli bileşik immun yetersizlik (SCID) hastalıkları bakımından mutant allel varlığının araştırılması amacıyla yapılmıştır. Bunun için 4 yaş ve üzeri 264 (182 Yerli, 31 İran, 24 Afgan ve 27 Bulgar) rahvan atın kan/kıl örnekleri kullanılmıştır. Çalışma sonucunda, incelenen Rahvan atlarından bir tanesinde (Bulgar rahvan atında) PSSM hastalığı ile ilgili GYS1 geninde mutasyon-heterozigotluk (GA) tespit edilmiştir. SCID hastalığına ilişkin, çalışmada kullanılan rahvan atlarında DNA-PKcs gen bölgesinde delesyon gözlenmemiştir. Sonuç olarak bu çalışma, Türkiye’deki rahvan atlarında bu iki kalıtsal hastalığın durum tespitine yönelik olarak gerçekleştirilmiştir ve bu çalışmada, at yetiştiriciliğinde önemli kalıtsal bozukluklardan ikisi olan PSSM ve SCID hastalıkları açısından yerli rahvan atlarında zararlı genlerin bulunmadığı tespit edilmiştir.

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Cite This Article

ÖZBEYAZ, C., ÖZKUL, B. Y. (2022). Some inherited disorders in pacing horses in Turkey. Ankara Üniversitesi Veteriner Fakültesi Dergisi, Cilt: 69 - Sayı: 1, 43–49. https://ajindex.com/articles/444347

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