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Journals / Ankara Üniversitesi Tıp Fakültesi Mecmuası / 1999 / Cilt: 52 - Sayı: 1

Nucleolar organizer regions (NORs) in prostatic lesions, comparison with tumor grade, stage and prostatic spesific antigen density (PSAD) in prostate adenocarcinoma

Prostatik lezyonlarda nukleolar organizer regions (NORs) değerinin yeri ve prostat adenokanserinde tümör evre, grade ve prostat spesifik antijen dansitesi (PSAD) ile karşılaştırılması

Handan ÖZDEMİR
Kadir TÜRKÖLMEZ
Murat BOZLU
Sadettin KÜPELİ
Pages
27–31
Publication Date
2022-10-10
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Mean AgNOR count was significantly higher (p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Tumor differentiation and proliferative activity are important predictors of biological behavior while routine histological evaluation is fairly adequate to assess differentiation, tumor proliferative activity is difficult to measure.
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Key Findings & Data:Silver-stained nucleolar organizer regions (AgNORs) were studied in 19 hyperplasic, 31 intra-epithelial neoplastic and 30 malignant prostatic lesions.
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Conclusion & Impact:Mean AgNOR count was significantly higher (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Tumor differentiation and proliferative activity are important predictors of biological behavior while routine histological evaluation is fairly adequate to assess differentiation, tumor proliferative activity is difficult to measure. Silver staining for nucleolar organizer regions (AgNORs) is reported to be helpful for assessing tumor differentiation. Silver-stained nucleolar organizer regions (AgNORs) were studied in 19 hyperplasic, 31 intra-epithelial neoplastic and 30 malignant prostatic lesions. The mean AgNOR count per case was calculated. Mean AgNOR count was significantly higher (p

Özet

Tümör diferansiyasyonu ve proliferatif aktivitesi, tümörün biyolojik davranışının önemli göstergeleridir. Rutin histolojik değerlendirmelerle bu parametrelerin ölçümü yetersiz olmaktadır. Silver staining nucleolar organizer regions (AgNOR) tümörün diferansiasyonunun ölçümünde yardımcı bir yöntemdir. Ondokuz hiperplastik, 31 intraepiteliyal neoplastik (PIN) ve 30 malign prostatik lezyonu olan vakada AgNOR metodu çalışılmıştır. Her vaka için ortalama AgNOR değerleri hesaplanmıştır. BPH'lı vakalarla karşılaştırıldığında, PIN ve prostat kanserli (Prostat Ca) gruplarda ortalama AgNOR değeri belirgin olarak yüksek bulunmuştur (p

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Cite This Article

ÖZDEMİR, H., TÜRKÖLMEZ, K., BOZLU, M., KÜPELİ, S. (2022). Nucleolar organizer regions (NORs) in prostatic lesions, comparison with tumor grade, stage and prostatic spesific antigen density (PSAD) in prostate adenocarcinoma. Ankara Üniversitesi Tıp Fakültesi Mecmuası, Cilt: 52 - Sayı: 1, 27–31. https://ajindex.com/articles/444256

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