AI Summary & Key Takeaways
AI InsightPlatelet aggregation that was evaluated as maximal rate of aggregation and maximal extent of aggregation was significantly higher (p
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Abstract
In spite of clinical observations that indicate increased frequency of thromboembolic events and autopsy findings in patients with Beta-Thalassemia Major, several studies all of which were performed in platelet rich plasma samples have reported that response of platelet aggregation to agonists is reduced in these cases. In the present study, responses of platelet aggregation and secretion were examined in the whole blood samples from 21 patients with Beta-Thalassemia Major and 13 age-matched healthy individuals using 3 different agonists (collagen, ADP and thrombin). Platelet aggregation that was evaluated as maximal rate of aggregation and maximal extent of aggregation was significantly higher (p
Özet
Beta-Thalassemia Majorlu olgularda tromboembolik olaylara eğilimin arttığı şeklindeki klinik gözlemler ve otopsi bulgularına karşın, bugüne dek tümü trombositten zengin plazma örneklerinde gerçekleştirilmiş olan az sayıda araştırmada bu olgularda trombosit agregasyon yanıtında azalma saptandığı bildirilmektedir. Sunulan araştırmada trombosit agregasyon ve ATP sekresyonu yanıtları, Beta-Thalassemia Majorlu 21 olgu ve aynı yaş grubundan 13 sağlıklı bireyden alınan tam kan örneklerinde 3 farklı agonist (kollajen, ADP ve trombin) kullanılarak incelenmiştir. Maksimum agregasyon hızı ve maksimum agregasyon büyüklüğü açısından değerlendirilen trombosit agregasyonu Beta-Thalassemia Majorlu olgularda önemli oranda yüksek (p