SavedAdd your journal

Journals / Ankara Üniversitesi Tıp Fakültesi Mecmuası / 2000 / Cilt: 53 - Sayı: 2

Adherence of Mycoplasma pneumoniae to human alveolar macrophages

M. pneumoniae' nin insan alveoler makrofajlarına tutunması

Aydın KARAARSLAN
Özlem ÖZDEMİR
İlkay BOYACIOĞLU
Pages
95–98
Publication Date
2022-10-10
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In this study, it was concluded that the human alveoler macrophages may elicit a protective response agaiııst M. pneumoniae infection, and ELISA is easy and simple method in adherence and phagocytosis studies.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Attachment to alveoler macrophages of M. pneumoniae M129 strain which is HA positive and glass-.adhering and M. pneumoniae FH strain which does not show these features was investigated by ELISA.
📊
Key Findings & Data:It was determined that the glass-adhering, and HA pozitive M. pneumoniae M 129 strain was attached more to human alveoler macrophages when compared with the non glass-adhering and HA negative M. pneumoniae FH strain and the treatment of the bacteria with normal human serum was enhanced the attachment of both strain.
💡
Conclusion & Impact:In this study, it was concluded that the human alveoler macrophages may elicit a protective response agaiııst M. pneumoniae infection, and ELISA is easy and simple method in adherence and phagocytosis studies.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Attachment to alveoler macrophages of M. pneumoniae M129 strain which is HA positive and glass-.adhering and M. pneumoniae FH strain which does not show these features was investigated by ELISA. It was determined that the glass-adhering, and HA pozitive M. pneumoniae M 129 strain was attached more to human alveoler macrophages when compared with the non glass-adhering and HA negative M. pneumoniae FH strain and the treatment of the bacteria with normal human serum was enhanced the attachment of both strain. In this study, it was concluded that the human alveoler macrophages may elicit a protective response agaiııst M. pneumoniae infection, and ELISA is easy and simple method in adherence and phagocytosis studies.

Özet

Hemadsorbsiyon pozitif (HA+) ve cam yüzeylere tutunabilen MP129 M. pneumoniae suşıı ile bu özellikleri göstermeyen M. pneumoniae FH suşunun insan alveoler makrofajlarına tutunmaları ELISA yöntemi ile araştırılmıştır. HA+ M. pneumoniae suşlarının hemadsorbsiyon negatif (HA-) olanlara göre makrofajlara daha fazla bağlandıkları ve opsonizasyonun tutunmayı olumlu yönde etkilediği tespit edilmiştir. Bu çalışmada, M. pneumoniae infeksiyonundan korunmada alveoler makrofajların bir savunma aracı olduğu ve aderans ve fagositoz çalışmalarında ELISA'nın daha kolay ve basit bir teknik olduğu sonu c una varılrnıştır.

🔖

Cite This Article

KARAARSLAN, A., ÖZDEMİR, Ö., BOYACIOĞLU, İ. (2022). Adherence of Mycoplasma pneumoniae to human alveolar macrophages. Ankara Üniversitesi Tıp Fakültesi Mecmuası, Cilt: 53 - Sayı: 2, 95–98. https://ajindex.com/articles/444206

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (16)

  1. Foy H, Kenny CE, Coony MK, Allan İD: Long-term epidemiology of infections vvith Mycoplasma pneumoniae. J Infect Dis 1979; 139: 248-254
  2. Taylor-Robinson D and Braudbury J: Mycoplasma Diseases. İn: Collier L, Balovvs A, Susuma Max, eds. Topley and Wİlson Microbiology and Microbial İnfections. 9th ed. London, Hodder Head line Group. 1998; 1014-1037
  3. Collier AM and Baseman JB: Organ culture techniques vvith mycoplasmas. Ann N Y Acad Sci 1973; 225: 277-289
  4. Cole BC: Mycoplasma interactions vvith the immun system: Implications for disease pathology. ASM Nevvs 1996; 62: 471-475
  5. Povvell DA, Hu PC, Wilson M, Collier AM, Baseman JB: Attachment of Mycoplasma pneumorıiae to respiratory epithelium. Infect İmmun 1976; 13: 959-966
  6. Razin S: Mycoplasma adherence. İn: The Mycoplasmas-Mycoplasma Pathogenicity. Razin S, Barile MF, eds. Vol IV. USA. Academic Press-lnc, 1985: 161-202
  7. Soheslavsky O, Prescott B, Chanock RM: Adsorbtion of Mycoplasma pneumoniae to neuraminic acid receptors of various cells and possible role in virulance. J Bacteriol 1968; 96: 695-705
  8. Krause DC, Leith DK, Wilson RM, Baseman JB: Identification of Mycoplasma pneumoniae proteins associated vvith hemadsorbsion and virulance. Infect İmmun 1982; 35: 809-817
  9. Kahane I: İn vitro studies on the mechanism of adherence and pathogenicity of mycoplasmas. Isr J Med Sci 1977; 20: 874-877
  10. Kahane I, Tucker S, Leith DK, Morrison-Plummer J, Baseman JB: Detection of majör adhesin (P1) in triton shells of virulent Mycoplasma pneumoniae. Infect İmmun 1985;50:944-946
  11. Roberts DD, Olson LD, Barile MF, Cinsburg V, Krivan HC: Sialic acid-dependent adhesion of Mycoplasma pneumoniae to purified glycoproteins. J Biol Chem 1989; 264: 9289-9293
  12. Hovvard CJ, Taylor G: Humoral and cell-mediated immunity. İn: The mycoplasmas. Razin S and Barile MF, eds. Vol IV. London. Academic Press, 1986; 259-292
  13. Gali ily R, Avion A, Jahns-Streubel G, Mühlradt DF: Activation of macrophages and monocytes by Mycoplasmas in: Molecular and Diagnostic Procedures in Mycoplasmology. Razin S and Tully JG, eds. Vol I. London. Academic Press,, 1995; 471-438
  14. Bredt W: Phagocytosis by macrophages of Mycoplasma pneumoniae after opsonization by complement. Infect Immun 1975; 12: 694-695
  15. Athamna A, Kramer MR, Kahane I: Adherence of Mycoplasma to human alveoler macrophages. FEMS Immunol Med Microbiol 1996; 15: 135-141
  16. Krause DC and Baseman JB: Mycoplasma pneumoniae proteins that selectively bind to h