Journals / Ankara Üniversitesi Tıp Fakültesi Mecmuası / 2007 / Cilt: 60 - Sayı: 1

Obez çocuklarda artmış oksidatif stres

Increased oxidative stress ın obese children

Pages
26–30
Publication Date
2022-10-10
DOI
—
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⚡ TL;DR(Too Long; Didn't Read)

Results: Obese group had significantly higher fasting plasma insulin, fasting plasma glucose, plasma cholesterol, LDL-cholesterol and increased blood pressure values as compared to controls (p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aim: Obesity is associated with enhanced lipid peroxidation.
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Key Findings & Data:Materials and Methods: Thirty two children with obesity and 20 age-matched non-obese children were evaluated.
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Conclusion & Impact:Results: Obese group had significantly higher fasting plasma insulin, fasting plasma glucose, plasma cholesterol, LDL-cholesterol and increased blood pressure values as compared to controls (p
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: Obesity is associated with enhanced lipid peroxidation. Malondialdehyde (MDA), one of several by-products of lipid peroxidation process, is a biomarker that provides an indication of lipid peroxidation level. It was aimed to determine the oxidant damage in obese children. Materials and Methods: Thirty two children with obesity and 20 age-matched non-obese children were evaluated. None of the subjects were receiving any medication that could affect insulin levels, insulin sensitivity, or oxidative stress. After overnight fasting, blood was drawn from an antecubital vein for determination of biochemical parameters and MDA levels. Insulin resistance was assessed at baseline by using the homeostasis model assessment (HOMA). Results: Obese group had significantly higher fasting plasma insulin, fasting plasma glucose, plasma cholesterol, LDL-cholesterol and increased blood pressure values as compared to controls (p

Özet

Amaç: Obezite artan lipid peroksidasyonu ile ilişkilidir. Lipid peroksidasyon sürecinin birkaç yan ürününden biri olan malondialdehid (MDA), lipid peroksidasyon düzeyini yansıtan biyolojik bir belirteçtir. Bu çalışmada obez çocuklarda oksidan hasarın belirlenmesi amaçladı. Gereç ve Yöntem: Otuz iki çocuk ve aynı yaş grubunda yirmi obez olmayan çocuk değerlendirildi. Olguların hiçbiri insülin düzeyini, insülin duyarlılığını veya oksidatif stresi etkileyecek ilaç almıyordu. Gece açlışı sonrası biyokimyasal parametreleri ve MDA düzeyini belirlemek için kan alındı. İnsülin direnci HOMA-IR kullanılarak değerlendirildi. Bulgular: Obez grup kontrol grubuyla karşılaştırıldığında anlamlı olarak yüksek açlık plazma insülin, açlık plazma glukozu, plazma kolesterolü, LDL-kolesterol ve yüksek kan basıncı değerlerine sahipti (p

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Cite This Article

YILMAZ, F. M., TOPKAYA, Ç., ERDEVE, Ş. S., DALLAR, Y. (2022). Obez çocuklarda artmış oksidatif stres. Ankara Üniversitesi Tıp Fakültesi Mecmuası, Cilt: 60 - Sayı: 1, 26–30. https://ajindex.com/articles/444127

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