Journals / Ankara Üniversitesi Tıp Fakültesi Mecmuası / 2011 / Cilt: 64 - Sayı: 3

Leptin in malign pleural efusions: May be a new marker?

Malign plevral efüzyonlarda leptin: Yeni bir markır olabilir mi?

Pages
127–132
Publication Date
2022-10-10
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Results: The leptin levels in serum and pleural effusions in group with malignant pleural effusion were significantly higher than both the non-malignant effusion and control groups (p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: The pleural effusions may be caused by malignant or benign diseases.
📊
Key Findings & Data:Methods: Patients with non-malignant (n=20) and malignant pleural effusions (n=20), and healthy control group (n=20) were included in this cross-sectional study.
💡
Conclusion & Impact:Results: The leptin levels in serum and pleural effusions in group with malignant pleural effusion were significantly higher than both the non-malignant effusion and control groups (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: The pleural effusions may be caused by malignant or benign diseases. In this study, it was aimed to determine the serum and pleural leptin levels in non-malignant and malignant pleural effusions. Methods: Patients with non-malignant (n=20) and malignant pleural effusions (n=20), and healthy control group (n=20) were included in this cross-sectional study. The age and body mass index (BMI) were comparative between study groups. The serum leptin levels in all subjects and pleural effusions leptin level in patients with pleural effusion were determined. Leptin levels were compared in terms of study groups and gender of subjects. Results: The leptin levels in serum and pleural effusions in group with malignant pleural effusion were significantly higher than both the non-malignant effusion and control groups (p

Özet

Amaç: Bazı malign ve benign hastalıklar plevral efüzyona yol açabilir. Bu çalışmada, malign ve malign olmayan plevral efüzyonlarda, serum ve plevral sıvıda leptin düzeyleri arasındaki farkı araştırmayı amaçladık. Yöntemler: Çalışmaya yaş ortalaması ve vücut kitle indeksi (VKI) benzer olan malign (n=20), malign olmayan plevral efüzyonlu (n=20) hastalar ve sigara içmeyen sağlıklı bireyler (n=20, kontrol grubu) alındı. Çalışmaya alınan 3 grupta serumda leptin, plevral efüzyonlu hasta gruplarında ise plevral sıvıda leptin düzeylerine bakıldı. Bulgular: Malign plevral efüzyonlu hasta grubunda hem kontrol hem de malign olmayan plevral efüzyonlu hasta grubuna göre serum ve plevral sıvı leptin düzeylerinin anlamlı olarak yüksek olduğu görüldü (p

🔖

Cite This Article

ARDIÇ, S., SEVER, Ö., DİLLİ, A., DİKMEN, G., SAYGIDEGER, Y., DURU, S., SÖNMEZ, Z. (2022). Leptin in malign pleural efusions: May be a new marker?. Ankara Üniversitesi Tıp Fakültesi Mecmuası, Cilt: 64 - Sayı: 3, 127–132. https://ajindex.com/articles/443783

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (15)

  1. Gürkök S, Genç O. Malignant pleural effusion. Turkiye Klinikleri J Surg Med Sci 2006; 2: 37-41. Light RW. Pleural effusion. N Eng J Med 2002; 346: 1971-7.
  2. Yokoyama A, Maruyama M, Ito K. Interluekin 6 activity in pleural effusion. Chest 1992; 102: 1055-9.
  3. Kiropoulus TS, Kostikos K, Oikonomidi S. Acute phase markers for the differeantiation of infectious and malignant pleural effusions. Respir Med 2007; 101: 910-8.
  4. Bunatova K, Obermajer N, Kotyza J, at al. Levels of cathepsine S and H in pleural fluids of inflammatory and neoplastic origin. Int J Biol Markers 2009; 24:47-21.
  5. Iwagava K, Numata Y, Katsuura G. Structurefunction studies of human leptin. J Biol- Chem, 1998; 273: 35245-9.
  6. Gong DW, Bi S, Pratley RE, Weintraub BD, at al. Genomic structure and promoter analysis of the human obese gene. J BiolChem 1996; 271: 3971-4.
  7. Zhang Y, Proenca R, Maffei M, et al. Positional cloning of the Mouse obese gene and its human homologue. Nature 1994: 372: 425-32.
  8. Pelleymounter MA, Cullen MJ, Baker MB, at al. Effects of the obese gene product on body weight regulation in ob/ob mice. Science 1995; 269: 540-3.
  9. Kamohara S, Burcelin R, Halaas JL., et al Acute stimülation of glucose metabolism in mice by leptin treatments. Nature 1997; 389: 374-7. Ergün A. Adipose tissue and the adipocyte: review. Turkiye Klinikleri J Med Sci 2005; 25: 412-20. Ergün A. Leptin. Turkiye Klinikleri J Med Sci 1999; 19: 130-6. Emral R. Adiponectin and other cytokines: medical education. Turkiye Klinikleri J Med Sci 2006; 26: 409-20.
  10. Magni P, Vettor Pagano C, Calcagno A, et al. Expression of a leptin receptor in immortalised gonadotropin-releasing hormone secreting neurons. Endocrinology 1999; 140: 1581-5.
  11. Chehab FF, Lim ME, Lu R. Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nat Genet 1996; 12: 318-20.
  12. Bennet BD, Solar GP, Yuan JO, et al. A role for leptin and its cognate receptor in haematopoiesis. Curr Biol 1996; 6: 1170-80.
  13. Lord GM, Matarese G, Howard JK, et al. Leptin modulaters the T cell immune response and reverses starvation induced immunosuppression. Nature 1998; 394: 897- 901. Bouloumie A, Dresler HCA, Lafontan M. Leptin, the product of the Ob gene promotes angiogenesis. Circ Res 1998; 83: 1059-66.
  14. Bado A, Levasseur S, Le Marchand-Brustel Y, et al. The Stomach is a source of leptin. Nature 1998; 394: 790-3.
  15. Iwaniec UT, Heaney RP, Cullen DM, et al. Leptin increases the number of mineralized bone nodules in vitro. J Bon