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Journals / Ankara Üniversitesi Tıp Fakültesi Mecmuası / 2018 / Cilt: 71 - Sayı: 2

A Potantiel Marker of in-Stent Restenosis: Platelet Distribution Width/Platelet Ratio

Stent Restenozunu Öngörmede Potansiyel Bir Belirteç: Platelet Dağılım Aralığı/Platelet Oranı

Serkan ÇAY
Firdevs Ayşenur EKİZLER
Pages
123–129
Publication Date
2022-10-10
DOI
—
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⚡ TL;DR(Too Long; Didn't Read)

The preprocedural PDW/ platelet ratios were significantly higher in patients that had ISR (odds ratio, 3.43; 95% confidence interval, 2.02-5.83; p

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: Platelets play significant role in the pathogenesis of in-stent restenosis (ISR).
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Key Findings & Data:Materials and Methods: We retrospectively analyzed clinical, biochemical, and angiographic data from 763 consecutive patients [mean age 60.3±10.2 years, 546 (71%) male]; all patients had undergone elective bare-metal stent implantation and further control coronary angiography owing to angina pectoris or ischemia.
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Conclusion & Impact:The preprocedural PDW/ platelet ratios were significantly higher in patients that had ISR (odds ratio, 3.43; 95% confidence interval, 2.02-5.83; p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: Platelets play significant role in the pathogenesis of in-stent restenosis (ISR). Platelet distribution width to platelet count ratio (PDW/ platelet) is a new marker. There are no data available regarding the predictive role of PDW/platelet ratio for ISR in patients with coronary artery disease. The present study aimed to search the predictive value of preprocedural PDW/platelet ratio on in-stent restenosis in patients with stable or unstable angina pectoris undergoing coronary bare-metal stent implantation. Materials and Methods: We retrospectively analyzed clinical, biochemical, and angiographic data from 763 consecutive patients [mean age 60.3±10.2 years, 546 (71%) male]; all patients had undergone elective bare-metal stent implantation and further control coronary angiography owing to angina pectoris or ischemia. Results: The mean period between stent implantation and control coronary angiography procedures was 15.3±8.7 months. The preprocedural PDW/ platelet ratios were significantly higher in patients that had ISR (odds ratio, 3.43; 95% confidence interval, 2.02-5.83; p

Özet

Amaç: Plateletlerin in-stent restenoz (İSR) patogenezinde önemli rolleri vardır. Platelet dağılım aralığının platelet sayısına oranı (PDW/platelet) yakınzaman önce ortaya çıkan bir belirteçtir. Bu oranın koroner arter hastalığında stentrestenozunu öngörmedeki prediktif değeriyle ilgili veri yoktur.Çalışmamızda bu nedenle kararlı veya karasız anjina nedeniyle çıplak metal stent takılan hastalarda prosedür öncesi bakılan PDW/platelet oranınınİSR’nin öngörmedeki rolünü araştırmayı amaçladık.Gereç ve Yöntem: Çalışmamızda elektif çıplak metal stent takılan ve anjina ya da iskemi nedeniyle nedeniyle kontrol anjiografileri yapılan toplam763 ardışık hastanın [ortalama yaş 60,3±10,2 yıl, 546 (%71) erkek]; klinik, biyokimyasal ve anjiyografik verilerini retrospektif olarak inceledik.Bulgular: Stent implantasyonu ve kontrol koroner anjiyografi arasındaki zaman periyodu ortalama 15,3±8,7 aydı. Prosedür öncesi bakılan PDW/platelet oranı İSR olan hastalarda anlamlı olarak daha yüksekti (odds ratio, 3,43; %95 güven aralığı, 2,02-5,83; p

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Cite This Article

ÇAY, S., EKİZLER, F. A. (2022). A Potantiel Marker of in-Stent Restenosis: Platelet Distribution Width/Platelet Ratio. Ankara Üniversitesi Tıp Fakültesi Mecmuası, Cilt: 71 - Sayı: 2, 123–129. https://ajindex.com/articles/443656

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References (14)

  1. Jukema JW, Ahmed TA, Verschuren JJ, et al. Restenosis after PCI. Part 2: prevention and therapy. Nat Rev Cardiol 2011;9:79-90.
  2. Jukema JW, Verschuren JJ, Ahmed TA, et al. Restenosis after PCI. Part 1: pathophysiology and risk factors. Nat Rev Cardiol 2011;9:53-62.
  3. Liu MW, Roubin GS, King SB 3rd. Restenosis after coronary angioplasty. Potential biologic determinants and role of intimal hyperplasia. Circulation 1989;79:1374-1387.
  4. Welt FG, Rogers C. Inflammation and restenosis in the stent era. Arterioscler Thromb Vasc Biol 2002;22:1769-1776.
  5. Gardiner EE, Andrews RK. Structure and function of platelet receptors initiating blood clotting. Adv Exp Med Biol 2014;844:263-275.
  6. Gasparyan AY, Ayvazyan L, Mikhailidis DP, et al. Mean platelet volume: a link between thrombosis and inflammation? Curr Pharm Des 2011;17:47-58.
  7. Golebiewska EM, Poole A. Platelet secretion: From haemostasis to wound healing and beyond. Blood Rev 2015;29:153-162.
  8. Chandrasekar B, Tanguay JF. Platelets and restenosis. J Am Coll Cardiol 2000;35:555-562.
  9. Inoue T, Sohma R, Miyazaki T, et al. Comparison of activation process of platelets and neutrophils after coronary stent implantation versus balloon angioplasty for stable angina pectoris. Am J Cardiol 2000;86:1057-1062.
  10. Huczek Z, Filipiak KJ, Kochman J, et al. Baseline platelet size is increased in patients with acute coronary syndromes developing early stent thrombosis and predicts future residual platelet reactivity. A case-control study. Thromb Res 2010;125:406-412.
  11. Huczek Z, Kochman J, Filipiak KJ, et al. Mean platelet volume on admission predicts impaired reperfusion and long-term mortality in acute myocardial infarction treated with primary percutaneous coronary intervention. J Am Coll Cardiol 2005;46:284-290.
  12. Norgaz T, Hobikoglu G, Aksu H, et al. The relationship between preprocedural platelet size and subsequent in-stent restenosis. Acta Cardiol 2004;59:391- 395. Ranjith MP, Divya R, Mehta VK, et al. Significance of platelet volume indices and platelet count in ischaemic heart disease. J Clin Pathol 2009;62:830- 833. Vagdatli E, Gounari E, Lazaridou E, et al. Platelet distribution width: a simple, practical and specific marker of activation of coagulation. Hippokratia 2010;14:28-32.
  13. Korovesis S, Fredericks S, Holt D, et al. Release of platelet activation markers during coronary angioplasty. Coron Artery Dis 2000;11:391-398.
  14. Purbiya P, Golwala ZM, Manchanda A, et al. Platelet Distribution Width to Platelet Count Ratio as an Index of Severit