Journals / Ankara Eğitim ve Araştırma Hastanesi Tıp Dergisi / 2015 / Cilt: 48 - Sayı: 1

PERIODIC FEVER, APHTHOUS STOMATITIS, PHARYNGITIS AND CERVICAL ADENITIS (PFAPA) SYNDROME

PERİYODİK ATEŞ, AFTÖZ STOMATİT, FARENJİT VE SERVİKAL LENFADENOPATİ (PFAPA) SENDROMU

Pages
33–41
Publication Date
2022-10-11
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In this article, we provide information about the current approaches of PFAPA syndrome

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Fever is the body temperature that is 1-4ºC higher than the average (37ºC) and varies by the place of measurement.
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Key Findings & Data:When there is no explanation of any disease; the attack of fever intervals are at least 7 days, fever episodes from 3 or more with higher than 38.4ºC of body temperature within six months of period is defined as periodic fever syndromes.
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Conclusion & Impact:In this article, we provide information about the current approaches of PFAPA syndrome
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Fever is the body temperature that is 1-4ºC higher than the average (37ºC) and varies by the place of measurement. Fever, which is commonly seen in children, is one of the symptoms that suggests infection firstly. When there is no explanation of any disease; the attack of fever intervals are at least 7 days, fever episodes from 3 or more with higher than 38.4ºC of body temperature within six months of period is defined as periodic fever syndromes. Periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) syndrome is the most common disease in this group. In this article, we provide information about the current approaches of PFAPA syndrome

Özet

Ateş, ölçüldüğü yere göre değişmekle birlikte, vücut sıcaklığının ortalama 37ºC'den 1-4ºC daha yüksek olmasıdır. Çocuklarda sık görülen ateş, öncelikle enfeksiyonu akla getiren semptomlardan biridir. Ateşi açıklayacak bir hastalığın saptanamaması kaydıyla, altı ay içinde atak aralarının en az 7 gün olduğu, 3 veya daha fazla 38.4ºC'den yüksek ateş ataklarının olması, periyodik ateş sendromları olarak tanımlanmaktadır. Periyodik ateş, aftöz stomatit, farenjit ve servikal lenfadenopati (PFAPA) sendromu bu grup içinde en sık görülen hastalıktır. Bu yazıda PFAPA sendromu ile ilgili güncel bilgilere yer verilmiştir

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Cite This Article

MALBORA, B., GÖKASLAN, F. (2022). PERIODIC FEVER, APHTHOUS STOMATITIS, PHARYNGITIS AND CERVICAL ADENITIS (PFAPA) SYNDROME. Ankara Eğitim ve Araştırma Hastanesi Tıp Dergisi, Cilt: 48 - Sayı: 1, 33–41. https://ajindex.com/articles/441416

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References (16)

  1. Clifford B. Saper, and Christopher D. Breder, The Neurologic Basis of Fever. NEJM. 1994
  2. Patient information: Fever in children (Beyond the Basics). www.uptodate.com©2014 UpToDate®. 3)Kara A, Periyodik Ateş Sendromları. Turkiye Klinikleri J Pediatr Sci. 2011
  3. 7(4). 4)Feder HM Jr, Periodic fever, aphthous stomatitis, pharyngitis, adenitis: a clinical review of a new syndrome. Curr Opin Pediatr. 2000
  4. John CC, Gilsdorf JR, Recurrent fever in children. Pediatr Infect Dis J. 2002
  5. Periodic fever with aphthous stomatitis, pharyngitis and adenitis (PFAPA syndrome).www.uptodate.com©2014 UpToDate®. 7)Marshall GS, Edwards KM, Butler J, Lawton AR, Syndrome of periodic fever, pharyngitis, and aphthous stomatitis. J Pediatr. 1987
  6. Thomas KT, Feder HM Jr, Lawton AR, Edwards KM, Periodic fever syndrome in children. J Pediatr. 1999
  7. Gattorno M, Caorsi R, Meini A et al. Differentiating PFAPA syndrome from monogenic periodic fevers. Pediatrics. 2009
  8. Dagan E, Gershoni-Baruch R, Khatib I, Mori A, Brik R, MEFV, TNF1rA, CARD15 and NLRP3 mutation analysis in PFAPA. Rheumatol Int. 2010
  9. Stojanov S, Hoffmann F, Kery A et al. Cytokine profile in PFAPA syndrome suggests continuous inflammation and reduced anti inflammatory response. Eur Cytokine Netw. 2006
  10. Stojanov S, Lapidus S, Chitkara P, et al. Periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) is a disorder of innate immunity and Th1 activation responsive to IL-1 blockade. Proc Natl Acad Sci USA. 2011
  11. Brown KL, Wekell P, Osla V, et al. Profile of blood cells and inflammatory mediators in periodic fever, aphthous stomatitis, pharyngitis and adenitis (PFAPA) syndrome. BMC Pediatr. 2010
  12. Wright Dg, Dale DC, Fauci AS, Wolff SM, Human cyclic neutropenia: clinical review and long-term follow-up of patients. Medicine (Baltimore). 1981
  13. Dale DC, Hammond WP 4th, Cyclic neutropenia: a clinical review. Blood Rev. 1988
  14. Engervall P, Andersson B, Björkholm M, Clinical significance of serum cytokine patterns during start of fever in patients with neutropenia. Br J Haematol. 1995
  15. Horwitz M, Benson KF, Person RE, Aprikyan AG, Dale DC, Mutations in ELA2, encoding neutrophil elastase, define a 21-day biological clock in cyclic haematopoiesis. Nat Genet. 1999
  16. Long SS. Syndrome of Periodic fever, Aphthous