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Journals / Anadolu Üniversitesi Bilim ve Teknoloji Dergisi :A-Uygulamalı Bilimler ve Mühendislik / 2016 / Cilt: 17 - Sayı: 5

EFFECT OF SYNTHESIS PARAMETERS ON ISONIAZID (INH) RELEASE FROM SILICA NANOSPHERES

Levent DEĞİRMENCİ
Nagihan KARAKAYA
Pages
905–914
Publication Date
2022-10-11
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Results indicated lower amount of INH release when higher amount of TEOS was utilized in synthesis.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Silica nanospheres containing isoniazid (INH) was synthesized based on a modified Stober process.
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Key Findings & Data:Synthesis parameters such as type of alcohol used as oil phase, tetra ethyl ortho silicate (TEOS) and ammonia (NH3) amounts, surfactant use and mixing time were altered and their effect on the release of INH was investigated.
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Conclusion & Impact:Results indicated lower amount of INH release when higher amount of TEOS was utilized in synthesis.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Silica nanospheres containing isoniazid (INH) was synthesized based on a modified Stober process. Synthesis parameters such as type of alcohol used as oil phase, tetra ethyl ortho silicate (TEOS) and ammonia (NH3) amounts, surfactant use and mixing time were altered and their effect on the release of INH was investigated. Results indicated lower amount of INH release when higher amount of TEOS was utilized in synthesis. Time of highest INH release was higher in the case of higher TEOS amount. NH3 had also a decreasing effect on INH release which had been due to the changes in pore structure. Scanning electron microscope (SEM) results clearly showed the necessity of surfactant use with smooth surfaces obtained with the samples where surfactant was utilized. Finally, mixing time was found to have a decreasing effect on the time of highest INH release and the amount of INH released from the spheres was also higher in the case of higher mixing time.

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Cite This Article

DEĞİRMENCİ, L., KARAKAYA, N. (2022). EFFECT OF SYNTHESIS PARAMETERS ON ISONIAZID (INH) RELEASE FROM SILICA NANOSPHERES. Anadolu Üniversitesi Bilim ve Teknoloji Dergisi :A-Uygulamalı Bilimler ve Mühendislik, Cilt: 17 - Sayı: 5, 905–914. https://ajindex.com/articles/438322

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