SavedAdd your journal

Journals / Anadolu Kliniği Tıp Bilimleri Dergisi / 2016 / Cilt: 21 - Sayı: 2

EEG Abnormalities Associated with the Use of Typical and Atypical Antipsychotics

Tipik ve Atipik Antipsikotik İlaç Kullanımına Bağlı EEG Anormallikleri

Handan ANKARALI
Süreyya EKEM
H. Tuğrul ATASOY
Nida Fatma TAŞCILAR
Esra ACIMAN DEMİREL
Banu BARUT ÖZEN
Pages
97–104
Publication Date
2022-10-11
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

EEG abnormalities other than epileptic activity were observed in 58.3% of the patients under typical antipsychotics (p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aim: Typical antipsychotics and clozapine could cause EEG abnormalities and risk of epileptic seizures.
📊
Key Findings & Data:Materials and Methods: EEG patterns were prospectively investigated in 102 patients with schizophrenia or schizoaffective disorders.
💡
Conclusion & Impact:EEG abnormalities other than epileptic activity were observed in 58.3% of the patients under typical antipsychotics (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: Typical antipsychotics and clozapine could cause EEG abnormalities and risk of epileptic seizures. Little is known about the effects of newer antipsychotics on EEG. The present study therefore examined the risk of EEG abnormalities associated with the use of atypical antipsychotics [clozapine, quetiapine, risperidone, olanzapine and new atypical antipsychotics (amisulpride, aripiprazole, paliperidone)] and of the typical antipsychotics (chlorpromazine, haloperidol, zuclopenthixol, pimozide). Materials and Methods: EEG patterns were prospectively investigated in 102 patients with schizophrenia or schizoaffective disorders. While 82 out of the 102 patients were under atypical [clozapine (n=16), risperidone (n=20), quetiapine (n=10), olanzapine (n=14), and new atypical antipsychotics (n=10)] and typical [haloperidol (n=5), chlorpromazine (n=2), zuclopenthixol (n=3), pimozide (n=2)] antipsychotic treatment, 20 of them were not under any treatment. These three groups were compared with a sex- and aged- matched control group of healthy volunteers (n=29). Results: No statistically significant difference regarding demographic characteristics was found between the groups. Both the patients who were not on any medication and the healthy volunteers had normal EEG's. Epileptic activity was observed in 31.3% of the patients under clozapine treatment (p0.05). EEG abnormalities other than epileptic activity were observed in 58.3% of the patients under typical antipsychotics (p

Özet

Amaç: Tipik antipsikotikler ve klozapin EEG anormalliklerine ve epileptik nöbetlere neden olabilir. Yeni kuşak antipsikotiklerin EEG üzerindeki etkileri çok fazla bilinmemektedir. Yapılan bu çalışmada klozapin, ketiapin, risperidon ve olanzapin gibi atipik antipsikotikler, amisülpirid, aripiprazol, paliperidon gibi yeni diğer atipik antipsikotikler ve klorpromazin, haloperidol, zuklopentiksol, pimozid gibi tipik antipsikotiklerin EEG anormallikleri üzerine etkileri araştırılmıştır. Gereç ve Yöntemler: Şizofreni veya şizoaffektif bozukluk tanılı 102 hasta prospektif olarak değerlendirilerek EEG'leri çekildi. Bunların 82'si atipik [klozapin (n:16), risperidon (n:20), ketiapin (n:10), olanzapin (n:14), diğer yeni atipik antipsikotikler (n:10)] ve tipik [haloperidol (n:5), klorpromazin (n:2), zuklopentiksol (n:3), pimozid (n:2)] antipsikotik kullanıyordu, 20'si ise ilaç kullanmıyordu. Bu üç alt grup; cinsiyet ve yaş uyumlu sağlıklı kontrol grubunun (n=29) EEG'leri ile karşılaştırıldı. Bulgular: Gruplar arasında demografik özellikler bakımından istatiksel olarak anlamlı fark saptanmadı. Hem ilaç kullanmayan hastaların hem de sağlıklı kontrollerin EEG'leri normaldi. Klozapin kullanan hastaların % 31,3'ünde (p0,05) epileptik aktivite gözlendi. Epileptik aktivite dışındaki EEG anormallikleri tipik antipsikotik kullananların %58,3'ünde (p

🔖

Cite This Article

ANKARALI, H., EKEM, S., ATASOY, H. T., TAŞCILAR, N. F., DEMİREL, E. A., ÖZEN, B. B. (2022). EEG Abnormalities Associated with the Use of Typical and Atypical Antipsychotics. Anadolu Kliniği Tıp Bilimleri Dergisi, Cilt: 21 - Sayı: 2, 97–104. https://ajindex.com/articles/437771

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (8)

  1. Centorrino F, Price BH, Tuttle M, Bahk WM, Hennen J, Albert MJ, et al. EEG abnormalities during treatment with typical and atypical antipsychotics. Am J Psychi- atry. 2002;159(1):109-15.
  2. Roubicek J, Major I. EEG profile and behavioral changes after a single dose of clozapine in normals and schizoph- renics. Biol Psychiatry. 1977;12(5):613-33.
  3. Moore NC, Tucker KA, Brin FB, Merai P, Shillcut SD, Coburn KL. Positive symptoms of schizophrenia: Res- ponse to haloperidol and remoxipride is associated with increased alpha EEG activity. Hum Psychopharmacol. 1999;12(1):75-80.
  4. Stevens JR, Bigelow L, Denney D, Lipkin J, Livermore AH, Rauscher F, et al. Telemetered EEG-EOG during psychotic behaviors of schizophrenia. Arch Gen Psychi- atry. 1979;36(3):251-62. Bridgers SL. Epileptiform abnormalities discovered on electroencephalographic screening of psychiatric inpati- ents. Arch Neurol. 1987;44(3):312-6.
  5. Silvestri RC, Bromfield EB, Khoshbin S. Clozapi- ne-induced seizures and EEG abnormalities in am- bulatory psychiatric patients. Ann Pharmacother. 1998;32(11):1147-51.
  6. Devinsky O, Honigfeld G, Patin J. Clozapine-related sei- zures. Neurology 1991;41(3):369-71. Baldessarini RJ. Drugs and the treatment of psychiatric disorders: depression and anxiety disorders. In: Hard- man JG, Limbird LE, Gilman AG (ed.), Goodman and Gilman's The Pharmacological Basis of Therapeutics, 10. ed. New York: McGraw-Hill; 2001:447-83. Amerikan Psikiyatri Birliği. Psikiyatride Hastalıkla- rın Tanımlanması ve Sınıflandırılması El Kitabı, 4. ed. (DSM-IV TR), (çev. Ertuğrul Köroğlu). Ankara: Hekim- ler Yayın Birliği; 2001:137-42. American Electroencephalographic Society. Guideline seven: a proposal for standard montages to be used in clinical EEG. J Clin neurophsiol. 1994;11(1):30-6. Small JG. Psychiatric disorders and EEG. In: Nieder- meyer E, DaSilva FL (ed.), Electroencephalography: Basic Principles, Clinical Applications, and Related Fi- elds, 5. ed. Baltimore: Lippincott Williams & Wilkins; 1999:639-61. Aminoff MJ. Electroencephalography: general principles and clinical applications. In: Aminoff MJ (ed.), Electro- diagnosis in Clinical Neurology, 3. ed. New York: Churc- hill-Livingstone; 1992:41-91.
  7. Saletu B, Anderer P, Kinsperger K, Grünberger J. To- pographic brain mapping of EEG in neuropsychop- harmacology. Part II: Clinical applications (pharma- co EEG imaging). Methods Find Exp Clin Pharma- col.1987;9(6):385-408.
  8. Westphal KP, Grozinger B, Diekmann V, Scherb W, Re- ess J, Leibing U, et