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Journals / Akademik Gıda / 2013 / Cilt: 11 - Sayı: 3-4

LC/MS Combined with High-Field Asymmetric Wave Ion Mobility Spectrometer (FAIMS) and its Applications on Food Analysis.

LC/MS ile Birleştirilmiş Yüksek Alan Asimetrik Dalga İyon Hareketliliği Spektrometresi (FAIMS) ve Gıda Analizlerinde Kullanımı

Gizem YILDIZ
Timur TONGUR
Bülent ŞIK
Taner ERKAYMAZ
Pages
96–100
Publication Date
2022-10-11
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

FAIMS combined with liquid chromatography-tandem mass spectrometry device provides separation of isomeric and isobaric analytes, reduces chemical noise, eliminates matrix interferences and improves signal-to-noise (S/N) ratio by selective ion transmission

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Ion mobility spectrometry (IMS) is an ion separation technique used to separate ionized molecules in the gas phase based on their mobility in a carrier gas.
📊
Key Findings & Data:IMS significantly improves the identification capabilities of mass spectrometric analysis methods.
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Conclusion & Impact:FAIMS combined with liquid chromatography-tandem mass spectrometry device provides separation of isomeric and isobaric analytes, reduces chemical noise, eliminates matrix interferences and improves signal-to-noise (S/N) ratio by selective ion transmission
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Ion mobility spectrometry (IMS) is an ion separation technique used to separate ionized molecules in the gas phase based on their mobility in a carrier gas. IMS significantly improves the identification capabilities of mass spectrometric analysis methods. High-Field Asymmetric Waveform Ion Mobility Spectrometry (FAIMS) is a new variation of ion mobility spectrometry. It is used under atmospheric pressure conditions and room temperature. The most important feature of the ion-mobility spectrometry method is the capability for gas-phase ion separation prior to mass spectrometry analysis. It is located between the ion source and the mass spectrometer. FAIMS when combined with mass spectrometry offers value-added data not possible from mass spectra alone. FAIMS combined with liquid chromatography-tandem mass spectrometry device provides separation of isomeric and isobaric analytes, reduces chemical noise, eliminates matrix interferences and improves signal-to-noise (S/N) ratio by selective ion transmission

Özet

İyon hareketliliği spektrometresi (IMS), bir taşıyıcı gaz içinde hareket eden iyonların ayırımını sağlayan bir iyon ayırma tekniğidir. IMS tekniği kütle spektrometresi ile yapılan analizlerin belirleme yeteneğini önemli ölçüde geliştirmektedir. Yüksek Alan Asimetrik Dalga İyon Hareketliliği Spektrometresi (FAIMS) yeni bir iyon hareketliliği spektrometresi tekniğidir. FAIMS atmosferik basınç koşullarında ve oda sıcaklığında kullanılmaktadır. Bu tekniğin en önemli özelliği kütle spektrometresi ile yapılacak analizden önce gaz fazında iyonların ayırımının sağlanmasıdır. Cihaz iyon kaynağı ile kütle spektrometresi arasına yerleştirilmektedir. Kütle spektrometresi cihazlarının FAIMS ile birleştirilmesi bazı ek avantajlar sağlamaktadır. Sıvı kromatografisi-tandem kütle spektrometresi (LC-MSMS) ile birleştirilmiş FAIMS cihazı, izomerik ve izobarik analitlerin ayrımını sağlamakta, kimyasal gürültüyü azaltmakta, matriks etkisini gidermekte ve sinyal/gürültü (S/N) oranını artırmaktadır

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Cite This Article

YILDIZ, G., TONGUR, T., ŞIK, B., ERKAYMAZ, T. (2022). LC/MS Combined with High-Field Asymmetric Wave Ion Mobility Spectrometer (FAIMS) and its Applications on Food Analysis.. Akademik Gıda, Cilt: 11 - Sayı: 3-4, 96–100. https://ajindex.com/articles/432841

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