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Journals / Afyon Kocatepe Üniversitesi Fen ve Mühendislik Bilimleri Dergisi / 2022 / Cilt: 22 - Sayı: 2

In vitro Antioxidant and Antimicrobial Activities of Some Novel 3-Alkyl-4-[3-methoxy-4-(p-nitrobenzoxy)-benzylideneamino]-4,5-dihydro-1H-1,2,4-triazol-5-ones

Bazı Yeni 3-Alkil-4-[3-metoksi-4-(p-nitrobenzoksi)-benzilidenamino]-4,5-dihidro-1H-1,2,4-triazol-5-on Bileşiklerinin in vitro Antioksidan ve Antimikrobiyal Özellikleri

Haydar YÜKSEK
Sevda MANAP
Zeynep EKİNCİ
Elif SEL
Pages
275–281
Publication Date
2022-10-12
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Furthermore, newly synthesized compounds antioxidant capacities were performed by three different methods.

📌 3 Key Takeaways

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Objective & Hypothesis:In this study, nine novel 3-alkyl-4-[3-methoxy-4-(p-nitrobenzoxy)-benzylideneamino]-4,5-dihydro-1H-1,2,4-triazol-5-ones (3) were synthesized from the reactions of 3-alkyl-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones (1) with 3-methoxy-4-(p-nitrobenzoxy)-benzaldehyde (2), which was synthesized by the reaction of 3-methoxy-4-hydroxybenzaldehyde with p-nitrobenzoyl chloride by using triethylamine.The structures of novel compounds were established from IR, 1H NMR and 13C NMR spectral data.
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Key Findings & Data:In addition, in vitro antibacterial capacities of the new compounds were determined against six bacteria by mains of agar well diffusion method.
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Conclusion & Impact:Furthermore, newly synthesized compounds antioxidant capacities were performed by three different methods.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

In this study, nine novel 3-alkyl-4-[3-methoxy-4-(p-nitrobenzoxy)-benzylideneamino]-4,5-dihydro-1H-1,2,4-triazol-5-ones (3) were synthesized from the reactions of 3-alkyl-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones (1) with 3-methoxy-4-(p-nitrobenzoxy)-benzaldehyde (2), which was synthesized by the reaction of 3-methoxy-4-hydroxybenzaldehyde with p-nitrobenzoyl chloride by using triethylamine.The structures of novel compounds were established from IR, 1H NMR and 13C NMR spectral data. In addition, in vitro antibacterial capacities of the new compounds were determined against six bacteria by mains of agar well diffusion method. Furthermore, newly synthesized compounds antioxidant capacities were performed by three different methods.

Özet

Bu çalışmada, dokuz yeni 3-alkil-4-[3-metoksi-4-(p-nitrobenzoksi)-benzilidenamino]-4,5-dihidro-1H-1,2,4-triazol-5-on (3) bileşiği 3-alkil-4-amino-4,5-dihidro-1H-1,2,4-triazol-5-on (1) bileşiklerinin 3-metoksi-4-hidroksibenzaldehidin trietilaminli ortamda p-nitrobenzoil klorür ile reaksiyonundan elde edilen 3-metoksi-4-(p-nitrobenzoksi)-benzaldehid (2) ile reaksiyonundan sentezlenmiştir. Sentezlenen yeni bileşikler IR, 1H NMR ve 13C NMR spektrum verileri kullanılarak karakterize edilmiştir. Çalışmada, ayrıca, yeni bileşiklerin in vitro antibakteriyal etkinlikleri altı bakteriye karşı agar kuyucuk yöntemi ile belirlenmiştir. İn vitro ortamda sentezlenen yeni bileşiklerin antioksidan aktiviteleri üç farklı yöntemle tayin edilmiştir.

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Cite This Article

YÜKSEK, H., MANAP, S., EKİNCİ, Z., SEL, E. (2022). In vitro Antioxidant and Antimicrobial Activities of Some Novel 3-Alkyl-4-[3-methoxy-4-(p-nitrobenzoxy)-benzylideneamino]-4,5-dihydro-1H-1,2,4-triazol-5-ones. Afyon Kocatepe Üniversitesi Fen ve Mühendislik Bilimleri Dergisi, Cilt: 22 - Sayı: 2, 275–281. https://ajindex.com/articles/429564

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