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Journals / Adıyaman Üniversitesi Fen Bilimleri Dergisi / 2022 / Cilt: 12 - Sayı: 1

Microbiological Investigation of the Effects of Olanzapine with Thymoquinone on the Intestine

Olanzapin ile Timokinon'un Bağırsak Üzerindeki Etkilerinin Mikrobiyolojik Olarak Araştırılması

Deniz TAŞTEMİR KORKMAZ
Sebile AZIRAK
Mehmet Kaya ÖZER
Ayşe Nilay GÜVENÇ
Nevin KOCAMAN
Sedat BİLGİÇ
Pages
106–119
Publication Date
2022-10-12
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In conclusion, with this study, it was determined that the treatment of TQ has a protective property against the side effects of OL.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:The aim of our study is to examine the effect of thymoquinone (TQ) in obese rats induced with the antipsychotic drug olanzapine (OL).
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Key Findings & Data:Thirty-five female Spraque-Dawley rats were divided into five groups (n = 7): Control, OL (2 mg / kg OL daily), OL + TQ1 (2 mg / kg OL + 20 mg / kg TQ), OL + TQ2 (2 mg / kg OL + 40 mg / kg TQ) and the OL + TQ3 group (2 mg / kg OL + 80 mg / kg TQ).
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Conclusion & Impact:In conclusion, with this study, it was determined that the treatment of TQ has a protective property against the side effects of OL.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

The aim of our study is to examine the effect of thymoquinone (TQ) in obese rats induced with the antipsychotic drug olanzapine (OL). Thirty-five female Spraque-Dawley rats were divided into five groups (n = 7): Control, OL (2 mg / kg OL daily), OL + TQ1 (2 mg / kg OL + 20 mg / kg TQ), OL + TQ2 (2 mg / kg OL + 40 mg / kg TQ) and the OL + TQ3 group (2 mg / kg OL + 80 mg / kg TQ). On the 15th day of treatment, intestinal tissue was removed for analysis. It has been found that TQ treatment affects the levels of Firmicutes and Bacteroides at varying rates in the intestinal flora in OL + TQ1, OL + TQ2, and OL + TQ3 groups, and also has a significant role in the apoptotic effect of TQ. In conclusion, with this study, it was determined that the treatment of TQ has a protective property against the side effects of OL. TQ can be an effective treatment method to increase therapeutic effectiveness.

Özet

Çalışmamızın amacı, bir antipsikotik ilaç olanzapin (OL) ile indüklenen obez sıçanlarda timokinonun (TQ) etkisini incelemektir. Otuz beş dişi Spraque-Dawley sıçanı beş gruba ayrıldı (n = 7): Kontrol, OL (günlük 2 mg / kg OL), OL + TQ1 (2 mg / kg OL + 20 mg / kg TQ), OL + TQ2 (2 mg/kg OL + 40 mg/kg TQ) ve OL + TQ3 grubu (2 mg/kg OL + 80 mg/kg TQ). Tedavinin 15. gününde, analiz için bağırsak dokusu çıkarıldı. TQ tedavisinin, OL+TQ1, OL+TQ2 ve OL+TQ3 gruplarında bağırsak florasındaki Firmicutes ve Bacteroides düzeylerini değişen oranlarda etkilediği ve ayrıca TQ'nun apoptotik etkisinde önemli rolü olduğu tespit edilmiştir. Sonuç olarak, bu çalışma ile TQ tedavisinin OL'nin yan etkilerine karşı koruyucu özelliği olduğu belirlendi. TQ, terapötik etkinliği artırmak için etkili bir tedavi yöntemi olabilir.

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Cite This Article

KORKMAZ, D. T., AZIRAK, S., ÖZER, M. K., GÜVENÇ, A. N., KOCAMAN, N., BİLGİÇ, S. (2022). Microbiological Investigation of the Effects of Olanzapine with Thymoquinone on the Intestine. Adıyaman Üniversitesi Fen Bilimleri Dergisi, Cilt: 12 - Sayı: 1, 106–119. https://ajindex.com/articles/428388

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