AI Summary & Key Takeaways
AI InsightWhen prostate cancer sub-groups were investigated, totaland native thiol levels were noted to be higher in patients with a Gleason score of 7,8, and 9 than in those with a Gleason score of 6; however, no statistically significantdifference was observed (p> 0.05).Conclusions: Thiol levels were higher in prostate cancer group than in benign disease (BPH and chronic prostatitis) groups; these levels were also higher in groupwith high Gleason scores (Gleason 7, 8, or 9) than in group with a low Gleason score(Gleason 6); however, these differences were not statistically significant.
📌 3 Key Takeaways
Abstract
Aim: We aimed to investigate thiol/disulphide homeostasis as an additional serummarker to prostate specific antigen (PSA) in the diagnosis of prostate cancer.Patients and Methods: Prospective study was conducted among 174 patients withPSA levels of 2.5–20 ng/mL without suspicion of malignancy in rectal examinationand who underwent prostate needle biopsy. A total of 75 patients were included in ourstudy after exclusion criteria. Serum PSA, thiol, and disulphide levels of the patientswere recorded prior to biopsy. In this study, 25 patients with pathology results indicating prostate cancer, 25 randomly selected patients with pathology results indicatingchronic prostatitis, and 25 randomly selected patients with pathology results indicating benign prostate hyperplasia (BPH) were included.Results: Total and native thiol levels were higher in prostate cancer group than inBPH and chronic prostatitis groups; however, no statistically significant differencewas observed (p> 0.05). When prostate cancer sub-groups were investigated, totaland native thiol levels were noted to be higher in patients with a Gleason score of 7,8, and 9 than in those with a Gleason score of 6; however, no statistically significantdifference was observed (p> 0.05).Conclusions: Thiol levels were higher in prostate cancer group than in benign disease (BPH and chronic prostatitis) groups; these levels were also higher in groupwith high Gleason scores (Gleason 7, 8, or 9) than in group with a low Gleason score(Gleason 6); however, these differences were not statistically significant.
Özet
Amaç: Bu çalışmada, prostat kanseri tanısında thiol/disülfid dengesinin prostat spesifik antijene (PSA) ek bir serum markırı olarak değerlendirmeyi amaçladık. Hastalar ve Yöntemler: Prospektif çalışmamız PSA düzeyi 2.5-20 ng / mL olan, rektal muayenede malignite şüphesi olmayan ve prostat iğnesi biyopsisi yapılan toplam 174 hasta üzerinde yapıldı. Dışlama kriterleri sonrası çalışmamıza toplam 75 hasta dahil edildi. Biyopsi öncesi hastaların serum PSA, thiol ve disülfid düzeyleri kaydedildi. Çalışmamıza patoloji sonucu prostat kanseri olan 25 hasta, patoloji sonucu kronik prostatit olan 25 hasta ve patoloji sonucu benign prostat hiperplazisi (BPH) olan 25 hasta dahil edildi. Bulgular: Prostat kanseri grubunda total ve native thiol seviyeleri BPH ve kronik prostatit gruplarından daha yüksekti; ancak, istatistiksel anlamlı bir farklılık gözlenmedi (p> 0.05). Prostat kanseri alt grupları incelendiğinde, total ve native thiol seviyelerinin Gleason skoru 7, 8 ve 9 olan hastalarda, Gleason skoru 6 olanlara göre daha yüksek olduğu saptandı; ancak, istatistiksel anlamlı bir fark gözlenmedi (p> 0.05). Sonuç: Thiol seviyeleri prostat kanseri grubunda, benign hastalık (BPH ve kronik prostatit) gruplarından daha yüksekti; bu seviyeler aynı zamanda Gleason skoru yüksek olan grupta (Gleason 7, 8 veya 9), Gleason skoru düşük olan (Gleason 6) gruba göre daha yüksekti; ancak, bu farklılıklar istatistiksel olarak anlamlı değildi.