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Journals / Balkan Medical Journal / 2018 / Cilt: 35 - Sayı: 4

The Role of Follicular Fluid Thiol/Disulphide Homeostasis in Polycystic Ovary Syndrome

Özcan EREL
Esra Nur TOLA
Hilmi Baha ORAL
Abdülkadir TURGUT
Merve ERGİN
Nadiye KÖROĞLU
Pages
306–310
Publication Date
2022-10-11
DOI
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⚡ TL;DR(Too Long; Didn't Read)

Thiol/disulphide homeostasis was analyzedvia a novel spectrophotometric method.Results: Follicular native thiol levels, as well as the native thiol/total thiol ratio, were lower in the polycystic ovary syndrome groupthan in the non-polycystic ovary syndrome group (p=0.041 andp

📌 3 Key Takeaways

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Objective & Hypothesis:Background: Oxidative stress has been proposed as a potentialtrigger in the etiopathogenesis of polycystic ovary syndromerelatedinfertility.
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Key Findings & Data:The study procedureswere approved by the local ethics committee.Study Design: Cross-sectional study.Methods: Follicular fluid from 22 women with polycystic ovarysyndrome and 20 ovulatory controls undergoing in vitro fertilizationtreatment was sampled.
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Conclusion & Impact:Thiol/disulphide homeostasis was analyzedvia a novel spectrophotometric method.Results: Follicular native thiol levels, as well as the native thiol/total thiol ratio, were lower in the polycystic ovary syndrome groupthan in the non-polycystic ovary syndrome group (p=0.041 andp
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Background: Oxidative stress has been proposed as a potentialtrigger in the etiopathogenesis of polycystic ovary syndromerelatedinfertility. Thiol/disulphide homeostasis, a recently identifiedoxidative stress marker, is one of the antioxidant mechanism inhumans with critical roles in folliculogenesis and ovulation.Aims: To investigate follicular fluid thiol/disulphide homeostasis inthe etiopathogenesis of polycystic ovary syndrome and to determine itsassociation with in vitro fertilization outcome. The study procedureswere approved by the local ethics committee.Study Design: Cross-sectional study.Methods: Follicular fluid from 22 women with polycystic ovarysyndrome and 20 ovulatory controls undergoing in vitro fertilizationtreatment was sampled. Thiol/disulphide homeostasis was analyzedvia a novel spectrophotometric method.Results: Follicular native thiol levels, as well as the native thiol/total thiol ratio, were lower in the polycystic ovary syndrome groupthan in the non-polycystic ovary syndrome group (p=0.041 andp

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Cite This Article

EREL, Ö., TOLA, E. N., ORAL, H. B., TURGUT, A., ERGİN, M., KÖROĞLU, N. (2022). The Role of Follicular Fluid Thiol/Disulphide Homeostasis in Polycystic Ovary Syndrome. Balkan Medical Journal, Cilt: 35 - Sayı: 4, 306–310. https://ajindex.com/articles/461069

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