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Journals / Molecular Imaging and Radionuclide Therapy / 2022 / Cilt: 31 - Sayı: 2

Elevated Angiogenic Factor Levels After Transarterial Radioembolization for Colorectal Cancer Liver Metastases May Predict a Poor Prognosis

Yüksek Anjiyojenik Faktör Seviyeleri Kolorektal Kanser Karaciğer Metastazları İçin Transarteriyel Radyoembolizasyon Sonrası Kötü Prognozu Öngörebilir

Atilla Halil Elhan
Mustafa Durmaz
Sadık Bilgiç
Mine Araz
Çiğdem Soydal
Elgin Özkan
Nuriye Özlem Küçük
Berrin İmge Ergüder
İbrahim Ethem Geçim
Pages
114–122
Publication Date
2022-09-03
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Results: Patients with elevated serum basic fibroblast growth factor and platelet-derived growth factor levels in the 1st week and vascular endothelial growth factor (VEGF) levels in the 6th week after TARE had significantly shorter median overall survival (OS) times.

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: To analyze the change in circulating angiogenic factor levels after transarterial radioembolization (TARE) for colorectal cancer liver metastases (CRCLMs) and its prognostic significance.
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Key Findings & Data:Methods: Blood samples immediately before TARE and on 1 day, 1 week and 6 weeks after were collected for angiogenic factor analysis in 23 patients.
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Conclusion & Impact:Results: Patients with elevated serum basic fibroblast growth factor and platelet-derived growth factor levels in the 1st week and vascular endothelial growth factor (VEGF) levels in the 6th week after TARE had significantly shorter median overall survival (OS) times.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: To analyze the change in circulating angiogenic factor levels after transarterial radioembolization (TARE) for colorectal cancer liver metastases (CRCLMs) and its prognostic significance. Methods: Blood samples immediately before TARE and on 1 day, 1 week and 6 weeks after were collected for angiogenic factor analysis in 23 patients. Results: Patients with elevated serum basic fibroblast growth factor and platelet-derived growth factor levels in the 1st week and vascular endothelial growth factor (VEGF) levels in the 6th week after TARE had significantly shorter median overall survival (OS) times. Conclusion: Some early increases in serum angiogenic factor levels and in serum VEGF in the 6th week after TARE for CRCLMs are related to short OS and progression-free survival

Özet

Amaç: Kolorektal kanser metastazları için transarteriyel radyoembolizasyon (TARE) sonrası dolaşımda anjiyojenik faktörlerin seviyelerindeki değişikliklerin analiz edilmesidir. Yöntem: Anjiyojenik faktör analizi için 23 hastada TARE’den hemen önce, 1. günde, 1. haftada ve 6 hafta sonra kan örnekleri toplandı. Bulgular: TARE sonrası 1. haftada bazik fibroblast büyüme faktörü ve platelet kaynaklı büyüme faktörü seviyelerinde ve 6. haftada vasküler endotelyal büyüme faktörü (VEGF) seviyelerinde artış olan hastalarda medyan genel sağkalım süreleri istatistiksel olarak daha kısaydı. Sonuç: Bazı anjiyojenik faktör seviyelerinde erken yükselişler ve kolorektal kanser metastazları için TARE sonrası 6. haftada serum VEGF seviyelerinde artış olması kısa genel sağkalım ve progresyonsuz sağkalım ile ilişkilidir.

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Cite This Article

Elhan, A. H., Durmaz, M., Bilgiç, S., Araz, M., Soydal, Ç., Özkan, E., Küçük, N. Ö., Ergüder, B. İ., Geçim, İ. E. (2022). Elevated Angiogenic Factor Levels After Transarterial Radioembolization for Colorectal Cancer Liver Metastases May Predict a Poor Prognosis. Molecular Imaging and Radionuclide Therapy, Cilt: 31 - Sayı: 2, 114–122. https://ajindex.com/articles/425703

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