Journals / İstanbul Journal of Pharmacy / 2018 / Cilt: 48 - Sayı: 2

Triterpenoids from Scorzonera veratrifolia Fenzl

Pages
23–27
Publication Date
2018-08-31
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The presence of these compounds has been shown for the first time in S. veratrifolia. α-amyrinone, ß-amyrin, ß-amyrinone, ψ – taraxasterol and ψ – taraxasterol acetate are new for the genus Scorzonera.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:DOI: 10.5152/IstanbulJPharm.2018.410411The genus Scorzonera (Asteraceae) has several species which are used as a vegetable and in folk medicine all around the world.
📊
Key Findings & Data:Seventeen triterpenoids (ß-amyrin, ß-amyrin acetate, ß-amyrinone, germanicol, germanicol acetate, germanicone, α-amyrin, α-amyrin acetate, α-amyrinone, ψ – taraxasterol, ψ – taraxasterol acetate, taraxasterol, taraxasterol acetate, lupeol, lupeol acetate, lupenone, fern-7-en-3-one) and one sterol (ß-sitosterol) were determined.
💡
Conclusion & Impact:The presence of these compounds has been shown for the first time in S. veratrifolia. α-amyrinone, ß-amyrin, ß-amyrinone, ψ – taraxasterol and ψ – taraxasterol acetate are new for the genus Scorzonera.
🔬Design:Research Article
📍Scope:2018 Verileri
⚙️Variables:Scorzonera veratrifolia · triterpenoids · sterol

Abstract

DOI: 10.5152/IstanbulJPharm.2018.410411The genus Scorzonera (Asteraceae) has several species which are used as a vegetable and in folk medicine all around the world. A phytochemical study was carried out on petroleum ether fraction of methanol extract obtained from the roots of Scorzonera veratrifolia Fenzl (Bitlis / Turkey) to investigate the terpenoid composition of the plant. Column chromatography, preparative thin layer chromatography and gas chromatography (GC) were used for separation of the compounds. Their structures were determined by using GC-MS and NMR techniques. Seventeen triterpenoids (ß-amyrin, ß-amyrin acetate, ß-amyrinone, germanicol, germanicol acetate, germanicone, α-amyrin, α-amyrin acetate, α-amyrinone, ψ – taraxasterol, ψ – taraxasterol acetate, taraxasterol, taraxasterol acetate, lupeol, lupeol acetate, lupenone, fern-7-en-3-one) and one sterol (ß-sitosterol) were determined. The presence of these compounds has been shown for the first time in S. veratrifolia. α-amyrinone, ß-amyrin, ß-amyrinone, ψ – taraxasterol and ψ – taraxasterol acetate are new for the genus Scorzonera.

🔖

Cite This Article

Çetin, B., Şahin, H., Sarı, A. (2018). Triterpenoids from Scorzonera veratrifolia Fenzl. İstanbul Journal of Pharmacy, Cilt: 48 - Sayı: 2, 23–27. https://ajindex.com/articles/41770

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (13)

  1. Ahmad VU, Atta ur R (1994). Handbook of natural products data. Volume 2: pentacyclic triterpenoids. Elsevier Science, Amsterdam. Altınordu F, Martin E, Makbul S, Coşkunçelebi K, Gültepe M (2015). Cytogenetic studies on some Scorzonera L. s.l. (Asteraceae) taxa from Turkey. Turk J Bot 39: 429-438.
  2. Bahadır O, Çitoglu GS, Smejkal K, Dall'Acqua S, Özbek H, Cvacka J, Zemlicka M (2010). Analgesic compounds from Scorzonera latifolia (Fisch. and Mey.) DC. J Ethnopharmacol 131: 83-87.
  3. Baytop T (1999). Türkiye'de Bitkilerle Tedavi Geçmişte ve Bugün (Therapy with medicinal plants in Turkey). Nobel Tıp, İstanbul.
  4. Budzikiewicz H, Wilson JM, Djerassi C (1963). Mass Spectrometry in Structural and Stereochemical Problems. XXXII.1 Pentacyclic Triterpenes. J Am Chem Soc 85: 3688-3699.
  5. Chamberlain DF (1975). Scorzonera L. In: PH Davis (ed./eds) FLORA OF TURKEY and the East Aegean Islands, V, Edinburgh University Press, Edinburgh, 632-657.
  6. Coşkunçelebi K, Makbul S, Gültepe M, Okur S, Güzel ME (2015). A conspectus of Scorzonera s.l. in Turkey. Turk J Bot 39: 76-87.
  7. Dakeng S, Duangmano S, Jiratchariyakul W, U-Pratya Y, Bögler O, Patmasiriwat P (2012). Inhibition of Wnt signaling by cucurbitacin B in breast cancer cells: Reduction of Wnt associated proteins and reduced translocation of galectin-3-mediated β-catenin to the nucleus. J Cell Biochem 113: 49-60.
  8. Ding N, Yamashita U, Matsuoka H, Sugiura T, Tsukada J, Noguchi J, Yoshida Y (2011). Apoptosis induction through proteasome inhibitory activity of cucurbitacin D in human T‐cell leukemia. Cancer 117: 2735-2746.
  9. Dudhgaonkar S, Thyagarajan A, Sliva D (2009). Suppression of the inflammatory response by triterpenes isolated from the mushroom Ganoderma lucidum. Int J Immunopharmacol 9: 1272-1280.
  10. Ezzat SM, Abdallah HM, Fawzy GA, El-Maraghy SA (2012). Hepatoprotective constituents of Torilis radiata Moench (Apiaceae). Nat Prod Res 26: 282-285.
  11. Gao Y, Zhang R, Zhang J, Gao S, Gao W, Zhang H, Wang H, Han B (2011). Study of the Extraction Process and In Vivo Inhibitory Effect of Ganoderma Triterpenes in Oral Mucosa Cancer. Molecules 16: 5315. Gawrońska-Grzywacz M, Krzaczek T (2007). Identification and determination of triterpenoids in Hieracium pilosella L. J Sep Sci 30: 746-750.
  12. Granica S, Lohwasser U, Johrer K, Zidorn C (2015). Qualitative and Quantitative Analyses of Secondary Metabolites in Aerial and Subaerial of Scorzonera hispanica L. (Black Salsify). Food Chem 173: 321-331.
  13. Hooper SN, Chandler RF, Lewis E, Jamieson WD (1982). S