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Journals / İstanbul Journal of Pharmacy / 2018 / Cilt: 48 - Sayı: 3

Ceragenins exhibiting promising antimicrobial activity against various multidrug resistant Gram negative bacteria

Özlem OYARDI
Paul B. SAVAGE
Alper AKÇALI
Zayre ERTURAN
Çağla BOZKURT-GÜZEL
Pages
68–72
Publication Date
2018-12-01
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In conclusion, ceragenins appear to be a good candidate as antimicrobial therapy in the presence of multidrug (including colistin) resistant microorganisms.

📌 3 Key Takeaways

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Objective & Hypothesis:DOI: 10.26650/IstanbulJPharm.2018.400730Ceragenins are novel promising agents for the treatment of infections caused by multi-drug resistant microorganisms.
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Key Findings & Data:Therefore, this study aimed to investigate in vitro antimicrobial activities of ceragenins (Cationic Steroid Antibiotics) (CSA-8, CSA-13, CSA-142 and CSA-192) against multidrug resistant Gram negative isolates from Turkey.
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Conclusion & Impact:In conclusion, ceragenins appear to be a good candidate as antimicrobial therapy in the presence of multidrug (including colistin) resistant microorganisms.
🔬Design:Research Article
📍Scope:2018 Verileri
⚙️Variables:Ceragenins · colistin resistance · gram negative pathogens

Abstract

DOI: 10.26650/IstanbulJPharm.2018.400730Ceragenins are novel promising agents for the treatment of infections caused by multi-drug resistant microorganisms. Since colistin resistance has become a worldwide problem, the need for new treatment agents has been increasing steadily. Therefore, this study aimed to investigate in vitro antimicrobial activities of ceragenins (Cationic Steroid Antibiotics) (CSA-8, CSA-13, CSA-142 and CSA-192) against multidrug resistant Gram negative isolates from Turkey. Experiments were performed by using broth microdilution method against Klebsiella pneumoniae, Morganella morganii, Pseudomonas aeruginosa and Stenotrophomonas maltophilia isolates. All microorganisms except for three isolates were identified as multidrug resistant. Among tested ceragenins, CSA-13 showed the best results (MIC: 8-64 µg/ml). Nevertheless, the antimicrobial activity of CSA-8 was not significant. In conclusion, ceragenins appear to be a good candidate as antimicrobial therapy in the presence of multidrug (including colistin) resistant microorganisms.

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Cite This Article

OYARDI, Ö., SAVAGE, P. B., AKÇALI, A., ERTURAN, Z., BOZKURT-GÜZEL, Ç. (2018). Ceragenins exhibiting promising antimicrobial activity against various multidrug resistant Gram negative bacteria. İstanbul Journal of Pharmacy, Cilt: 48 - Sayı: 3, 68–72. https://ajindex.com/articles/41765

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