Journals / Türk Hijyen ve Deneysel Biyoloji Dergisi / 2018 / Cilt: 75 - Sayı: 1

Distribution of candida species isolated from nosocomial infections of Ankara Numune Training and Research Hospital (2010-2015)

Ankara Numune Eğitim ve Araştırma Hastanesi’nde hastane enfeksiyonu etkeni olarak izole edilen candida suşlarının dağılımı (2010-2015)

Pages
21–28
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Epidemiological studies should be performed at regular intervals in all hospitals in order to appropriate control of nosocomial Candida infections.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: In the recent years, the epidemiology of nosocomial Candida infections and antifungals used in the treatment have changed significantly.
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Key Findings & Data:Although Candida albicans is the most frequently identified species, but incidence of non-albicans Candida species are increased lately.
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Conclusion & Impact:Epidemiological studies should be performed at regular intervals in all hospitals in order to appropriate control of nosocomial Candida infections.
🔬Design:Research Article
📍Scope:2010 Verileri
⚙️Variables:Domain Parameters

Abstract

Objective: In the recent years, the epidemiology of nosocomial Candida infections and antifungals used in the treatment have changed significantly. Although Candida albicans is the most frequently identified species, but incidence of non-albicans Candida species are increased lately. In this study, it is aimed to contribute to the epidemiological database of our hospital and country by evaluating the distribution of Candida species isolated from nosocomial Candida infections. Methods: It was evaluated that agents isolated from 3840 nosocomial infections that detected in patients hospitalized in intensive care units and clinical departments of Ankara Research and Training Hospital during January 2010 and December 2015. Candida species isolated from various clinical specimens were evaluated by Infection Control Committee according to the “Centers for Disease Control and Prevention (CDC)” criteria. Distrubition of 350 Candida species isolated from nosocomial infections were investigated. Results: During the study period, the number of nosocomial infections determined among the patients hospitalized at the intensive care units and clinical departments of Ankara Research and Training Hospital were 2559 and 1281 respectively. The rate of Candida species detected from nosocomial infections in intensive care units and clinical departments were 11.2%, 3.7% respectively. The most common Candida species identified as an agent of nosocomial Candida infections was Candida albicans (39.7%). Among the non-albicans Candida group, C. parapsilosis (20.9%) was the most common agent followed by C. glabrata (17.4%) and C. tropicalis (15.1%). The most common nosocomial Candida infections were detected as Urinary tract infections. Conclusion: Epidemiology of nosocomial Candida infections can change to years and by hospital. Epidemiological studies should be performed at regular intervals in all hospitals in order to appropriate control of nosocomial Candida infections.

Özet

Amaç: Son yıllarda nozokomiyal Candidaenfeksiyonlarının epidemiyolojisinde ve tedavisindekullanılan antifungallerle ilgili önemli değişiklikler ortayaçıkmıştır. Nozokomiyal Candida enfeksiyonlarının en sıketkeni Candida albicans olmakla birlikte, son zamanlardaalbicans dışı Candida türlerinin de sıklığı artmaktadır.Bu çalışmada nozokomiyal Candida enfeksiyonlarındanizole edilen Candida türlerinin dağılımı değerlendirilerekhastanemiz ve ülkemiz epidemiyolojik verilerine katkısağlanması amaçlanmıştır.Yöntem: Çalışmada Ocak 2010-Aralık 2015 tarihleriarasında Ankara Numune Eğitim ve Araştırma Hastanesiyoğun bakım ve klinik sevislerinde yatarak tedavi görenhastalarda gelişen 3840 nozokomiyal enfeksiyondanizole edilen etkenler değerlendirilmiştir. Çeşitli klinikörneklerden izole edilen Candida suşları HastaneEnfeksiyon Kontrol Komitesi tarafından Hastalık Kontrolve Önleme Merkezi (CDC) kriterlerine göre nozokomiyalenfeksiyon etkeni olarak kabul edilmiştir. Nozokomiyalenfeksiyon etkeni olarak tespit edilen 350 Candidasuşunun dağılımı incelenmiştir.Bulgular: İzlenen dönem içinde Ankara NumuneEğitim ve Araştırma Hastanesi yoğun bakım ünitelerinde2559, klinik ünitelerinde 1281 nozokomiyal enfeksiyontespit edilmiştir.Nozokomiyal enfeksiyon etkenleri içindeCandida türleri, yoğun bakım ünitelerinde %11,2, klinikünitelerde %3,7 oranında olarak saptanmıştır. Candidaalbicans (%39,7), nozokomiyal kandida enfeksiyonlarınaneden olan türler arasında en sık görülen etken olaraktespit edilmiştir. Albicans dışı kandida türleri arasındaise en sık görülen etkenin C. parapsilosis (%20,9) olduğusaptanmış, bunu C. glabrata (%17,4) ve C. tropicalis(%15,1) izlemiştir. En sık karşılaşılan nozokomiyalkandida enfeksiyonu, üriner sistem enfeksiyonu olaraktespit edilmiştir.Sonuç: Nozokomiyal Candida enfeksiyonlarınınepidemiyolojisi yıllara göre ve merkezlere göredeğişebilmektedir. Nozokomiyal Candida enfeksiyonlarınınuygun yönetilebilmesi için hastanelerde düzenli aralıklarlaepidemiyolojik çalışmaların yapılması gereklidir.

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Cite This Article

HAZIROLAN, G. (2018). Distribution of candida species isolated from nosocomial infections of Ankara Numune Training and Research Hospital (2010-2015). Türk Hijyen ve Deneysel Biyoloji Dergisi, Cilt: 75 - Sayı: 1, 21–28. https://ajindex.com/articles/417076

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References (14)

  1. Eggimann P, Que YA, Revelly JP, Pagani JL. Preventing invasive candida infections. Where could we do better? J Hosp Infect, 2015; 89 (4): 302-8
  2. Kauffman CA. Fungal Infections. Proc Am Thorac Soc, 2006; 3 (1): 35-40
  3. Khan ZU, Chandy R, Metwali KE. Candida albicans strain carriage in patients and nursing staff of an intensive care unit: a study of morphotypes and resistotypes. Mycoses, 2003; 46 (11-12): 479-86
  4. Tiraboschi IN, Bennett JE, Kauffman CA, Rex JH, Girmenia C, Sobel JD et al. Deep Candida infections in theneutropenic and on-neutropenic host: an ISHAM symposium. Med Mycol, 2000; 38(1): 199- 204
  5. Brown GD, Denning DW, Gow NA, Levitz SM, Netea MGWhite TC. Hidden killers: human fungal infections. Science translational medicine, 2012; 4(165): 165rv13
  6. Vincent JL, Rello J, Marshall J, Silva E, Anzueto A, Martin CD, et al. International study of the prevalence and outcomes of infection in intensive care units. JAMA, 2009; 302 (23): 2323-29
  7. Pfaller MA, Castanheira M. Nosocomial Candidiasis: Antifungal Stewardship and the Importance of Rapid Diagnosis. Medical Mycology, 2016; 54(1): 1-22
  8. Horan TC, Andrus M, Dudeck MA. CDC/NHSN surveillance definition of healthcare-associated infection and criteria for specific types of infections in the acute care setting. Am J Infect Control, 2008; 36(5): 309-32
  9. Fridkin SK, Jarvis WR. Epidemiology of nosocomial fungal infections. Clin Microbiol Rev, 1996; 9(4): 499-511
  10. Horasan EŞ, Ersöz G, Göksu M, Otag F, Kurt AO, Karaçorlu S.ve ark. Increase in Candida parapsilosis fungemia in critical care units: a 6-years study. Mycopathologia, 2010; 170(4): 263-8
  11. Otağ F, Aslan G, Şen S, Özturhan H, Emekdaş G. 2003-2005 süresinde klinik örneklerden izole edilen maya türlerinin değerlendirilmesi. Infeks Derg, 2005; 19:435-43
  12. Pfaller MA, Castanheira M, Messer AS, Moet GJ, Jones RN. Variation in Candida spp. distribution and antifungal resistance rates among bloodstream infection isolates by patient age: report from the SENTRY Antimicrobial Surveillance Program (2008- 2009). Diagn Microbiol Infect Dis, 2010; 68(3): 278- 83
  13. Kibbler CC, Seaton S, Barnes RA, Gransden WR, Holliman RE, Johnson EM. et al. Management and outcome of bloodstream infections due to Candida species in England and Wales. J Hosp Infect, 2003; 54(1): 18-24
  14. Vincent JL, Bihari DJ, Suter PM, Bruining HA, White J, Nicolas-Chanoin MH, et al. The prevalence of nosocomial infection in intensive care units in Europe. Resu