Journals / Türkderm-Deri Hastalıkları ve Frengi Arşivi / 2018 / Cilt: 52 - Sayı: 3

Effect of psoriasis severity on inflammation parameters: Controlled study

Psoriazis şiddetinin enflamasyon parametreleri üzerine etkisi: Kontrollü çalışma

Pages
91–94
DOI
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⚡ TL;DR(Too Long; Didn't Read)

Conclusion: CRP value can be used as an objective parameter for evaluating chronic inflammation in psoriasis patients.

📌 3 Key Takeaways

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Objective & Hypothesis:Background and Design: Psoriasis is a complex and chronic disease that may be associated with systemic diseases.
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Key Findings & Data:In this study, our aim was to show the relationship of C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) values with disease severity.
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Conclusion & Impact:Conclusion: CRP value can be used as an objective parameter for evaluating chronic inflammation in psoriasis patients.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Background and Design: Psoriasis is a complex and chronic disease that may be associated with systemic diseases. In this study, our aim was to show the relationship of C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) values with disease severity. Additionally, the relationship between body mass index (BMI) values and inflammation markers was investigated. Materials and Methods: Sixty-two patients with chronic plaque psoriasis and 62 non-psoriasis patients were included in the study. Psoriasis severity was calculated using the psoriasis area severity index (PASI). The relationship of psoriasis severity with BMI, serum CRP and ESR values were investigated. In addition, psoriasis patient data were compared with control group data. Results: Of the 62 psoriasis patients included in the study, 31 (50%) were female and 31 (50%) were male. The ages of the patients ranged from 18 to 69 years and the mean age was 41.74±13.96 years. The mean PASI score was determined to be 15.86±8.95. CRP, ESR and BMI values were higher in psoriasis patients than in controls (p<0.05). In addition, CRP and BMI values were significantly increased as psoriasis severity increased (p<0.05). However, there was no relationship between ESR and psoriasis severity (p=0.82). Conclusion: CRP value can be used as an objective parameter for evaluating chronic inflammation in psoriasis patients.

Özet

Amaç: Psoriazis, sistemik hastalıklarla birliktelik gösterebilen kompleks kronik bir hastalıktır. Bu çalışmada enflamasyon belirteçleri olan C-reaktif protein (CRP) ve eritrosit sedimantasyon hızı (ESH) değerlerinin hastalık şiddeti ile ilişkisini göstermek amaçlandı. Ayrıca vücut kitle indeksi (VKİ) değerlerinin enflamasyon belirteçleri ile olan ilişkisi araştırıldı.Gereç ve Yöntem: Çalışmaya kronik plak psoriazisi olan 62 hasta ve psoriazis dışı neden ile başvuran 62 kontrol hastası dahil edildi. Psoriazis şiddeti psoriazis alan şiddet indeksi (PAŞİ) kullanılarak hesaplandı. Psoriazis şiddetinin VKİ, serum CRP ve ESH değerleri ile ilişkisi değerlendirildi. Ayrıca psoriazis hasta verileri kontrol grubu verileri ile karşılaştırıldı.Bulgular: Çalışmaya dahil edilen 62 hastanın 31’i (%50) kadın iken, 31’i (%50) erkekti. Hastaların yaşları 18-69 arasında olup, yaş ortalaması 41,74±13,96 olarak belirlendi. Ortalama PAŞİ skoru ise 15,86±8,95 olarak belirlendi. Psoriazis hastalarında, kontrol grubuna göre CRP, ESH ve VKİ değerleri istatistiksel olarak daha yüksek saptandı (p<0,05). Ayrıca CRP ve VKİ değerlerinin psoriazis şiddeti arttıkça anlamlı oranda arttığı gözlendi (p<0,05). Ancak ESH ile psoriazis şiddeti arasında bir ilişki saptanmadı (p=0,82).Sonuç: Psoriazis hastalarında CRP değeri kronik enflamasyonun değerlendirilmesinde objektif bir parametre olarak kullanılabilir.

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Cite This Article

GÖKALP, H. (2018). Effect of psoriasis severity on inflammation parameters: Controlled study. Türkderm-Deri Hastalıkları ve Frengi Arşivi, Cilt: 52 - Sayı: 3, 91–94. https://ajindex.com/articles/414082

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